skip to main content

New Chemicals and Routes for the Preparation of Gelatin/HA Composites using the Wet Precipitation Method

1Physical-Inorganic Chemistry Laboratory, Department of Chemistry, Mathematics and Natural Sciences Faculty, Universitas Padjadjaran, Indonesia

2Department of Physics, Mathematics and Natural Sciences Faculty, Institut Teknologi Bandung, Indonesia

3Chemistry Department, Faculty of Mathematics and Science, Universitas Padjadjaran, Indonesia

Received: 10 Sep 2019; Revised: 18 Feb 2020; Accepted: 27 Feb 2020; Published: 29 Feb 2020.
Open Access Copyright 2020 Jurnal Kimia Sains dan Aplikasi under

Citation Format:
Cover Image
Hydroxyapatite (HA) is a material that has many uses in a wide variety of applications such as bone repair, bone implants, and bone drug delivery systems. However, the main weakness of this material is its mechanical strength, which HA is not enough to be directly applied. Gelatin addition is used to improve the mechanical properties that can support material properties for the load-bearing application. This research aimed to obtain gelatin/HA composites with high mechanical strength. This goal is achieved by finding the optimum composite composition (addition of 20, 30, and 40% w/w gelatin), CaO precursors from chicken eggshells, and gradual composite preparation. The preparation of gelatin/HA composites was carried out using the wet precipitation method. The chemical bonding, the compressive strength of HA and gelatin/HA composites, and also morphologies were analyzed by Fourier Transform Infra-Red (FTIR), Universal Testing Machine, and Scanning Electron Microscopy (SEM) respectively. The FTIR spectra show there are chemical bonds between amide and carboxyl in gelatin and Ca2+ in HA. The best compressive strength obtained at the composition of 20% gelatin/HA composite is 99.3 MPa (meanwhile HA is 81.5 MPa). The addition of gelatin to HA increases the particle density; this contributes to the increase in mechanical strength.
Fulltext View|Download
Keywords: hydroxyapatite; gelatin; mechanical properties; compressive strength

Article Metrics:

  1. Mehdi Kazemzadeh Narbat, Fariba Orang, Mehran Solati Hashtjin and Azadeh Goudarzi, Fabrication of porous hydroxyapatite-gelatin composite scaffolds for bone tissue engineering, Iranian Biomedical Journal, 10, 4, (2006), 215-223
  2. Shao Ching Chao, Ming-Jia Wang, Nai-Su Pai and Shiow-Kang Yen, Preparation and characterization of gelatin–hydroxyapatite composite microspheres for hard tissue repair, Materials Science and Engineering: C, 57, (2015), 113-122
  3. V Rodríguez-Lugo, E Salinas-Rodríguez, RA Vázquez, K Alemán and AL Rivera, Hydroxyapatite synthesis from a starfish and β-tricalcium phosphate using a hydrothermal method, RSC advances, 7, 13, (2017), 7631-7639
  4. M. P. Ginebra, T. Traykova and J. A. Planell, Calcium phosphate cements as bone drug delivery systems: A review, Journal of Controlled Release, 113, 2, (2006), 102-110
  5. S. K. Yen and C. M. Lin, Cathodic reactions of electrolytic hydroxyapatite coating on pure titanium, Materials Chemistry and Physics, 77, 1, (2003), 70-76
  6. Wang Feng, Li Mu-sen, Lu Yu-peng and Qi Yong-xin, A simple sol–gel technique for preparing hydroxyapatite nanopowders, Materials Letters, 59, 8, (2005), 916-919
  7. I. Mobasherpour, M. Soulati Heshajin, A. Kazemzadeh and M. Zakeri, Synthesis of nanocrystalline hydroxyapatite by using precipitation method, Journal of Alloys and Compounds, 430, 1, (2007), 330-333
  8. Purnendu Parhi, A. Ramanan and Alok R. Ray, A convenient route for the synthesis of hydroxyapatite through a novel microwave-mediated metathesis reaction, Materials Letters, 58, 27, (2004), 3610-3612
  9. Zaw Linn Htun, Nurazreena Ahmad, Aye Aye Thant and Ahmad-Fauzi Mohd Noor, Characterization of CaO-ZrO2 Reinforced Hap Biocomposite for Strength and Toughness Improvement, Procedia Chemistry, 19, (2016), 510-516
  10. C. R. Gautam, Sunil Kumar, Vijay Kumar Mishra and Santoshkumar Biradar, Synthesis, structural and 3-D architecture of lanthanum oxide added hydroxyapatite composites for bone implant applications: Enhanced microstructural and mechanical properties, Ceramics International, 43, 16, (2017), 14114-14121
  11. Jayachandran Venkatesan and Se-Kwon Kim, Chitosan Composites for Bone Tissue Engineering—An Overview, Marine Drugs, 8, 8, (2010), 2252-2266
  12. Naznin Sultana, Masturah Mokhtar, Mohd Izzat Hassan, Rashid Mad Jin, Fatemeh Roozbahani and Tareef Hayat Khan, Chitosan-based nanocomposite scaffolds for tissue engineering applications, Materials and Manufacturing Processes, 30, 3, (2015), 273-278
  13. Shu-Hua Teng and Peng Wang, One-pot synthesis of HA-coated gelatin microspheres by an emulsion method, Materials Letters, 65, 9, (2011), 1348-1350
  14. Haile Abrham, Synthesis and characterization of zinc substituted Hydroxyapatite extracted from an egg shell by wet precipitation method, School of Mechanical, Chemical and Materials Engineering, Adama Science and Technology University,
  15. Cheng Xianmiao, Li Yubao, Zuo Yi, Zhang Li, Li Jidong and Wang Huanan, Properties and in vitro biological evaluation of nano-hydroxyapatite/chitosan membranes for bone guided regeneration, Materials Science and Engineering: C, 29, 1, (2009), 29-35
  16. Xuan Cai, Hua Tong, Xinyu Shen, Weixuan Chen, Juan Yan and Jiming Hu, Preparation and characterization of homogeneous chitosan–polylactic acid/ hydroxyapatite nanocomposite for bone tissue engineering and evaluation of its mechanical properties, Acta Biomaterialia, 5, 7, (2009), 2693-2703

Last update:

  1. Impact of Alkaline Immersion Time on Nano-Hydroxyapatite Synthesis from Broiler Eggshells with Electrochemical Method Using Constant Direct Current (CDC)

    Asep Muhamad Samsudin, Tutuk Djoko Kusworo, Hana Nikma Ulya, Muhammad Akhsanil Auladi. Jurnal Kimia Sains dan Aplikasi, 26 (11), 2023. doi: 10.14710/jksa.26.11.421-426
  2. The Effect of Temperature Synthesis on the Purity and Crystallinity of Hydroxyapatite

    Azhari Yusuf, Norman Maulana Muhammad, Atiek Rostika Noviyanti, Risdiana. Key Engineering Materials, 860 , 2020. doi: 10.4028/

Last update: 2024-04-23 01:54:06

  1. The Effect of Temperature Synthesis on the Purity and Crystallinity of Hydroxyapatite

    Azhari Yusuf, Norman Maulana Muhammad, Atiek Rostika Noviyanti, Risdiana. Key Engineering Materials, 860 , 2020. doi: 10.4028/