Chemistry Department, Faculty of Sciences and Mathematics, Diponegoro University, Jl. Prof. Soedarto, SH., Tembalang, Semarang, Indonesia
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@article{JKSA83639, author = {Tri Windarti and Ngadiwiyana Ngadiwiyana and Fadila Fibriani}, title = {The Release of Curcumin from β-TCP/SiO₂/Curcumin Composites in a Ringer’s Lactate Solution}, journal = {Jurnal Kimia Sains dan Aplikasi}, volume = {29}, number = {5}, year = {2026}, keywords = {Calcium phosphate cement; β-TCP; SiO₂; curcumin}, abstract = {Osteoporosis is characterized by bone deterioration caused by high levels of reactive oxygen species (ROS), which inhibit osteoblast activity and lead to a decrease in bone density. Adding curcumin, a natural antioxidant, to calcium phosphate cement (CPC) enhances its function beyond simply increasing bone density. In this study, CPC was prepared from a β-tricalcium phosphate (β-TCP, β-Ca 3 (PO 4 ) 2 ) composite with curcumin. To enhance the interaction between β- TCP and curcumin, silicon dioxide (SiO 2 ) was added. β-TCP was synthesized by the sol-gel method, with SiO 2 content ranging from 1.6 to 8.3%. CPC preparation was carried out using a 2.5% Na 2 HPO 4 solution. The release of curcumin in a Ringer’s lactate solution was studied in relation to the role of SiO 2 . The UV-Vis spectral intensity of the remaining Ringer’s lactate solution after soaking decreased as the SiO 2 content increased. Results from a five-day soaking period showed that β-TCP did not transform into hydroxyapatite, but rather experienced a decrease in crystallinity and average crystal size from 96.175% to 25.524% and from 58.335 nm to 39.474 nm, respectively. Therefore, it can be predicted that CPC can maintain the presence of curcumin in a physiological environment.}, issn = {2597-9914}, pages = {373--378} doi = {10.14710/jksa.29.5.373-378}, url = {https://ejournal.undip.ac.id/index.php/ksa/article/view/83639} }
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