DOI: https://doi.org/10.14710/reaktor.16.3.128--140

Kinetika Release Mikrokapsul Oleoresin Jahe Merah

*Jayanudin Jayanudin  -  Jurusan Teknik Kimia, Fakultas Teknik Universitas Sultan Ageng Tirtayasa, Indonesia
R Rochmadi  -  Jurusan Teknik Kimia, Fakultas Teknik Universitas Gajah Mada
Meri Yulvianti  -  Jurusan Teknik Kimia, Fakultas Teknik Universitas Sultan Ageng Tirtayasa
Ahmad Imanudin  -  Jurusan Teknik Kimia, Fakultas Teknik Universitas Sultan Ageng Tirtayasa
Tri Rina Sari  -  Jurusan Teknik Kimia, Fakultas Teknik Universitas Sultan Ageng Tirtayasa
Received: 14 Jul 2016; Published: 13 Feb 2017.
Open Access Copyright (c) 2017 REAKTOR

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Abstract

Abstract

 

RELEASE KINETICS OF RED GINGER OLEORESIN MICROCAPSULES. Red ginger oleoresin microcapsule is used to protect the active component of medicine against the negative effect of the environment, thus the microcapsule can be applied in the pharmaceutical industries. Kinetic release is used to determine the rate of red ginger oleoresin microcapsule release in human body system. The models used for this purpose are zero order, first order, Higuchi, and Korsmeyer-Peppas. These models were completed by using graphical method to get the determination coefficient (R2). The aims of this research are to determine the effect of Tripolyphosphate (TPP) concentration towards microcapsule release, to determine the red ginger oleoresin microcapsule kinetic release, and to characterize the morphology and particle sizes of red ginger oleoresin microcapsule using the Scanning Electron Microscopy (SEM). The encapsulation method was started by emulsifying process of chitosan-alginate, with various ratios of Chitosan-Alginate such as 1:2, 1:1, 2:1, and 20 gram red ginger oleoresin, and also the addition of TPP, with various concentrations for as much as 3%, 4 %, and 5%, as the crosslinking agent. The emulsion was forwarded to the spray dryer machine to produce the red ginger oleoresin microcapsule. Then, the microcapsule was treated with the mixture of KH2PO4 and NaOH (pH 6.8) for 1 hour, and sample was taken for every 10 minutes for the dissolution test. The result showed that the increase of TPP concentration will reduce the release velocity of the active compound. Kinetic model with the highest value of R2 was the Korsmeyer-Peppas model.

 

Keywords: alginate; encapsulation; release kinetics; chitosan red ginger oleoresin;

 

 

Abstrak

 

Mikrokapsul digunakan untuk melindungi oleoresin jahe merah yang sensitif terhadap pengaruh lingkungan, sehingga dapat diaplikasikan dalam bidang farmasi. Kinetika release digunakan untuk menentukan kecepatan release mikrokapsul oleoresin jahe merah, model yang digunakan adalah model order nol, order satu, model Higuchi, dan Model Korsmeyer-Peppas. Penyelesaian model-model ini menggunakan metode grafis dengan menentukan koefisien determinasi (R2). Tujuan penelitian ini adalah menentukan pengaruh konsentrasi sodium tripolifosfat (TPP) dan rasio berat antara kitosan dan alginate sebagai penyalut terhadap kinetika release dan karakterisasi morfologi mikrokapsul oleoresin jahe merah.  Metode enkapsulasi dimulai dengan pembentukan emulsi dari penyalut kitosan-alginat dengan rasio 1:2; 1:1; 2:1 dan 20 gram oleoresin jahe merah, penambahan TPP 3%, 4% dan 5% untuk cross-link. Emulsi dialirkan ke spray dryer untuk menghasilkan mikrokapsul oleoresin jahe merah. Uji disolusi menggunakan medium basa dengan mencampurkan KH2PO4 dan NaOH (pH 6,8) sampel diambil tiap 10 menit selama 1 jam. Hasil penelitian yang telah dilakukan didapat peningkatan konsentrasi TPP akan menurunkan kecepatan releasenya, model model kinetika dengan nilai R2 terbesar adalah model Korsmeyer-Peppas.

 

Kata kunci: alginat; enkapsulasi; kinetika release; kitosan; oleoresin jahe merah

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Keywords: Alginat, Enkapsulasi, Kinetika release, Kitosan, Oleoresin jahe merah

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  1. Ali, B.H., Blunden, G., Tanira, M.O., and Nemmar, A., (2008), Some Phytochemical, Pharmacological and Toxicological Properties of Ginger (Zingiber Officinale Roscoe): A Review of Recent Research, Food and Chemical Toxicology, 46 (2), pp. 409–420
  2. Arianto, A., Bangun, H., Harahap, U., and Ilyas, S., (2014), The Comparison of Swelling, Mucoadhesive, And Release of Ranitidine from Spherical Matrices of Alginate, Chitosan, Alginate-Chitosan, and Calcium Alginate-Chitosan, International Journal of PharmTech Research, 6(7), pp. 2054-2063
  3. Balasubramani, P., Viswanathan, R., and Vairamani, M., (2013), Response Surface Optimisation of Process Variables for Microencapsulation of Garlic (Allium sativum L.) Oleoresin by Spray Drying, Biosystem Engineering, 114(3), pp. 205-213
  4. Bellik, Y., (2014), Total Antioxidant Activity and Antimicrobial Potency of the Essential Oil and Oleoresin of Zingiber officinale Roscoe, Asian Pacific Journal of Tropical Disease, 4(1), pp. 40-44
  5. Bhattarai, S., Tran, V.H., and Duke, C.C., (2007), Stability of [6]-gingerol and [6]-shogaol in Simulated Gastric and Intestinal Fluids, Journal of Pharmaceutical and Biomedical Analysis, 45(4), pp. 648–653
  6. Caetano, L.A., Almeida, A.J., and Gonçalves, L.M.D. (2016), Effect of Experimental Parameters on Alginate/Chitosan Microparticles for BCG Encapsulation, Marine Drugs, 14(5), pp. 1-30
  7. Cheon, J.W., Shim, C.K., Chung, S.J., and Kim, DD. (2009), Effect of Tripolyphosphate (TPP) on the Controlled Release of Cyclosporin A from Chitosan-coated Lipid Microparticles, Journal of Korean Pharmaceutical Sciences, 39(1), pp. 59-63
  8. Chime Salome, A, Onunkwo, G.C., and Onyishi, I.I. (2013), Kinetics and Mechanisms of Drug Release from Swellable and Non Swellable Matrices: A Review, Research Journal of Pharmaceutical, Biological and Chemical Sciences, 4(2), pp. 97-103
  9. Corbridge, D.E.C. and Lowe, E.J. (1954), The Infra-red Spectra of Some Inorganic Phosphorus Compounds, Journal of chemical sciences (Bangalore), pp. 493-502, https://doi.org/ 10.1039/JR9540000493
  10. Costa, P. and Lobo, J.M.S., (2001), Modeling and Comparison of Dissolution Profiles, European Journal of Pharmaceutical Sciences, 13(2), pp. 123–133
  11. Daemi, H. and Barikani, M. (2012), Synthesis and Characterization of Calcium Alginate Nanoparticles, Sodium Homopolymannuronate Salt and Its Calcium Nanoparticles, Scientia Iranica, 19(6), pp. 2023-2028
  12. Das, R.K., Kasoju, N., and Bora, U., (2010), Encapsulation of Curcumin in Alginate-Chitosan-Pluronic Composite Nanoparticles for Delivery to Cancer Cells, Nanomedicine: Nanotechnology, Biology, and Medicine, 6(1), pp. 153–160
  13. Dash, S., Murthy, P.N., Nath, L., and Chowdhury, P. (2010), Kinetic Modeling on Drug Release from Controlled Drug Delivery Systems, Acta Poloniae Pharmaceutica-Drug Research, 67(3), pp. 217- 223
  14. de Vos, P., Faas, M.M., Spasojevic, M., and Sikkema, J. (2010), Encapsulation for Preservation of Functionality and Targeted Delivery of Bioactive Food Components, International Dairy Journal, 20(4), pp. 292-302
  15. Desai, K.G.H. and Park H.J. (2005), Recent Developments in Microencapsulation of Food Ingredients, Drying Technology, 23(7), pp. 1361-1394
  16. Donati, I. and Paoletti, S., (2009), Material Properties of Alginate. In: Alginates: Biology and Applications, editors B.H.A. Rehm, Volume 13, Springer-Verlag Berlin Heidelberg, pp. 1-55
  17. Domszy, J.G. and Roberts, A.F., (1985), Evalution of Infrared Spectroscopic Technique for Analysing Chitosan, Macromolecular Chemistry and Physics, 186(8), pp. 1671-1677
  18. Dugasani, S., Pichikac, M.R., Nadarajah, V.D., Balijepalli, M.K.., Tandra, S., and Korlakunta, J.N. (2010), Comparative Antioxidant and Anti-Inflammatory Effects of [6]-gingerol, [8]-gingerol, [10]-gingerol and [6]-shogaol, Journal of Ethnopharmacology, 127(2), pp. 515–520
  19. Eze, J.I. and Agbo, K.E., (2011), Comparative Studies of Sun and Solar Drying of Peeled and Unpeeled Ginger, American Journal of Scientific and Industrial Research, 2(2), pp. 136-143
  20. Fang, Z. and Bhandari, B. (2010), Encapsulation of Polyphenols – A Review, Trends in Food Science & Technology, 21(10), pp. 510–523
  21. Friedli, A.C. and Schlager, I.R. (2005), Demonstratin Encapsulation and Release: A New Take on Alginate Complexation and the Nylon Rope Trick, Journal of Chemical Education, 82(7), pp. 1017-1020
  22. Garg, A., Kumar, A., and Kohli, K., (2013), Dilution Phenomenon in Mixed Surfactant based Self Micro Emulsifying Formulations of Ginger Oleoresin: Ex Vivo and In Vivo Performances, International Journal of Drug Delivery, 5(3), pp. 270-283
  23. Gibaldi, M. and Feldman, S., (1967), Establishment of Sink Conditions in Dissolution Rate Determinations-Theoretical Considerations and Appliparameters Cation to Nondisintegrating Dosage Forms, Journal of Pharmaceutical Sciences, 56(10), pp. 1238–1242
  24. Gibaldi, M. and Perrier, D., (1982), Pharmacokinetics, Drugs and the Pharmaceutical Sciences, 2nd Edition, Vol. 15, Marcel Dekker, Inc, New York and Basel
  25. Hemant, K.S.Y. and Shivakumar, H.G. (2010), Development of Chitosan Acetate Films for Transdermal Delivery of Propranolol Hydrochloride, Tropical Journal of Pharmaceutical Research, 9(2), pp. 197-203
  26. Herlina, R., Murhananto, J., Endah, T.L., dan Pribadi, S.T., (2002), Khasiat Manfaat Jahe Merah Si Rimpang Ajaib, Agro Media Pustaka, Jakarta
  27. Higuchi, T., (1961), Rate of Release of Medicaments from Ointment Bases Containing Drugs in Suspension, Journal of pharmaceutical science, 50(10), pp. 874-875
  28. Higuchi, T., (1962), Mechanism of Sustained-Action Medication. Theoretical Analysis of Rate of Release of Solid Drugs Dispersed in Solid Matrices, Journal of pharmaceutical science, 52(12), pp. 1145-1149
  29. Jayanudin, Barleany, D.R., Rochmadi, Wiratni, Sugiarti, A., and Kusuma, Y.A., (2013), Modification on Maceration Extraction to the Yield and Components of Red Ginger Oleoresin, Proceeding of International Conference on Chemical Engineering, Parahyangan University, December 4-5th, pp. 72-77
  30. Jayanudin, Rochmadi, Wiratni, Yulvianti, M., Barleany, D.R., and Ernayati, W., (2015), Encapsulation Red Ginger Oleoresin (Zingiber officinale var. rubrum) with Chitosan-Alginate as Wall Material using Spray Drying, Research Journal of Applied Sciences, Engineering and Technology, 10(12), pp. 1370-1378
  31. Kalam, M.A., Humayun, M., Parvez, N., Yada, S., Garg, A., Amin, S., Sultana, Y., and Ali, A., (2007), Release Kinetics of Modified Pharmaceutical Dosage Forms: A Review, Continental Journal of Pharmaceutical Sciences, 1, pp. 30-35
  32. Kimura, I.Y., Fávere, V.T., Martins, A.O., Spinelli, V.A and Josué, A., (2001), Adequacy of Isotherm Adsorption of Black 5 Reactive Dye for Crosslinked Chitosan Microspheres, Acta Scientiarum, 23(6), pp. 1313-1317
  33. Kiran, C.R., Chakka, A.K., Amma, K.P.P., Menon, A.N., Kumar, M.M.S., and Venugopalan, V.V., (2013), Influence of Cultivar and Maturity at Harvest on the Essential Oil Composition, Oleoresin and [6]-Gingerol Contents in Fresh Ginger from Northeast India, Journal of Agricultural and Food Chemistry, 61(17), pp. 4145−4154
  34. Ko, J.A, Hwang, S.J, Park, J.B., and Lee, J.S., (2002), Preparation and Characterization of Chitosan Microparticles Intende for Controlled Drug Delivery, International Journal of Pharmaceutics, 249(1-2), pp. 165-174
  35. Koeswara, S., (1995), Jahe dan Hasil Olahannya. Pustaka Sinar Harapan, Jakarta
  36. Korsmeyer, R.W., Gurny, R., Doelker, E.M., Buri, P., and Peppas, N.A., (1983), Mechanism of Solute Release from Porous Hydrophilic Polymers, International journal of pharmaceutics, 15(1), pp. 25-35
  37. Kouchak, M. and Azarpanah, A., (2015), Preparation and inVitro Evaluation of Chitosan Nanoparticles Containing Diclofenac Using the Ion-Gelation Method, Jundishapur Journal of Natural Pharmaceutical Products, 10(2), pp. 1-7
  38. Lesmes, U. and McClements, D.J., Structure-Function Relationships to Guide Rational Design and Fabrication of Particulate Food Delivery Systems, Trends in Food Science and Technology, 20(10), pp. 448-457
  39. Lun, L.C., Derong, T., and Le, L., (2008), Research on the Extracting and Anti-Oxidation Dynamic Characteristics of Ginger Oleoresin, International Journal of Food Science and Technology, 43(3), pp. 517–525
  40. Martınez, A., Arana, P., Fernandez, A., Olmo, R., Teijon, C., and Blanco, M.D., (2013), Synthesis and Characterisation of Alginate/Chitosan Nanoparticles as Tamoxifen Controlled Delivery Systems, Journal of Microencapsulation, 30(4), pp. 398–408
  41. Meng, X., Tian, F., and Yang, J., (2010), Chitosan and Alginate Polyelectrolite Complex Membranes and their Properies for Wound Dressing Application, The Journal of Materials Science: Materials in Medicine, 21(5), pp. 1751-1759
  42. Mishra, M., (2016), Handbook of Encapsulation and Controlled Release, 1-15, CRC Press Taylor & Francis Group
  43. Munin, A. and Edwards-Lévy, F., (2011), Encapsulation of Natural Poly-Phenolic Compounds: A Review, Pharmaceutics, 3(4), pp. 793–829
  44. Mbaeyi Nwaoha, M., Elizabeth, I., Okafor, Ifeanyi, G., Apochi., and Veronica, O., (2013), Production of Oleoresin from Ginger (Zingiber Officinale) Peels and Evaluation of Its Antimicrobial and Antioxidative Properties, African Journal of Microbiology Research, 7 (42), pp. 4981-4989
  45. Nedovic, V., Kalusevic, A., Manojlovic, V., Levic, S., and Bugarski, B., (2011), An Overview of Encapsulation Technologies for Food Applications, Procedia Food Science, 1, pp. 1806-1815
  46. Oboh, G., Ayodele, J.A., and Adedayo, O.A., (2012), Antioxidant and Inhibitory Effect of Red Ginger (Zingiber Officinale Var. Rubra) and White Ginger (Zingiber Officinale Roscoe) on Fe2+ Induced Lipid Peroxidation in Rat Brain in Vitro, Experimental and Toxicologic Pathology, 64,(1-2), pp. 31–36
  47. Onyenekwe, P.C., (2000), Assessment of Oleoresin and Gingerol Contents in Gamma Irradiated Ginger Rhizomes, Molecular Nutrition and Food Research, 44 (2), pp. 130–132
  48. Pinho, E., Grootveld, M., Soares, G., and Henriques, M., (2014), Cyclodextrins as Encapsulation Agents for Plant Bioactive Compounds, Carbohydrate Polymers, 101, pp. 121-135
  49. Pothakamury, U.R. and Barbosa-Cánovas, G.V., (1995), Fundamental Aspects of Controlled Release in Food, Trends in Food Science and Technology, 6, pp. 397-406
  50. Purnomo, H., Jaya, F., and Widjanarko, S.B., (2010), The Effects of Type and Time of Thermal Processing on Ginger (Zingiber Officinale Roscoe) Rhizome Antioxidant Compounds and Its Quality, International Food Research Journal, 17, pp. 335-347
  51. Rao, N.G.R., Kulkarni, U., Deshmukh, A., and Suresh, (2010), Preparation and Characterization of Ionotropic Cross-Linked Chitosan Microparticles for Controlled Release of Aceclofenac, International Journal of Pharmaceutical Sciences and Drug Research, 2(2), pp. 107-111
  52. Ritger, P.L. and Peppas, N.A., (1987), A Simple Equation for Description of Solute Release II. Fickian and Anomalous Release from Swellable Devices, Journal of control release, 5(1), pp. 37-42
  53. Peppas, N.A. and Sahlin, J.J. (1989), A Simple Equation for the Description of Solute Release. III. Coupling of Diffusion and Relaxation, International Journal of Pharmaceutics, 57, pp. 169-172
  54. Reineccius, G.A., (1994), Flavor manufacturing. Part II. Flavor encapsulation.In: Reineccius G, Source Book of Flavors, 2nd ed. Chapman & Hall, New York, Chapter 11, pp. 605–625
  55. Sezer and Akbuğa, (1999), Release Characteristics of Chitosan Treated Alginate Beads: I. Sustained Release of A Macromolecular Drug from Chitosan Treated Alginate Beads, Journal of Microencapsulation, 16 (2), pp. 195-203
  56. Shaikh, J., Bhosale, R., and Singhal, R., (2006), Microencapsulation of Black Pepper Oleoresin. Food Chemistry, 94(1), pp. 105-110
  57. Sinko, J.P., (2011), Martin's Physical Pharmacy and Pharmaceutical Sciences, Sixth Edition, Wolters Kluwer, Philadelphia, pp. 248-250
  58. Sivasothy, Y., Chong, W.K., Hamid, A., Eldeen, I.M., Sulaiman, S.F., and Awang, K., (2011), Essential Oils of Zingiber Officinale Var. Rubrum Theilade and their Antibacterial Activities, Food Chemistry, 124(2), pp. 514–517
  59. Stahl, W.M., (1973), Oleoresin Quality Analysis- Fact or Fiction?, Tropical Science, 14, pp. 335-345
  60. Vaidya, S., Bhosale, R., and Singhal R.S., (2006), Microencapsulation of Cinnamon Oleoresin by Spray Drying Using Different Wall Materials, Drying Techology, 24(8), pp. 983–992
  61. Tan, T.W., Hu, B., Xian-Hua, J., and Zhang, M., (2003), Release Behaviour of Ketoprofen from Chitosan/Alginate Microcapsules, Journal Bioactive Compatible Polymer, 18(3), pp. 207–218
  62. Wagner, J.G. (1969), Interpretation of Percent Dissolved-Time Plots Derived from In Vitro Testing of Conventional Tablets and Capsules, Journal of Pharmaceutical Sciences, 58(10), pp. 1253-1257
  63. Wohlmuth, H., Leach, D.N., Smith, M.K., and Myers, S., (2005), Gingerol Content of Diploid and Tetraploid Clones of Ginger (Zingiber officinale Roscoe), Journal of Agricultural and Food Chemistry, 53(14), pp. 5772-5778
  64. Yeh, H.Y, Chuang, C.H., Chen, H.C., Wan, C.J., Chen, T.L., and Lin, L.Y., (2014), Bioactive Components Analysis of Two Various Gingers (Zingiber Officinale Roscoe) and Antioxidant Effect of Ginger Extracts, LWT - Food Science and Technology, 55(1), pp. 329-334
  65. Zarate, R. and Yeoman, M.M., (1996), Changes in the Amounts of [6] Gingerol and Derivatives during A Culture Cycle of Ginger, Zingiber officinale. Plant Science, 121(1), pp. 115-122

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