Synthesis of Some Distinct Curcumin-Based Pyrano [2,3-D] Pyrimidines with Barbituric Acid, Cinnamaldehyde, and Benzaldehyde

Kam Natania; Riviana Susanto; Antonius Herry Cahyana

doi:10.14710/reaktor.1.1.1-8

DOI: https://doi.org/10.14710/reaktor.1.1.1-8

Synthesis of Some Distinct Curcumin-Based Pyrano [2,3-D] Pyrimidines with Barbituric Acid, Cinnamaldehyde, and Benzaldehyde

*Kam Natania

- Research and Quality Control Laboratory, Food Technology Department, Universitas Pelita Harapan, Indonesia

Riviana Susanto - Department of Food Technology, Universitas Pelita Harapan, Indonesia

Antonius Herry Cahyana

- Department of Chemistry, Universitas Indonesia, Indonesia

Received: 26 Aug 2022; Published: 6 Jun 2023.

Citation Format:

Abstract

Curcumin is a powerful radical oxygen scavenger. The modification of of curcumin’s α, β-unsaturated 1,3-diketone moiety can be carried out to improve its physicochemical stability and functionality. This research aimed to conduct a modification of curcumin structure and to study the antioxidant activity of the modified curcumin-based compound. The modified curcumin made from a combination of benzaldehyde and cinnamaldehyde, using barbituric acid and combination of citric acid as catalyst and ethanol as solvent. The combination of ethanol solvent and 20 mmol% citric acid catalyst produce the highest yield of curcumin product which has a yield of 99.3581±0.2873% and was chosen as the best combination for the next modification using different β-diketone compounds. In the following stage, the mixture was reacted with either benzaldehyde or cinnamaldehyde. Yield, TLC, and antioxidant activity parameters were assessed for all modified products and were accompanied by their characterization using UV-Vis spectrophotometry. This study showed that curcumin cinnamaldehyde had a yield of 47.4831±2.7032%, a maximum wavelength of 416 nm, and antioxidant activity of IC50 18.2130±2.8766 mg/L with a molecular mass of 594 m/z.

Keywords: antioxidant activity, benzaldehyde, cinnamaldehyde, curcumin, dimedone, modification

Fulltext View|Download

Funding: Universitas Pelita Harapan

Article Metrics:

Article Info

Section: Research Article

Language : EN

In Volume 23 No.1 April 2023

Recent articles

Redesign of Boiler Heat Recovery Steam Generator (HRSG) on The Utilization of Waste Gas in The Cement Industry Chitosan-modified fly-ash/kaolin ceramic membrane for enhancing FOG-water separation performance Physicochemical Characteristics of Butterfly Pea Flower Petals Steep Obtained at Different Steeping Temperature and Time More recent articles

Most cited articles

ISOTHERMAL PYROLYSIS OF KRAFT PULP MILL SLUDGE APLIKASI SORBITOL PADA PRODUKSI BIODEGRADABLE FILM DARI NATA DE CASSAVA APPLICATION OF PHYTOREMEDIATION FOR HERBAL MEDICINE WASTE AND ITS UTILIZATION FOR PROTEIN PRODUCTION PERFORMANCE OF NEWLY CONFIGURED SUBMERGED MEMBRANE BIOREACTOR FOR AEROBIC INDUSTRIAL WASTEWATER TREATMENT Synthesized of Double Layer Thin Film ZnO/ZnO:Ag by Sol-Gel Method for Direct Blue 71 Photodegradation More cited articles

Last update:

No citation recorded.

Last update: 2025-02-27 17:35:51

No citation recorded.

In order for REAKTOR to publish and disseminate research articles, we need non-exclusive publishing rights (transferred from the author(s) to the publisher). This is determined by a publishing agreement between the Author(s) and REAKTOR. This agreement deals with transferring or licensing the publishing copyright to REAKTOR while Authors still retain significant rights to use and share their published articles. REAKTOR supports the need for authors to share, disseminate, and maximize the impact of their research and these rights in any databases.

As a journal author, you have the right to use your article for many purposes, including by your employing institute or company. These Author rights can be exercised without the need to obtain specific permission. Authors publishing in BCREC journals have wide rights to use their works for teaching and scholarly purposes without needing to seek permission, including, but not limited to:

use for classroom teaching by the Author or the Author's institution and presentation at a meeting or conference and distributing copies to attendees;
use for internal training by the author's company;
distribution to colleagues for their research use;
use in a subsequent compilation of the author's works;
inclusion in a thesis or dissertation;
reuse of portions or extracts from the article in other works (with full acknowledgment of the final article);
preparation of derivative works (other than commercial purposes) (with full acknowledgment of the final article);
voluntary posting on open websites operated by the author or the author’s institution for scholarly purposes,

(but it should follow the open access license of Creative Common CC-by-SA License).

Authors/Readers/Third Parties can copy and redistribute the material in any medium or format and remix, transform, and build upon the material for any purpose, even commercially. Still, they must give appropriate credit (the name of the creator and attribution parties (authors detail information), a copyright notice, an open access license notice, a disclaimer notice, and a link to the material), provide a link to the license, and indicate if changes were made (Publisher indicates the modification of the material (if any).

Authors/Readers/Third Parties can read, print and download, redistribute or republish the article (e.g., display in a repository), translate the article, download for text and data mining purposes, reuse portions or extracts from the article in other works, sell or re-use for commercial purposes, remix, transform, or build upon the material, they must distribute their contributions under the same license as the original Creative Commons Attribution-ShareAlike (CC BY-SA).