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Acid-base Management in Cardiopulmonary Bypass

SM Anestesi Bedah Kardiovaskular, RS Jantung dan Pembuluh Darah Harapan Kita, Jakarta, Indonesia

Received: 23 Aug 2020; Published: 1 Jul 2021.
Open Access Copyright 2021 JAI (Jurnal Anestesiologi Indonesia)

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Abstract

Cardiopulmonary bypass (CPB) merupakan alat penunjang fungsi sirkulasi dan pernapasan pasien yang biasa digunakan ketika menjalani pembedahan jantung atau pembuluh darah besar. Selama prosedur CPB, kondisi hipotermia dipertahankan untuk menurunkan kebutuhan oksigen dan laju metabolisme. Kondisi hipotermia akan mempengaruhi keseimbangan asam-basa pada tubuh. Manajemen asam-basa selama prosedur CPB dicapai dengan menggunakan metode a-stat atau pH-stat. Pada metode a-stat, manajemen asam-basa dilakukan dengan menjaga pHa 7.4 dan PaCO2 40 mmHg pada suhu 37oC tanpa penambahan CO2 oksigen untuk menjaga total CO2 tetap konstan. Sedangkan, pada metode pH-stat, diberikan CO2 oksigen untuk menjaga PaCO2 40 mmHg dan pHa 7.4 secara in vivo. Masih banyak perdebatan terkait waktu penerapan masing-masing metode. Pada level mikrosirkulasi, manajemen a-stat terbukti memberikan keuntungan pada otak dan mengurangi insidensi postoperative cerebral dysfunction. Sedangkan, metode pH-stat dilaporkan meningkatkan risiko emboli otak, sehingga tidak disarankan untuk pasien yang memiliki risiko tinggi gangguan aliran darah otak. Namun, terdapat pula laporan yang menyatakan pH-stat bermanfaat pada operasi bedah jantung anak. Berdasarkan hal itu, usia pasien dapat menentukan waktu penggunaan metode a-stat dan pH-stat. Satu indikasi primer penggunaan pH-stat adalah selama proses pendinginan saat deep hypothermic circulatory arrest (DHCA), sedangkan metode a-stat lebih baik digunakan selama selective cerebral perfusion (SCP) dan rewarming.

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Keywords: -stat; manajemen asam basa; cardiopulmonary bypass; hipotermia; pH-stat

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  1. Sarkar M, Prabhu V. Basics of cardiopulmonary bypass. Indian J Anaesth. 2017;61(9):760–7
  2. Davis LK, Reed H. Cardiopulmonary Bypass and Mechanical Support. 4th ed. Gravlee GP, editor. Wolters Kluwer;
  3. Harris B, Andrews PJD, Murray GD, Forbes J, Moseley O. Systematic review of head cooling in adults after traumatic brain injury and stroke. Vol. 16, Health Technology Assessment. 2012
  4. Meng L, Flexman A. Central nervous system disease. In: Pardo MC, Miller RD, editors. Basics of anesthesia. 7th ed. Philadelphia: Elsevier; 2018. p. 511–3
  5. Hogue CW, Palin CA, Arrowsmith JE. Cardiopulmonary bypass management and neurologic outcomes: An evidence-based appraisal of current practices. Vol. 103, Anesthesia and Analgesia. Lippincott Williams and Wilkins; 2006. p. 21–37
  6. Bacher A. Effects of body temperature on blood gases. In: Applied Physiology in Intensive Care Medicine. 7th ed. Berlin: Springer; 2009. p. 49–52
  7. Fujii S, Murkin JM. Hensley’s Practical Approach to Cardiothoracic Anesthesia. 6th ed. Gravlee GP, Shaw AD, Bartels K, editors. Mexico: Wolters Kluwer; 2019
  8. Duebener LF, Hagino I, Sakamoto T, Mime L ben, Stamm C, Zurakowski D, et al. Effects of pH management during deep hypothermic bypass on cerebral microcirculation: Alpha-stat versus pH-stat. Circulation. 2002 Sep 24;106(13 SUPPL.)
  9. Chaney B, Emmady PD. Blood Gas Temperature Correction [Internet]. StatPearls Publishing. 2020 [cited 2020 Aug 13]. Available from: https://www.ncbi.nlm.nih.gov/books/NBK557769/
  10. Nauphal M, El-Khatib M, Taha S, Haroun-Bizri S, Alameddine M, Bataka A. Effect of alpha-stat vs. pH-stat strategies on cerebral oximetry during moderate hypothermic cardiopulmonary bypass. Eur J Anaesth. 2007;24:15–9
  11. Abdul Aziz KA, Meduoye A. Is pH-stat or alpha-stat the best technique to follow in patients undergoing deep hypothermic circulatory arrest? Interactive Cardiovascular and Thoracic Surgery. 2010;10(2):271–82
  12. Jonas RA. Technique of circulatory arrest makes a difference. Vol. 156, Journal of Thoracic and Cardiovascular Surgery. Mosby Inc.; 2018. p. 40–1
  13. Grocott HP, Stafford-Smith M, Mora-Mangano CT. Kaplan’s Essentials of Cardiac Anesthesia for Cardiac Surgery. 2nd ed. Kaplan JA, Cronin B, Maus T, editors. Philadelphia: Elsevier; 2018
  14. Liu LL. Basics of Anesthesia. 7th ed. Pardo MC, Miller RD, editors. Philadelphia: Elsevier; 2018
  15. Pokela M, Dahlbacka S, Biancari F, Vainionpä V, Kiviluoma K, Kaakinen T, et al. pH-Stat Versus Alpha-Stat Perfusion Strategy During Experimental Hypothermic Circulatory Arrest: A Microdialysis Study. 2003
  16. Sakamoto T, Kurosawa H, Shin’oka T, Aoki M, Isomatsu Y, Griepp RB, et al. The influence of pH strategy on cerebral and collateral circulation during hypothermic cardiopulmonary bypass in cyanotic patients with heart disease: Results of a randomized trial and real-time monitoring. Journal of Thoracic and Cardiovascular Surgery. 2004;127(1):12–9

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