Efektivitas Midazolam Untuk Pencegahan Mual Muntah Pascabedah Pada Prosedur Laparaskopi

Tujuan: mengevaluasi pemberian midazolam sebagai agen anti emetik dan anxiolitik
Metode: Empat puluh delapan pasien yang akan menjalani prosedur pembedahan laparaskopi elektif secara acak dibagi menjadi dua kelompok. Setelah diberikan obat premedikasi, kelompok M (n=24) diberikan midazolam 35 μg/kgBB intravena kelompok O (n=24) diberikan ondansetron 4 mg intravena. Selama prosedur anestesi, pemakaian opioid dan lama operasi dicatat. Kemudian kejadian mual muntah pasca bedah diamati dan dicatat selama periode 8 jam pascabedah.
Hasil: Kejadian mual muntah setelah prosedur pembedahan laparaskopi pada penelitian ini diukur menggunakan skor PONV dengan interval 30 menit selama di ruang pemulihan dan setiap 1 jam di ruang perawatan selama 8 jam pasca bedah. Pada penilitian ini, terdapat perbedaan yang bermakna diantara kedua kelompok dengan hasil p=0,022 (p<0,05) pada waktu pengamatan P2 (60 menit pasca bedah) .
Kesimpulan: Midazolam 35 μg/kgBB setelah premedikasi pada anestesi umum pada prosedur pembedahan laparaskopi elektif menurunkan kejadian mual muntah pascabedah terutama pada 1 jam pasca bedah.
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Last update: 2021-03-07 13:09:49
Last update: 2021-03-07 13:09:47
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