Perbandingan Efektivitas Spray Mometasone Furoat dan Deksamethason Intravena dalam Mengurangi Nyeri Tenggorokan setelah Operasi pada Anestesi Umum Intubasi Endotrakeal

Dian Wirdiyana -  Bagian Ilmu Anestesi, Perawatan Intensif Dan Manajemen Nyeri, Fakultas Kedokteran, Universitas Hasanuddin Makassar, Indonesia
*Wahyudi Wahyudi -  Bagian Ilmu Anestesi, Perawatan Intensif Dan Manajemen Nyeri, Fakultas Kedokteran, Universitas Hasanuddin Makassar, Indonesia
Muh Ramli Achmad -  Bagian Ilmu Anestesi, Perawatan Intensif Dan Manajemen Nyeri, Fakultas Kedokteran, Universitas Hasanuddin Makassar, Indonesia
Published: 1 Nov 2013.
Open Access
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Article Info
Section: Penelitian
Language: ID
Full Text:
In Vol 5, No 3 (2013): Jurnal Anestesiologi Indonesia
Statistics: 383 120
Abstract
Latar belakang : Banyak faktor pada intubasi endotrakeal yang dapat menyebabkan nyeri tenggorokan setelah operasi sebagai akibat dari trauma pada mukosa. Spray mometasone furoat adalah kortikosteroid potensi sedang yang dapat mencegah influx sel-sel inflamasi ke dalam mukosa. Deksamethason adalah kortikosteroid potensi kuat dengan sifat analgetik dan antiinflamasi.Tujuan:  meneliti perbandingan efektivitas spray mometasone furoat dan deksamethason intravena dalam mengurangi nyeri tenggorokan setelah operasi pada anestesi umum intubasi endotrakeal. Metode : Penelitian ini bersifat double blind. Lima puluh delapan pasien yang akan menjalani operasi dengan anestesi umum intubasi endotrakeal dipilih secara acak. Sampel yang memenuhi kriteria inklusi di bagi dalam 2 grup. Grup M (n = 29) diberikan spray mometasone furoat 100 mcg pada cuff pipa endotrakeal, pita suara, epiglottis, dan faring saat intubasi endotrakel dan grup D (n = 29) diberikan deksamethason 10 mg intravena 30 menit sebelum intubasi endotrakeal. Dilakukan penilaian terhadap insiden dan derajat nyeri tenggorokan pada jam ke-1, ke-6, dan ke- 24 setelah ektubasi. Analisis statistik dilakukan dengan uji mann-whitney dan chi square, dengan p < 0,05 bermakna secara signifikan. Hasil : Terdapat perbedaan yang bermakna baik insiden maupun derajat nyeri tenggorokan pada jam ke-1 setelah ekstubasi pada kedua kelompok (p<0,05). Tidak terdapat perbedaan bermakna baik insiden maupun derajat nyeri tenggorokan pada jam ke-6 dan ke-24 setelah ekstubasi pada kedua kelompok (p>0,05). Kesimpulan : Spray mometasone furoat dapat mengurangi nyeri tenggorokan setelah operasi anestesi umum intubasi endotrakeal.
Keywords
nyeri tenggorokan; intubasi endotrakeal; spray mometasone; deksamethason intravena

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