Perbandingan Efektivitas Spray Mometasone Furoat dan Deksamethason Intravena dalam Mengurangi Nyeri Tenggorokan setelah Operasi pada Anestesi Umum Intubasi Endotrakeal

Dian Wirdiyana  -  Bagian Ilmu Anestesi, Perawatan Intensif Dan Manajemen Nyeri, Fakultas Kedokteran, Universitas Hasanuddin, Indonesia
*Wahyudi Wahyudi  -  Bagian Ilmu Anestesi, Perawatan Intensif Dan Manajemen Nyeri, Fakultas Kedokteran, Universitas Hasanuddin, Indonesia
Muh Ramli Achmad  -  Bagian Ilmu Anestesi, Perawatan Intensif Dan Manajemen Nyeri, Fakultas Kedokteran, Universitas Hasanuddin, Indonesia
Published: 1 Nov 2013.
Open Access
Citation Format:
Article Info
Section: Penelitian
Language: ID
In Vol 5, No 3 (2013): Jurnal Anestesiologi Indonesia
Statistics: 533 597
Abstract
Latar belakang : Banyak faktor pada intubasi endotrakeal yang dapat menyebabkan nyeri tenggorokan setelah operasi sebagai akibat dari trauma pada mukosa. Spray mometasone furoat adalah kortikosteroid potensi sedang yang dapat mencegah influx sel-sel inflamasi ke dalam mukosa. Deksamethason adalah kortikosteroid potensi kuat dengan sifat analgetik dan antiinflamasi.Tujuan:  meneliti perbandingan efektivitas spray mometasone furoat dan deksamethason intravena dalam mengurangi nyeri tenggorokan setelah operasi pada anestesi umum intubasi endotrakeal. Metode : Penelitian ini bersifat double blind. Lima puluh delapan pasien yang akan menjalani operasi dengan anestesi umum intubasi endotrakeal dipilih secara acak. Sampel yang memenuhi kriteria inklusi di bagi dalam 2 grup. Grup M (n = 29) diberikan spray mometasone furoat 100 mcg pada cuff pipa endotrakeal, pita suara, epiglottis, dan faring saat intubasi endotrakel dan grup D (n = 29) diberikan deksamethason 10 mg intravena 30 menit sebelum intubasi endotrakeal. Dilakukan penilaian terhadap insiden dan derajat nyeri tenggorokan pada jam ke-1, ke-6, dan ke- 24 setelah ektubasi. Analisis statistik dilakukan dengan uji mann-whitney dan chi square, dengan p < 0,05 bermakna secara signifikan. Hasil : Terdapat perbedaan yang bermakna baik insiden maupun derajat nyeri tenggorokan pada jam ke-1 setelah ekstubasi pada kedua kelompok (p<0,05). Tidak terdapat perbedaan bermakna baik insiden maupun derajat nyeri tenggorokan pada jam ke-6 dan ke-24 setelah ekstubasi pada kedua kelompok (p>0,05). Kesimpulan : Spray mometasone furoat dapat mengurangi nyeri tenggorokan setelah operasi anestesi umum intubasi endotrakeal.
Keywords: nyeri tenggorokan; intubasi endotrakeal; spray mometasone; deksamethason intravena

Article Metrics:

  1. Thomas S, Beevi S. Dexamethasone reduces the severity of postoperative sore throat. Can J Anesth. 2007;54(11):897-901
  2. Vipin NK. Post intubation sore throat: a comparative study between intracuff alkalinized lignocaine and intracuff plain lignocaine. Dissertation. St. Johns Medical College and Hospital. Bangalore. 2007
  3. Ahmed A, Abbasi S, Ghafoor H, Ishaq M. Postoperative sore throat after elective surgical procedurs. J Ayub Med Coll Abbottabad. 2007;19(2):12-4
  4. Narasethakamol A, Techanivate A, Saothongthong J, Yurakate N, Cousnit P. Application of Mometasone spray to reduce sore throat after tracheal intubation. J Med Assoc Thai. 2011; 94(8):958-64
  5. Hung NK, Wu CT, Chan SM, Lu CH, Huang YS, Yeh CC, Lee MS, Cherng CH. Effect on postoperative sore throat of spraying the endotracheal tube cuff with benzydamine hydrochloride, 10% lidocaine, and 2% lidocaine. Anesth Analg. 2010;10(10):1-5
  6. Sumathi PA, Shenoy T, Ambareshaa M, Krisna HM. Controlled comparison between betamethasone gel and lidocaine jelly applied over trachea tube to reduce postoperative sore throat, cough, and hoarseness of voice. British Journal of Anesthesia. 2008;100(2):215-8
  7. Ayoup CM, Ghobashi A, Koch ME, McGrimley L, Pascale V, Qadir S, Ferneini EM, Silverman DG. Widespread application of topical steroids to decrease sore throat, hoarseness, and cough after tracheal intubation. Anesth Analg. 1998;87:714-6
  8. Bagchi D, Mandal MC, Das S, Sahoo T, Basu SR, Sarkar S. Efficacy of intravenous dexamethasone to reduce incidence of postoperative sore throat: A prospective randomized controlled trial. Journal of Anaesthesiology Clinical Pharmacology. 2012;28(4):477-80
  9. Park SY, Kim SH, Lee AR, Cho SH, Chae WS, Jin HC, Lee JS, Kim YI. Prophylactic effect of dexamethasone in reducing postoperative sore throat. Korean J Anesthesiol. 2010;58(1):15-9
  10. Dollo G, Estebe JP, LeCorre P et all. Endotracheal pipa cuffs filled with lidocaine as a drug delivery system: in vitro dan in vivo investigations. Eur J Pharm Scien. 2001;13:319- 23
  11. Sugimoto Y, Kawamoto E, Chen Z et all. A new model of allergic rhinitis in rats by topical sensitization and evaluation H1-receptor antagonist. Immunopharmacology. 2000;48:1- 7
  12. Ogawa M, Tsumoro T, Takubo M et all. Effect of mometasone furoat on nasal congestion model in rats. Pharmacology. 2009;84:99-103
  13. Frieri M, Therattil J, Chavarria V et all. Effect of mometasone furoat on early and late phase inflammation in patients with seasonal allergic rhinitis. Ann Allergy Asthma Immuno. 1998;81:431-7
  14. Calvey N, Williams N. Corticosteroid and hipoglicemic agents. In: Calvey N, Williams N, editors. Principles and practice of pharmacology for anaesthetists. 5thEdisi . 2008. p. 329-31
  15. Neal JM. Glucocorticoid. In: Neal JM, editors. Medical pharmacology at a glance division of pharmacology and therapeutic kings collage london. Ed 4th . 2002. p. 17
  16. Castilho EC, Braz JR, Cataneo AJ, Martins RH, Gregorio EA, Monteiro ER. Effects of tracheal tube cuff limit pressure (25 cmH2O) and seal pressure on tracheal mucosa of dogs. Revista Brasileira de Anestesiologia. 2003;53(6):749-54

The Authors submitting a manuscript do so on the understanding that if accepted for publication, copyright of the article shall be assigned to JAI (Jurnal Anestesiologi Indonesia) and Department of Anesthesiology and Intensive Theraphy, Faculty of Medicine, Diponegoro University as publisher of the journal. Copyright encompasses exclusive rights to reproduce and deliver the article in all form and media, including reprints, photographs, microfilms, and any other similar reproductions, as well as translations. 

JAI (Jurnal Anestesiologi Indonesia) and Department of Anesthesiology and Intensive Theraphy, Faculty of Medicine, Diponegoro University and the Editors make every effort to ensure that no wrong or misleading data, opinions or statements be published in the journal. In any way, the contents of the articles and advertisements published in JAI (Jurnal Anestesiologi Indonesia) are the sole and exclusive responsibility of their respective authors and advertisers.

The Copyright Transfer Form can be downloaded here:[Copyright Transfer Form JAI]. The copyright form should be signed originally and send to the Editorial Office in the form of original mail, scanned document:  

 

Uripno Budiono (Editor-in-Chief)

Editorial Office of JAI (Jurnal Anestesiologi Indonesia)

Department of Anesthesiology and Intensive Theraphy, Faculty of Medicine, Diponegoro University/ Dr. Kariadi General Hospital Medical Center (RSUP Dr. Kariadi)

Jl. Dr. Soetomo No. 16 Semarang, Central Java, Indonesia, 50231

Telp. : (024) 8444346

Email : janestesiolgo@gmail.com