Efek Dexmedetomidine 0,2 ug/kgbb Intravena terhadap Insiden Delirium saat Pulih Sadar dari Anestesi Umum pada Pasien Pediatrik

*Cahya Hendrawan -  Bagian Anestesiologi, Perawatan Intensif dan Manajemen Nyeri, Fakultas Kedokteran, Universitas Hasanuddin Makassar, Indonesia
Syafri Kamsul Arif -  Bagian Anestesiologi, Perawatan Intensif dan Manajemen Nyeri, Fakultas Kedokteran, Universitas Hasanuddin Makassar, Indonesia
Published: 1 Jul 2013.
Open Access
Citation Format:
Article Info
Section: Penelitian
Language: ID
Full Text:
In Vol 5, No 2 (2013): Jurnal Anestesiologi Indonesia
Statistics: 422 49
Abstract
Latar Belakang : Dexmedetomidine memberikan efek sedasi, analgesia, dan anxiolitiksetelah pemberian intravena. Isofluran dan sevofluran dihubungkan dengan angkakejadian delirium saat pulih sadar dari anestesi umum pada pasien pediatrik. Padapenelitian dengan menggunakan placebo sebagai kontrol, kami mengevaluasi efek daridosis tunggal dexmedetomidine pada delirium saat pulih sadar dari anestesi umumpada pasien pediatrik yang menjalani pembedahan elektif menggunakan anestesiumum dengan isofluran.
Metode : Pada penelitian acak tersamar ganda ini , 46 anak (usia 3-10 tahun) dipilihsecara acak mendapatkan dexmedetomidin 0,2ug/kgBB atau placebo pada akhirpembedahan. Semua pasien mendapatkan obat anestesi yang standar. Setelahpembedahan, nilai delirium saat pulih sadar dari anestesi umum diukur sampai 1 jampascabedah. Waktu ekstubasi, waktu pulih sadar, dan efek samping daridexmedetomidine dicatat. Setelah pembedahan nyeri pasien diukur denganmenggunakan objective pain scale (OPS) .
Hasil : Nilai delirium saat pulih sadar dari anestesi umum pada kelompokdexmedetomidine lebih baik daripada kelompok placebo (P<0,05). Nilai nyeri samapada kedua kelompok (P>0,05). Waktu ekstubasi dan waktu pulih sadar lebih panjangpada kelompok dexmedetomidin tetapi tidak bermakna secara statistik (P>0,05). Tidakada efek samping (hipotensi dan bradikardi) pada kedua kelompok.
Kesimpulan : Kami menyimpulkan bahwa Dexmedetomidine 0,2ug/kgBB intravenadapat mengurangi insiden delirium saat pulih sadar dari anestesi umum denganisofluran pada anak yang menjalani pembedahan elektif.
Keywords
dexmedetomidine; delirium; isofluran; anesthesia

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