Pengaruh Induksi Propofol dan Ketamin terhadap Kadar Procalcitonin Plasma

*Aunun Rofiq -  Bagian Anestesiologi dan Terapi Intensif, Fakultas Kedokteran Universitas Diponegoro/ RSUP Dr. Kariadi Semarang, Indonesia
Johan Arifin -  Bagian Anestesiologi dan Terapi Intensif, Fakultas Kedokteran Universitas Diponegoro/ RSUP Dr. Kariadi Semarang, Indonesia
Witjaksono Witjaksono -  Bagian Anestesiologi dan Terapi Intensif, Fakultas Kedokteran Universitas Diponegoro/ RSUP Dr. Kariadi Semarang, Indonesia
Published: 1 Jul 2013.
Open Access
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Article Info
Section: Penelitian
Language: ID
Full Text:
Statistics: 330 54
Abstract
Latar belakang: Procalcitonin merupakan salah satu petanda respon inflamasiterhadap infeksi. Obat induksi anestesi dapat mempengaruhi kadar procalcitoninplasma.
Tujuan: Menilai pengaruh propofol dan ketamin terhadap kadar procalcitonin dalaminduksi general anestesi.
Metode: Studi quasi experimental terhadap 16 subjek yang menjalani generalanestesi. Sampel dibagi menjadi grup 1 yang mendapatkan propofol dengan dosis2,5 mg/kgbb intravena dan grup 2 yang mendapatkan ketamin dengan dosis 2 mg/kgbbintravena sebagai obat induksi anestesi selama prosedur penelitian, anestesi rumatanO2 dan N2O dengan rasio 50%:50%. Sampel darah subjek diambil sebelum induksi,jam ke-4 dan jam ke -24.
Hasil: Didapatkan perbedaaan kadar procalcitonin bermakna sebelum dan sesudahperlakuan pada kelompok propofol (K1) (p=0,008) dan perbedaan tidak bermaknapada kelompok ketamin (K2) (p=1,00). Nilai tengah kadar procalcitonin K1 dan K2adalah 0,175±0,1 dan 0,05±0,05. Propofol menyebabkan peningkatan kadarprocalcitonin lebih tinggi dibandingkan ketamin (p=0,053).
Kesimpulan: Propofol secara bermakna meningkatkan kadar procalcitonindibandingkan ketamin
Keywords
propofol; ketamin; procalcitonin; induksi; general anestesi

Article Metrics:

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