1Bagian Anestesiologi dan Terapi Intensif, Fakultas Kedokteran Universitas Diponegoro/ RSUP Dr. Kariadi, Indonesia
2Semarang, Indonesia
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@article{JAI6412, author = {Aunun Rofiq and Johan Arifin and Witjaksono Witjaksono}, title = {Pengaruh Induksi Propofol dan Ketamin terhadap Kadar Procalcitonin Plasma}, journal = {JAI (Jurnal Anestesiologi Indonesia)}, volume = {5}, number = {2}, year = {2013}, keywords = {propofol; ketamin; procalcitonin; induksi; general anestesi}, abstract = { Latar belakang: Procalcitonin merupakan salah satu petanda respon inflamasi terhadap infeksi. Obat induksi anestesi dapat mempengaruhi kadar procalcitonin plasma. Tujuan: Menilai pengaruh propofol dan ketamin terhadap kadar procalcitonin dalam induksi general anestesi. Metode: Studi quasi experimental terhadap 16 subjek yang menjalani general anestesi. Sampel dibagi menjadi grup 1 yang mendapatkan propofol dengan dosis 2,5 mg/kgbb intravena dan grup 2 yang mendapatkan ketamin dengan dosis 2 mg/kgbb intravena sebagai obat induksi anestesi selama prosedur penelitian, anestesi rumatan O2 dan N2O dengan rasio 50%:50%. Sampel darah subjek diambil sebelum induksi, jam ke-4 dan jam ke -24. Hasil: Didapatkan perbedaaan kadar procalcitonin bermakna sebelum dan sesudah perlakuan pada kelompok propofol (K1) (p=0,008) dan perbedaan tidak bermakna pada kelompok ketamin (K2) (p=1,00). Nilai tengah kadar procalcitonin K1 dan K2 adalah 0,175±0,1 dan 0,05±0,05. Propofol menyebabkan peningkatan kadar procalcitonin lebih tinggi dibandingkan ketamin (p=0,053). Kesimpulan: Propofol secara bermakna meningkatkan kadar procalcitonin dibandingkan ketamin }, issn = {2089-970X}, pages = {101--106} doi = {10.14710/jai.v5i2.6412}, url = {https://ejournal.undip.ac.id/index.php/janesti/article/view/6412} }
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