Pengaruh Induksi Propofol dan Ketamin terhadap Kadar Procalcitonin Plasma

*Aunun Rofiq  -  Bagian Anestesiologi dan Terapi Intensif, Fakultas Kedokteran Universitas Diponegoro/ RSUP Dr. Kariadi, Indonesia
Johan Arifin  -  Bagian Anestesiologi dan Terapi Intensif, Fakultas Kedokteran Universitas Diponegoro/ RSUP Dr. Kariadi, Indonesia
Witjaksono Witjaksono  -  Bagian Anestesiologi dan Terapi Intensif, Fakultas Kedokteran Universitas Diponegoro/ RSUP Dr. Kariadi, Indonesia
Published: 1 Jul 2013.
Open Access
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Article Info
Section: Penelitian
Language: ID
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Statistics: 431 240
Latar belakang: Procalcitonin merupakan salah satu petanda respon inflamasiterhadap infeksi. Obat induksi anestesi dapat mempengaruhi kadar procalcitoninplasma.
Tujuan: Menilai pengaruh propofol dan ketamin terhadap kadar procalcitonin dalaminduksi general anestesi.
Metode: Studi quasi experimental terhadap 16 subjek yang menjalani generalanestesi. Sampel dibagi menjadi grup 1 yang mendapatkan propofol dengan dosis2,5 mg/kgbb intravena dan grup 2 yang mendapatkan ketamin dengan dosis 2 mg/kgbbintravena sebagai obat induksi anestesi selama prosedur penelitian, anestesi rumatanO2 dan N2O dengan rasio 50%:50%. Sampel darah subjek diambil sebelum induksi,jam ke-4 dan jam ke -24.
Hasil: Didapatkan perbedaaan kadar procalcitonin bermakna sebelum dan sesudahperlakuan pada kelompok propofol (K1) (p=0,008) dan perbedaan tidak bermaknapada kelompok ketamin (K2) (p=1,00). Nilai tengah kadar procalcitonin K1 dan K2adalah 0,175±0,1 dan 0,05±0,05. Propofol menyebabkan peningkatan kadarprocalcitonin lebih tinggi dibandingkan ketamin (p=0,053).
Kesimpulan: Propofol secara bermakna meningkatkan kadar procalcitonindibandingkan ketamin
propofol; ketamin; procalcitonin; induksi; general anestesi

Article Metrics:

  1. Danish MA. Dr Azam’s Notes in Anesthesiology. Bangalore: Anesthesiology & Critical Care Department B.M.Jain Hospital;2010. available from: (accessed 18 Jun 2012)
  2. Balk RA. Severe Sepsis and Septic Shock, Definition, Epidemiology and Clinical Manifestation. Crit Care Clin 2000;16 (2)179-92.
  3. Delinger RP. Surviving Sepsis Compaign Guidelines for Management of Severe Sepsis and septic Shock. Crit Care Med 2004; 32: 858-873
  4. Pohan HT. Pemeriksaan Procalcitonin untuk Diagnosis Infeksi Berat. In: Pohan HT, Widodo D, editor. Penyakit Infeksi. Jakarta: FKUI; 2004. P. 32-9
  5. Reinhart K, Karzai W. Procalcitonin as a marker of the systemic inflammatory response to infection. Intensive Care Med. 2000 Sep;26(9):1193-200
  6. Meisner M, Brunkhorst FM, Reith H, Schmidt J. Clinical Experiences with a New Semi-Quantitative Solid Phase Immunoassay for Rapid Measurement of Procalcitonin. Clin Chem Lab Med 2000; 38 (10): 989-95
  7. Simon L, Gauvin F, Amre DK, et al. Serum Procalcitonin and C-Reaktive Protein Levels as Marker of Bacterial Infection : A Systematic Review and Meta-analysis. Clinical Infectious Diseases 2004; 39: 206 – 17
  8. O'Connor E, Venkatesh B, lipman J, et al. Procalcitonin in Critical Illness. Critical Care and Resuscitation 2001; 3: 236-243
  9. Trapani G, Altomare C, Liso G, Sanna E, Biggio G. Propofol in anesthesia. Mechanism of action, structure-activity relationships and drug delivery. Curr Med Chem. 2000 Feb;7(2):249-71
  10. Stoelting RK, Hillier SC, Pharmacology & Physiology in Anesthetic Practice, 4th edition, Philadelphia : Lippincott; 2006.
  11. Ismanoe G. The Role of Cytokine in The Pathobiology of Sepsis : proceeding of the 2nd Indonesian Sepsis Forum. March 7th-9th, 2008, Surakarta : UNS Press; 2008
  12. Susanne C, Peter F, Joerg M, Klaus P. Effect of sevoflurane and propofol on procalcitonin and C-reactive protein concentration in patients undergoing off-pum coronary artery bypass graft surgery. Anesthesiology 2002; 96: A155.
  13. Bozeman WP, Kleiner DM, Huggett V. A comparison of rapid-sequence intubation and etomidate-only intubation in the prehospital air medical setting. Prehosp Emerg Care. 2006; 10(1): 8-13.
  14. Dosow V.V, Haas A, Kastrup M, Geyer T, Spies D. Influence of remifentanil versus fentanyl analgesia on the perioperative course of plasma procalcitonin levels in patients undergoing cardiac surgery. Anesthesiology 2005; 103: A320.
  15. Aalto H, Takala A, Kautiainen H. Laboratory markers of systemic inflammationas predictors of bloodstream infection inacutely ill patients admitted to hospital in medical emergency. Eur J Clin Microbiol Infect Dis 2004; 23:699–704