skip to main content

Pengaruh pemberian susu almond terhadap glukosa darah puasa pada tikus diabetes

Departemen Ilmu Gizi, Fakultas Kedokteran, Universitas Diponegoro, Indonesia

Received: 31 Oct 2018; Published: 14 Jun 2019.

Citation Format:

Background: Type 2 Diabetes Mellitus is a group of metabolic diseases with characteristic hyperglycemia that occurs due to abnormalities in insulin secretion and insulin action. Diet plus high fiber can help control glucose levels. Almond contains fiber, vitamin E, and magnesium that contributes to the fasting blood glucose levels. This study aimed to analyze the effect of almond milk to the fasting blood glucose diabetic rats.

Method: This study used an experimental design with pre-post test control group design. The sample were Rattus norvegicus Wistar which were divided into 4 groups: K (-), K (+), A1 and A2. Almond milk was given in the group treatmeant for 14 days with a dose of 4.32 ml and 8.64 ml. Fasting blood glucose measurement taken before and after treatment used Oxidase Glucose - Peroxidase Aminoantypirin (GOD PAP). Analysis of data used paired t-test, ANOVA and Post Hoc.

Results: The fasting blood glucose levels decreased significantly (p = 0.01) in the treatment group which were intervened with almond milk. A decrease in fasting blood glucose levels in a dose treatment group 1 for 116.96 ± 4.45 (p = 0:01), whereas in the group treated at a dose of 2 for 155.53 ± 3.15 (p = 0.01). There were a significant difference in decreased of the fasting blood glucose levels between the two treatment groups (p = 0.01).

Conclusion:  Giving a dose almond milk 4.32 ml and 8.64 ml for 14 days can lower the fasting blood glucose levels significantly.

Fulltext View|Download
Keywords: almond milk; fasting blood glucose; type 2 diabetes mellitus

Article Metrics:

  1. PB PERKENI. Pengelolaan dan Pencegahan Diabetes Melitus Tipe 2 di Indonesia; 2015
  2. Marcia N, Kathrin.P S, Karen L, Sara.L R. Diabetes Mellitus. In: Nutrition Therapy & Pathophysiology. 2nd Ed. 2010. p. 482–514
  3. Silva EFF, Ferreira CMM, Pinho L de. Risk Factors And Complications In Type 2 Diabetes Outpatients. Rev. Assoc. Med. Bras. 2017;63(7):621–7
  4. Veterinaria F De. Almond Milk Production and Study of Quality. Journal of Academia. 2012;2:1–8
  5. Briviba K, Gräf V, Walz E, Guamis B, Butz P. Ultra high pressure homogenization of almond milk: Physico-chemical and physiological effects. Food Chem. 2016;192:82–9
  6. Nelms M, P.Sucher K, Lacey K, Roth SL. Diabetes Mellitus. In: Nutrition Therapy & Pathophysiology. 2nd Ed. United States of America: Yolanda Cossio; 2010. p. 482–508
  7. Annadurai T, Muralidharan AR, Joseph T, Hsu MJ, Thomas PA, Geraldine P. Antihyperglycemic And Antioxidant Effects Of A Flavanone , Naringenin , In Streptozotocin – Nicotinamide-Induced Experimental Diabetic Rats. Journal of Physiology and Biochemistry. 2012;307–18
  8. Ghasemi A, Khalifi S, Jeddy S. Streptozotocin-Nicotinamide-Induced Rat Model Of Type 2 Diabetes. Acta Physiol Hung. 2014; 101(4):408-20
  9. DiaSys Diagnostic Systems GmbH. Glucose GOD FS. 2006;
  10. Antoun G, Nikpay M, Mcpherson R, Harper M. Is Type 2 Diabetes Associated with Impaired Capacity for Weight Loss ? Can J Diabetes. 2017; 42-3;
  11. Gerald Litwack. Insulin and Sugars. Acad Press. 2018;
  12. Li S-C, Liu Y-H, Liu J-F, Chang W-H, Chen C-M, Chen C-YO. Almond consumption improved glycemic control and lipid profiles in patients with type 2 diabetes mellitus. Metabolism. 2011;60(4):474–9
  13. Akubude V, Egwuonwu C, Olaniyan A, Ekiti O, Ajala OE. Almond Processing in Nigeria : Problems and Prospects. 2017;183-177
  14. Hern P, Camacho-barcia L. Nuts and Dried Fruits : An Update of Their Beneficial Effects on Type 2 Diabetes. Nutrient. 2017;1–34
  15. Post RE, Iii AGM, King DE, Simpson KN. Dietary Fiber for the Treatment of Type 2 Diabetes Mellitus : A Meta-Analysis. The Journal of the American Board of Family Medicine. 2012;25(1)
  16. Profile SEE. Beneficial Effects of High Dietary Fiber Intake in Patients with Type 2 Diabetes Mellitus. N Engl J Med 2000; 342:1392-1398
  17. Garcia-bailo B, El-sohemy A, Haddad PS, Arora P, Benzaied F. Vitamins D , C , and E in the prevention of type 2 diabetes mellitus : modulation of inflammation and oxidative stress. Biologics. 2011;7–19
  18. Rafraf M, Bazyun B, Sarabchian MA, Rafraf M, Bazyun B, Sarabchian MA, et al. Vitamin E Improves Serum Paraoxonase-1 Activity and Some Metabolic Factors in Patients with Type 2 Diabetes : No Effects on Nitrite / Nitrate Levels. J Am Coll Nutr. 2016;5724
  19. Jr EW, Glass LC. Oxidative stress in type 2 diabetes : the role of fasting and postprandial glycaemia. Int J Clin Pract. 2006;60(3):308–314. doi: 10.1111/j.1368-5031.2006.00825.x
  20. Simental-Mendía LE, Sahebkar A, Rodríguez-Morán M, Guerrero-Romero F. A systematic review and meta-analysis of randomized controlled trials on the effects of magnesium supplementation on insulin sensitivity and glucose control. Pharmacol Res. 2016;111:272–82
  21. Gommers LMM, Hoenderop JGJ, Baaij JHF De. Hypomagnesemia in Type 2 Diabetes : A Vicious Circle ? Diabetes. 2016;65:3–13
  22. Barbagallo M, Dominguez LJ. Magnesium and type 2 diabetes. World J Diabetes. 2015;6(10):1152–1157. doi: 10.4239/wjd.v6.i10.1152

Last update:

No citation recorded.

Last update: 2024-06-21 06:12:01

No citation recorded.