Chemistry Department, Faculty of Sciences and Mathematics, Diponegoro University, Indonesia
BibTex Citation Data :
@article{JKSA18551, author = {Nastiti Nastiti and Parsaoran Siahaan}, title = {Pengaruh Berat Molekul Kitosan terhadap Efisiensi Enkapsulasi BSA (Bovine Serum Albumin) Menggunakan Agen Crosslink Na-TPP}, journal = {Jurnal Kimia Sains dan Aplikasi}, volume = {18}, number = {3}, year = {2015}, keywords = {kitosan; BSA; Na-TPP; efisiensi enkapsulasi; berat molekul; energi interaksi}, abstract = {Telah dilakukan penelitian tentang pengaruh berat molekul kitosan terhadap efisiensi enkapsulasi BSA ( bovine serum albumin ) menggunakan agen crosslink Na-TPP. Penelitian ini bertujuan menentukan pengaruh berat molekul kitosan dan adanya agen crosslink Na-TPP terhadap efisiensi enkapsulasi BSA, serta memprediksi interaksi yang terjadi antara kitosan dan BSA menggunakan pemodelan molekul. Berat molekul kitosan diperkecil dengan metode hidrolisis dengan HCl 0,5N dan efisiensi enkapsulasi kitosan terhadap BSA ini ditentukan dengan pengukuran menggunakan spektrofotometer UV-Vis pada λ 278nm. Interaksi antara kitosan dan BSA dapat diketahui dengan optimasi dan penentuan energi interaksi dengan menggunakan metode ab initio dan molecular docking .. Berat molekul kitosan awal dan kitosan hasil hidrolisis HCl 0,5 N yaitu 1,666x10 5 Da dan 1,277x10 3 Da. Efisiensi enkapsulasi kitosan hasil hidrolisis lebih besar dibandingkan kitosan awal yaitu 57,111%, dengan penambahan Na-TPP menjadi 61,751%. Disimpulkan bahwa penggunaan kitosan hasil hidrolisis dengan berat molekul rendah dan adanya Na-TPP sebagai agen crosslink mampu meningkatkan kemampuan enkapsulasi kitosan. Interaksi antara kitosan dan BSA ditunjukkan dengan diperolehnya energi interaksi antara trimer kitosan dan glutamin dengan menggunakan ab initio sebesar -74,765 kJ mol -1 , sedangkan dengan molecular docking adalah -13,221 kJ mol -1 . Dengan molecular docking juga diperoleh energi interaksi antara trimer kitosan dengan glutamin pada rantai A dan B dari BSA sebesar -12,301 kJ mol -1 dan -9,665 kJ mol -1 .}, issn = {2597-9914}, pages = {104--109} doi = {10.14710/jksa.18.3.104-109}, url = {https://ejournal.undip.ac.id/index.php/ksa/article/view/18551} }
Refworks Citation Data :
Article Metrics:
Last update:
The nano mixture of ethanol extract ketumbar (Coriandrum sativum L.) seed and putri malu (Mimosa pudica L.) leaves potentially reduced blood glucose levels in hyperglycemia wistar rat
Ab-initio computational study of noncovalent interaction between peptide and alkaline metal ions on HF/6-31 G** level
Last update: 2024-11-13 04:28:22
As an article writer, the author has the right to use their articles for various purposes, including use by institutions that employ authors or institutions that provide funding for research. Author rights are granted without special permission.
Author who publishes a paper at JKSA has the broad right to use their work for teaching and scientific purposes without the need to ask permission, including: used for (i) teaching in the author's class or institution, (ii) presentation at meetings or conferences and distributing copies to participants ; (iii) training conducted by the author or author's institution; (iv) distribution to colleagues for research use; (v) use in the compilation of subsequent authors' works; (vi) inclusion in a thesis or dissertation; (vi) reuse of part of the article in another work (with citation); (vii) preparation of derivative works (with citation); (viii) voluntary posting on open websites operated by authors or author institutions for scientific purposes (follow the CC BY-SA License).
Authors and readers can copy and redistribute material in any media or format, and mix, modify, and build material for any purpose but they must provide appropriate credit (provide article citation or content), providing links to the license, and indicate if there are changes.
The authors submitting a manuscript do so on the understanding that if accepted for publication, copyright of the article shall be assigned to Jurnal Kimia Sains dan Aplikasi (JKSA). Copyright encompasses rights to reproduce and deliver the article in all form and media, including reprints, photographs, microfilms and any other similar reproductions, as well as translations.
Reproduce any part of this journal, its storage in the database or its transmission by all forms or media is permitted does not need for written permission from JKSA. However, it should be cited as an honor in academic manners
JKSA and the Chemistry Department of Diponegoro University and the Editor make every effort to ensure that there are no data, opinions, or false or misleading statements published in JKSA. However, the content of the article is the sole and exclusive responsibility of each author.
The Copyright Transfer Form can be downloaded here: [Copyright Transfer Form - Indonesian] [Copyright Transfer Form - English]. The copyright form should be signed originally and send to the Editor in the form of printed letters, scanned documents sent via email or fax.
Adi Darmawan, Ph.D (Editor in Chief)
Editor in chief of Jurnal Kimia Sains dan Aplikasi (JKSA)
Chemistry Department, Faculty of Sciences and Mathematics, Diponegoro University
Visitor: View My Stats
Jurnal Kimia Sains dan Aplikasi is indexed in:
This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.