Department of Chemistry, Faculty of Mathematics and Natural Science, IPB University, Indonesia
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@article{JKSA27149, author = {Dudi Tohir and Fitriah Sari and Irma Suparto}, title = {Cytotoxicity of the Most Active Fraction of the Seeds of Swietenia macrophylla using Human Breast Cancer MCF-7 Cells}, journal = {Jurnal Kimia Sains dan Aplikasi}, volume = {23}, number = {7}, year = {2020}, keywords = {Cytotoxicity; MCF-7 cells; Swietenia macrophylla; LC-MS}, abstract = { Ethyl acetate fraction from Swietenia macrophylla was reported to have toxicity against the larvae of Artemia salina shrimp larvae. However, there are no reports about S. macrophylla , which can inhibit human breast cancer cells MCF-7. Therefore, this study aim s to evaluate S. macrophylla extract's cytotoxicity using human breast cancer MCF-7 cells assay, followed by confirmation of its toxicity using brine shrimp lethality assay. The most active fraction obtained from the ethyl acetate extract of S. macrophylla showed 76.49% inhibition at 50 µg/mL (IC 50 =34.11 µg/mL). At the same time, the most active fraction may contain a mixture of limonoid compounds after LCMS analysis. The most active fraction obtained from ethyl acetate extract of S. macrophylla showed 76.49% }, issn = {2597-9914}, pages = {234--237} doi = {10.14710/jksa.23.7.234-237}, url = {https://ejournal.undip.ac.id/index.php/ksa/article/view/27149} }
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