Sintesis 3-(3,4-Dimetoksi Fenil)-1-Propanol Melalui Hidroborasi Metileugenol Menggunakan H3B:Dietileter

Ngadiwiyana Ngadiwiyana; Ismiyarto Ismiyarto; Ahmad Fathoni

doi:10.14710/jksa.8.1.9-16

DOI: https://doi.org/10.14710/jksa.8.1.9-16

Sintesis 3-(3,4-Dimetoksi Fenil)-1-Propanol Melalui Hidroborasi Metileugenol Menggunakan H3B:Dietileter

Ngadiwiyana Ngadiwiyana

, Ismiyarto Ismiyarto

, Ahmad Fathoni

Chemistry Department, Faculty of Sciences and Mathematics, Diponegoro University, Indonesia

Published: 1 Apr 2005.

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Abstract

Penelitian ini merupakan usaha untuk meningkatkan nilai guna dari minyak daun cengkeh dengan memanfaatkan kandungan utamanya yaitu eugenol. Eugenol dapat diubah menjadi metileugenol lalu dikonversi menjadi 3-(3,4-dimetoksi fenil)-1-propanol melalui reaksi hidroborasi dengan menggunakan reagen H₃B:dietileter. Kemudian, dioksidasi menggunakan hidrogen peroksida yang diikuti dengan hidrolisis dalam suasana basa untuk memperoleh alkohol. Produk sintesis dianalisis menggunakan spektrometer FTIR dan GC-MS. Data spektra FTIR memperlihatkan serapan kuat oleh gugus hidroksil pada bilangan gelombang 3448,5 cm^-1. Hal ini menunjukkan bahwa senyawa 3-(3,4-dimetoksifenil)-1-propanol telah terbentuk. Hasil ini diperkuat oleh pola fragmentasi senyawa pada data MS yang menunjukkan adanya puncak dasar dengan m/z = 151 dan ion molekul dengan m/z = 196 yang merupakan berat molekul dari senyawa 3-(3,4-dimetoksi fenil)-1-propanol. Produk sintesis yang diperoleh memiliki rendemen mencapai 81,29%. Selanjutnya, senyawa ini digunakan sebagai senyawa antara dalam sintesis turunan antibiotik C-9154

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Keywords: Metileugenol; Hidroborasi; Borana

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Section: Research Articles

Language : ID

In Vol 8, No 1 (2005): Volume 8 Issue 1 Year 2005

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Last update:

One pot reaction to synthesize allyl etherified eugenol from clove oil
N gadiwiyana, Ismiyarto, Gunawan, Purbowatiningrum Ria Sarjono, Nor Basid Adiwibawa Prasetya, Tutuk Djoko Kusworo, Heru Susanto. IOP Conference Series: Materials Science and Engineering, 509 , 2019. doi: 10.1088/1757-899X/509/1/012098

Last update: 2024-11-20 04:09:25

One pot reaction to synthesize allyl etherified eugenol from clove oil
N gadiwiyana, Ismiyarto, Gunawan, Purbowatiningrum Ria Sarjono, Nor Basid Adiwibawa Prasetya, Tutuk Djoko Kusworo, Heru Susanto. IOP Conference Series: Materials Science and Engineering, 509 , 2019. doi: 10.1088/1757-899X/509/1/012098

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