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Oliveramine: An Isolated Alkaloid from Fagraea fragrans (Tembesu) Bark

1Department of Chemistry, Faculty of Sciences, Sriwijaya University, Inderalaya 30662, Ogan Ilir, Indonesia

2Department of Parasitology, Faculty of Medicine, Sriwijaya University, Palembang, Indonesia

Received: 13 Jun 2022; Revised: 22 Jul 2022; Accepted: 9 Aug 2022; Published: 31 Aug 2022.
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This paper described the progress of phytochemical, especially alkaloids, work on Fagraea fragrans species (tembesu), Loganiaceae. A dimeric-pyridine alkaloid with molecular formula C20H20O4N2 has been successfully isolated from diethyl ether extracts from this plant’s barks. The alkaloid was explored from diethyl ether extracts using sulphuric acid (2%), then basified with ammonium hydroxide (25%) until the solution had a pH of 10.5. The later solution was extracted again with chloroform. The alkaloid residue was subjected to column chromatography and eluted with 10% acetone in chloroform. The chemical structure of the isolated dimeric-pyridine alkaloid was determined by LCMS/MS, 13C-NMR, and 1H-NMR spectroscopies. As a result, the isolated dimeric-pyridine alkaloid was closely similar to the oliveramine alkaloid, and this is also the first report about oliveramine from Fagraea fragrans (F. Fragrans).
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Keywords: Fagraea fragrans; bark; dimeric; pyridine; alkaloid

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