skip to main content

Determination of Antihistamine in Tablets Preparation by Fluorescence Quenching Method

Department of Pharmaceutical Chemistry,Faculty of Pharmacy, Universitas Muhammadiyah Purwokerto, Purwokerto, 53182, Indonesia

Received: 11 Aug 2021; Revised: 3 Feb 2022; Accepted: 8 Feb 2022; Published: 31 Aug 2022.
Open Access Copyright 2022 Jurnal Kimia Sains dan Aplikasi under http://creativecommons.org/licenses/by-sa/4.0.

Citation Format:
Cover Image
Abstract
The fluorescence properties of complexes of dexchlorpheniramine maleate (DXC) and erythrosine B (ERB) under buffer conditions have been observed through experiments. After the excitation was maintained at 504 nm, the emission wavelength was measured at 556 nm. The outcome demonstrated that the amount of DXC added to the mixture causes the fluorescence of erythrosine to be correspondingly quenched. This system functions best at a pH of 3.6. The research demonstrates the potential of ERB as a complexing agent for DXC quantitative analysis through complex ion formation.
Fulltext View|Download
Keywords: Fluorescence; spectrophotometric; quenching; dexchlorpheniramine maleate; Erythrosine

Article Metrics:

  1. Sally Usdin Yasuda, Peter Zannikos, Andrea E. Young, Karen M. Fried, Irving W. Wainer, Raymond L. Woosley, The roles of CYP2D6 and stereoselectivity in the clinical pharmacokinetics of chlorpheniramine, British Journal of Clinical Pharmacology, 53, 5, (2002), 519-525 https://doi.org/10.1046/j.1365-2125.2002.01578.x
  2. Jørgen Kirkegaard, Claus Secher, Niels Mygind, Effect of the H1 Antihistamine Chlorpheniramine Maleate on Histamine‐Induced Symptoms in the Human Conjunctiva: Indirect Evidence for Nervous H1, Receptors, Allergy, 37, 3, (1982), 203-208 https://doi.org/10.1111/j.1398-9995.1982.tb01897.x
  3. Joris C. Verster, Edmund R. Volkerts, Antihistamines and driving ability: evidence from on-the-road driving studies during normal traffic, Annals of Allergy, Asthma & Immunology, 92, 3, (2004), 294-304 https://doi.org/10.1016/s1081-1206(10)61566-9
  4. Aravindaraj Joghee Raju, Gopinath Ram, Rajan Sekar, Mahesh Kumar Siddaiah, Nanjan Moola Joghee, Suresh Bhojraj, Development and application of a validated liquid chromatography-mass spectrometry method for the determination of dexchlorpheniramine maleate in human plasma, Iranian Journal of Pharmaceutical Sciences, 3, 3, (2007), 161-170
  5. Nilton S. Viana Jr, Ligia M. Moreira-Campos, Cristina D. Vianna-Soares, Derivative ultraviolet spectrophotometric determination of dexchlorpheniramine maleate in tablets in presence of coloring agents, Il Farmaco, 60, 11-12, (2005), 900-905 https://doi.org/10.1016/j.farmac.2005.08.009
  6. Kementerian Kesehatan Republik Indonesia, Farmakope Indonesia Edisi VI, Jakarta, 2020
  7. Michael E. El-Kommos, Samia M. El-Gizawy, Noha N. Atia, Noha M. Hosny, Determination of Some Non-Sedating Antihistamines by Fluorescence Quenching of Erythrosine B, Asian Journal of Biochemical and Pharmaceutical Research, 4, 4, (2014), 145-163
  8. Helena S. Soedjak, Colorimetric micromethod for protein determination with erythrosin B, Analytical Biochemistry, 220, 1, (1994), 142-148 https://doi.org/10.1006/abio.1994.1310

Last update:

No citation recorded.

Last update: 2024-12-26 15:52:53

No citation recorded.