Synthesis and Antibacterial Activity Test of Dibutyl Tin (IV) N-Ethylbenzyl Dithiocarbamate Compound Against Salmonella Thy.Atcc.14028 and Propionibacterium acnes Bacteria

Mukhlis Sanuddin; Medi Andriani; Tiara Angraini

doi:10.14710/jksa.27.7.300-306

DOI: https://doi.org/10.14710/jksa.27.7.300-306

Synthesis and Antibacterial Activity Test of Dibutyl Tin (IV) N-Ethylbenzyl Dithiocarbamate Compound Against Salmonella Thy.Atcc.14028 and Propionibacterium acnes Bacteria

Mukhlis Sanuddin

, Medi Andriani, Tiara Angraini

Sekolah Tinggi Ilmu Kesehatan Harapan Ibu, Jambi, Indonesia

Received: 6 Oct 2023; Revised: 27 May 2024; Accepted: 28 May 2024; Published: 31 Jul 2024.

BibTex Citation Data :

@article{JKSA58688,
    author = {Mukhlis Sanuddin and Medi Andriani and Tiara Angraini},
    title = {Synthesis and Antibacterial Activity Test of Dibutyl Tin (IV) N-Ethylbenzyl Dithiocarbamate Compound Against Salmonella Thy.Atcc.14028 and Propionibacterium acnes Bacteria},
    journal = {Jurnal Kimia Sains dan Aplikasi},
  volume = {27},
    number = {7},
    year = {2024},
    keywords = {Synthesis of Compounds; Dithiocarbamate; FTIR; NMR; Antibacterial},
    abstract = { The complex compound dithiocarbamate exhibits various biological activities, including anticancer, antibacterial, antifungal, and antioxidant properties. Dibutyl tin (IV) N-ethyl benzyl dithiocarbamate was synthesized to overview its structure and evaluate its antibacterial activity against  Salmonella typhimurium  ATCC 14028 and  Propionibacterium acnes . This compound was synthesized via an in situ method by adding dibutyl tin (IV) dichloride, N-ethylbenzylamine, and carbon disulfide, forming a precipitate, which was then dried to yield a white powder. This powder can also be crystallized. The compound was characterized using FTIR,  1 H NMR, and  13 C NMR spectroscopy, along with antibacterial activity testing using the disc diffusion method. The FTIR analysis revealed characteristic absorption bands at 1111.00 cm -1  (C-N), 731.02 cm -1  (C-S), 2954.95 cm -1  (C-H), 1602.85 cm -1  (C=C), 360.69 cm -1  (Sn-S), and 567.07 cm -1  (Sn-C). The  1 H NMR spectrum showed chemical shifts at 0-3.8570 ppm (δ CH 3 ), 5.0032-5.1472 ppm (δ N-CH 2 ), and 7.2780-7.3607 ppm (δ C 6 H 5 ). The  13 C NMR spectrum displayed signals at 0-34.5610 ppm (δ CH 3 ), 48.6398-56.9247 ppm (δ N-CH 2 ), 127.6651-135.7665 ppm (δ C 6 H 5 ), and 201.7568 ppm (δ CS 2 ). The antibacterial activity of dibutyl tin (IV) N-ethyl benzyl dithiocarbamate was assessed, revealing inhibition zones against  Salmonella typhi  of 6.78 mm (100 ppm), 7.36 mm (120 ppm), and 7.76 mm (140 ppm), categorizing the activity as moderate. Against  Propionibacterium acnes , inhibition zones were 1.8 mm (100 ppm), 1.88 mm (120 ppm), and 2.13 mm (140 ppm), categorizing the activity as weak. Based on these findings, it can be concluded that dibutyl tin (IV) N-ethyl benzyl dithiocarbamate can be synthesized to form an octahedral structure and exhibits antibacterial activity. However, it is not yet suitable for use as a new antibiotic. },
   issn = {2597-9914},   pages = {300--306}  doi = {10.14710/jksa.27.7.300-306},
    url = {https://ejournal.undip.ac.id/index.php/ksa/article/view/58688}
}

Citation Format:

Abstract

The complex compound dithiocarbamate exhibits various biological activities, including anticancer, antibacterial, antifungal, and antioxidant properties. Dibutyl tin (IV) N-ethyl benzyl dithiocarbamate was synthesized to overview its structure and evaluate its antibacterial activity against Salmonella typhimurium ATCC 14028 and Propionibacterium acnes. This compound was synthesized via an in situ method by adding dibutyl tin (IV) dichloride, N-ethylbenzylamine, and carbon disulfide, forming a precipitate, which was then dried to yield a white powder. This powder can also be crystallized. The compound was characterized using FTIR, ¹H NMR, and ¹³C NMR spectroscopy, along with antibacterial activity testing using the disc diffusion method. The FTIR analysis revealed characteristic absorption bands at 1111.00 cm^-1 (C-N), 731.02 cm^-1 (C-S), 2954.95 cm^-1 (C-H), 1602.85 cm^-1 (C=C), 360.69 cm^-1 (Sn-S), and 567.07 cm^-1 (Sn-C). The ¹H NMR spectrum showed chemical shifts at 0-3.8570 ppm (δ CH₃), 5.0032-5.1472 ppm (δ N-CH₂), and 7.2780-7.3607 ppm (δ C₆H₅). The ¹³C NMR spectrum displayed signals at 0-34.5610 ppm (δ CH₃), 48.6398-56.9247 ppm (δ N-CH₂), 127.6651-135.7665 ppm (δ C₆H₅), and 201.7568 ppm (δ CS₂). The antibacterial activity of dibutyl tin (IV) N-ethyl benzyl dithiocarbamate was assessed, revealing inhibition zones against Salmonella typhi of 6.78 mm (100 ppm), 7.36 mm (120 ppm), and 7.76 mm (140 ppm), categorizing the activity as moderate. Against Propionibacterium acnes, inhibition zones were 1.8 mm (100 ppm), 1.88 mm (120 ppm), and 2.13 mm (140 ppm), categorizing the activity as weak. Based on these findings, it can be concluded that dibutyl tin (IV) N-ethyl benzyl dithiocarbamate can be synthesized to form an octahedral structure and exhibits antibacterial activity. However, it is not yet suitable for use as a new antibiotic.

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Keywords: Synthesis of Compounds; Dithiocarbamate; FTIR; NMR; Antibacterial

Funding: Bandung Institute of Technology has assisted with FTIR and FTNMR tests

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Section: Research Articles

Language : EN

In Vol 27, No 7 (2024): Volume 27 Issue 7 Year 2024

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