Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Indonesia, Pondok Cina, Beji, Depok City, West Java 16424, Indonesia
BibTex Citation Data :
@article{JKSA62791, author = {Chiko Harahap and Tuti Wukirsari and Sri Handayani and Sumi Hudiyono PWS}, title = {Comparison of the Lipoamide Synthesis by Direct Amidation and via Amidation of Fatty Acid Methyl Esters}, journal = {Jurnal Kimia Sains dan Aplikasi}, volume = {27}, number = {7}, year = {2024}, keywords = {aromatic amines; direct amidation; Dean-Stark trap; esterification; lipoamide}, abstract = {In this research, the preparation of lipoamide through direct amidation of fatty acid and via amidation of fatty acid methyl ester (FAME) was compared. The reactivity of aromatic amines and cyclohexylamine for the synthesis of lipoamide was investigated in this research. The performance of saturated and unsaturated fatty acids was also compared. The synthesis of lipoamides via direct amidation was conducted under reflux using a Dean-Stark trap and silica gel as the catalyst. On the other hand, the amidation of FAME was carried out without catalysts and solvent. Both reactions were run simultaneously for 18 hours at the same temperature. The reaction was monitored using TLC, and then the product was purified using column chromatography and characterized using FTIR and 1 H NMR. The TLC data, FTIR, and 1 H NMR spectra confirmed that both reaction pathways produced the same lipoamide as the product. Both reaction pathways were compatible with aromatic and nonaromatic amines and saturated and unsaturated fatty acids. The reaction yield of lipoamide from direct amidation was around 70-80% and two-fold higher than lipoamide synthesis via amidation of FAME. Therefore, direct amidation of fatty acid was preferred for the synthesis of lipoamides compared to via amidation of FAME.}, issn = {2597-9914}, pages = {328--335} doi = {10.14710/jksa.27.7.328-335}, url = {https://ejournal.undip.ac.id/index.php/ksa/article/view/62791} }
Refworks Citation Data :
Note: This article has supplementary file(s).
Article Metrics:
Last update:
Last update: 2026-09-02 01:35:38
As an article writer, the author has the right to use their article for various purposes, including use by institutions that employ the author or institutions that provide funding for the research. These author rights are granted without special permission.
Authors who publish a paper in JKSA have broad rights to use their work for teaching and scientific purposes without the need to request permission, including: (i) teaching in the author's class or institution; (ii) presenting the work at meetings or conferences and distributing copies to participants; (iii) using the work in training conducted by the author or the author's institution; (iv) distributing copies to colleagues for research purposes; (v) using the work in the compilation of subsequent works by the author; (vi) including the work in a thesis or dissertation; (vii) reusing part of the article in another work, with appropriate citation; (viii) preparing derivative works, with appropriate citation; and (ix) voluntarily posting the work on open websites operated by the author or the author's institution for scientific purposes, in accordance with the CC BY-SA License.
Authors and readers may copy and redistribute the material in any medium or format, and may remix, transform, and build upon the material for any purpose, provided that they give appropriate credit by citing the article or its content, provide a link to the license, and indicate if changes were made.
The authors submitting a manuscript do so on the understanding that, if accepted for publication, the copyright of the article shall be assigned to Jurnal Kimia Sains dan Aplikasi (JKSA). Copyright encompasses the rights to reproduce and distribute the article in all forms and media, including reprints, photographs, microfilms, and any other similar reproductions, as well as translations.
Reproducing any part of this journal, storing it in a database, or transmitting it in any form or medium is permitted without written permission from JKSA. However, the original source must be properly cited in accordance with academic conventions.
JKSA, the Chemistry Department of Diponegoro University, and the Editor make every effort to ensure that no inaccurate, false, or misleading data, opinions, or statements are published in JKSA. However, the content of each article is the sole and exclusive responsibility of its authors.
The Copyright Transfer Form can be downloaded here: [Copyright Transfer Form - Indonesian] [Copyright Transfer Form - English]. The copyright form should bear the authors' original signatures and be sent to the Editor as a printed document, a scanned document sent via email, or by fax.
Prof. Adi Darmawan, Ph.D (Editor in Chief)
Editor in chief of Jurnal Kimia Sains dan Aplikasi (JKSA)
Chemistry Department, Faculty of Sciences and Mathematics, Diponegoro University
Visitor: View My Stats
Jurnal Kimia Sains dan Aplikasi is indexed in:
This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.
