Encapsulation Rutin with Chitosan-NATPP Using Coaservation Method

DOI: https://doi.org/10.14710/reaktor.17.4.215-220
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Article Info
Submitted: 12-01-2018
Published: 19-02-2018
Section: Research Article
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Abstract

 

This study aims to make microparticles of rutin compounds at various concentrations with NaTPP-chitosan as matrix. Encapsulation is done by coaservation method. The success of encapsulation was identified by UV-Vis spectrophotometry, Fourier Transform Infra-Red (FTIR) spectroscopy and Scanning electron microscopy (SEM). Based on UV-Vis spectrophotometry analysis, the efficiency of encapsulation (EE) and loading capacity (LC) was obtained at 62,43-94,36 and 1,73% -32,1%, at rutine concentration 0,625-11,25 mM. The success of rutin encapsulation is demonstrated by the rutin characteristics of the product seen with the presence of peaks of aromatic rings, indicating the presence of rutin compounds contained in the chitosan matrix. SEM analysis shows rough and porous surface morphology in microcapsules. The rutin release profile of the microcapsules is described as two phase processes, burst release at the initial discharge in the first 30 min followed by slow release. At the highest LC (11.25 mM concentration), it provides greater discharge rates for both synthetic fluid simulations 77.53 ± 3.59% and 78.76 ± 4.00% after 3h of discharge. The controlled release data showed high discharge rates at acidic pH than alkaline pH.

 

Keywords: Rutin, encapsulation, citosan, coaservation

  1. Bambang Cahyono  Scholar
    Laboratorium Kimia Organik, Departemen Kimia, Fakultas Sains dan Matematika, Universitas Diponegoro Jl. Prof. Sudharto SH, Tembalang, Semarang 50275 (Telp/fax 024-76480824), Indonesia
    Chemistry
  2. Meiny Suzery 
    Laboratorium Kimia Organik, Departemen Kimia, Fakultas Sains dan Matematika, Universitas Diponegoro Jl. Prof. Sudharto SH, Tembalang, Semarang 50275 (Telp/fax 024-76480824), Indonesia
  3. H Hadiyanto 
    Teknik Kimia, Fakultas Teknik, Universitas Diponegoro Jl. Prof. Sudharto SH, Tembalang, Semarang 50275
  4. Sestri Bela Pratiwi 
    Laboratorium Kimia Organik, Departemen Kimia, Fakultas Sains dan Matematika, Universitas Diponegoro Jl. Prof. Sudharto SH, Tembalang, Semarang 50275 (Telp/fax 024-76480824)