Perbandingan Respon Hemodinamik 3 Menit dan 5 Menit Setelah Pemberian Fentanyl 2 mcg/kgbb iv saat Intubasi di RSUD DR Saiful Anwar Malang

*Zakiyah Ainun -  Bagian Anestesi dan Terapi Intensif Fakultas Kedokteran Universitas Brawijaya/ RSUP Dr. Saiful Anwar Malang, Indonesia
Djudjuk Rahmat Basuki -  Bagian Anestesi dan Terapi Intensif Fakultas Kedokteran Universitas Brawijaya/ RSUP Dr. Saiful Anwar Malang, Indonesia
Isngadi Isngadi -  Bagian Anestesi dan Terapi Intensif Fakultas Kedokteran Universitas Brawijaya/ RSUP Dr. Saiful Anwar Malang, Indonesia
Published: 1 Mar 2016.
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Section: Penelitian
Language: ID
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Abstract

Pendahuluan : upaya dalam mengurangi respon hemodinamik akibat laringoskopi intubasi dapat dengan non farmakologi maupun farmakologi salah satunya dengan fentanyl. Usaha tersebut dapat menurunkan morbiditas dan mortalitas sehingga memberikan output yang baik.

Tujuan: untuk mengetahui apakah waktu 5 menit setelah injeksi fentanyl merupakan waktu yang tepat dalam melakukan tindakan laringoskopi intubasi dibandingkan dengan 3 menit setalah injeksi fentanyl.

Metode : 43 pasien dengan status fisik ASA 1 dan II dilakukan pembiusan umum dengan pemasangan pipa endotrakea,di pilih secara tersamar acak tunggal. Sample penelitian dibagi menjadi dua kelompok yaitu kelompok I dengan 3 menit setelah pemberian fentanyl 2 mcg/kgbb dan kelompok II 5 menit setelah pemberian fentanyl 2 mcg/kgbb. Pasien diinduksi dengan propofol 2 mg/kgbb, difasilitasi dengan rocuronium 0.6 mg/kgbb. Kondisi respon hemodinamik dinilai sebelum induksi dan satu menit setelah laringoskopi intubasi, kemudian dibandingkan apakah waktu kelompok II lebih rendah daripada kelompok I. Data yang didapat akan diolah dengan SPSS 20.0. karakteristik akan diuji normalitas dengan Shapiro-wilk dan homogenitas dengan levene test. Perbandingan respon hemodinamik dua kelompok di uji dengan uji t sampel tidak berpasangan dengan tingkat kemaknaan p<0.05.

Hasil : terdapat perbedaan bermakna pada kedua kelompok pada variabel sistolik (pada kelompok I rerata 9.95±20.72, kelompok II -4.04 ±19.08 dengan p 0.026), diastolik (reratakelompok 1 6.90±13.78 dan kelompok II -3.69n±11.76 dengan p 0.010), dan tekanan arteri rerata (rerata kelompok I 8.70 ±16.19 dan kelompok II rerata -4.91±14.04 dengan p 0.05). sedangkan untuk variabel denyut nadi tidak bermakna secara statistic p 0.082.

Simpulan : tekanan darah akibat laringoskopi intubasi dilakukan setelah 5 menit injeksi fentanyl lebih rendah daripada 3 menit setelah injeksi fentanyl dan denyut nadi tidak didapatkan perbedaan antara kelompok 5 menit injeksi fentanyl dengan 3 menit setelah injeksi fentanyl pada pasien yang dilakukan anestesi umum.

Keywords
laringoskopi; intubasi; hemodinamik; fentanyl

Article Metrics:

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