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Perbandingan Respon Hemodinamik 3 Menit dan 5 Menit Setelah Pemberian Fentanyl 2 mcg/kgbb iv saat Intubasi di RSUD DR Saiful Anwar Malang

1Bagian Anestesi dan Terapi Intensif Fakultas Kedokteran Universitas Brawijaya/ RSUP Dr. Saiful, Indonesia

2Anwar, Indonesia

3Malang, Indonesia

Published: 1 Mar 2016.
Open Access Copyright 2016 JAI (Jurnal Anestesiologi Indonesia)

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Abstract

Pendahuluan : upaya dalam mengurangi respon hemodinamik akibat laringoskopi intubasi dapat dengan non farmakologi maupun farmakologi salah satunya dengan fentanyl. Usaha tersebut dapat menurunkan morbiditas dan mortalitas sehingga memberikan output yang baik.

Tujuan: untuk mengetahui apakah waktu 5 menit setelah injeksi fentanyl merupakan waktu yang tepat dalam melakukan tindakan laringoskopi intubasi dibandingkan dengan 3 menit setalah injeksi fentanyl.

Metode : 43 pasien dengan status fisik ASA 1 dan II dilakukan pembiusan umum dengan pemasangan pipa endotrakea,di pilih secara tersamar acak tunggal. Sample penelitian dibagi menjadi dua kelompok yaitu kelompok I dengan 3 menit setelah pemberian fentanyl 2 mcg/kgbb dan kelompok II 5 menit setelah pemberian fentanyl 2 mcg/kgbb. Pasien diinduksi dengan propofol 2 mg/kgbb, difasilitasi dengan rocuronium 0.6 mg/kgbb. Kondisi respon hemodinamik dinilai sebelum induksi dan satu menit setelah laringoskopi intubasi, kemudian dibandingkan apakah waktu kelompok II lebih rendah daripada kelompok I. Data yang didapat akan diolah dengan SPSS 20.0. karakteristik akan diuji normalitas dengan Shapiro-wilk dan homogenitas dengan levene test. Perbandingan respon hemodinamik dua kelompok di uji dengan uji t sampel tidak berpasangan dengan tingkat kemaknaan p<0.05.

Hasil : terdapat perbedaan bermakna pada kedua kelompok pada variabel sistolik (pada kelompok I rerata 9.95±20.72, kelompok II -4.04 ±19.08 dengan p 0.026), diastolik (reratakelompok 1 6.90±13.78 dan kelompok II -3.69n±11.76 dengan p 0.010), dan tekanan arteri rerata (rerata kelompok I 8.70 ±16.19 dan kelompok II rerata -4.91±14.04 dengan p 0.05). sedangkan untuk variabel denyut nadi tidak bermakna secara statistic p 0.082.

Simpulan : tekanan darah akibat laringoskopi intubasi dilakukan setelah 5 menit injeksi fentanyl lebih rendah daripada 3 menit setelah injeksi fentanyl dan denyut nadi tidak didapatkan perbedaan antara kelompok 5 menit injeksi fentanyl dengan 3 menit setelah injeksi fentanyl pada pasien yang dilakukan anestesi umum.

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Keywords: laringoskopi; intubasi; hemodinamik; fentanyl

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  1. Morgan GE, Mikhail MS, and Murray MJ, 2013, Clinical Anesthesiology, 5th edition, McGraw-Hill, Singapore
  2. Brendan T, et all, 2011, Principles Of Airway Management, 4th edition, Springer, New York
  3. Hosalli V, et all, 2014, Doses of Fentanyl on Cardiovascular Responses to Laryngoscopy and Tracheal Intubation, Journal of Clinical and Diagnostic Research, Vol 8 (9): GC01-GC03
  4. Gurulingappa, 2012, Attenuation of Cardiovascular responses to Direct Laryngoscopy and Intubation-A Comparative Study Between iv Bolus Fentanyl, Lignocaine and Placebo (NS), Journal of Clinical and Diagnostic Research, 6 (10): 1749-1752
  5. Vijayalakshmi et all, 2014, Attenuation of Hemodynamic Response to Laryngoscopy and Endotracheal Intubation with Pre Induction IV Fentanyl Versus Combination of Fentanyl and Sublingual Nitroglycerin Spray, Med Arh 2014 68(5): 339-344
  6. Malde A, Sarode V, Attenuation of The Hemodynamic Response To Endotracheal Intubation: Fentanyl Versus Lignocaine, The Internet Journal of Anesthesiology, Volume 12 (1)
  7. Safavi M, Honarmand A, Azari N, 2011, Attenuation Of The Pressor Response to Tracheal Intubatiob in Severe Preaclampsia: Relative Efficacies of Nitroglycerine Infusion, Sublingual Nifedipine, and Intravenous Hydralazine, Anesth Pain, Vol :192): 81-89
  8. Stoelting RK, and Hiller SC, 2006, Pharmacology and Physiology in Anesthetic Practice, 4th ed, Philadelphia, Lippincot Williams & Wilkins
  9. Stoelting RK, and Miller RD, 2007, Basic of Anesthesia, 5th edition, Elsivier, Philadelphia
  10. Evans, 2014, Blunting The Intubation Response: Fact or Fiction, Discipline of Anaesthetics, University of Kwazulu Natal
  11. Stanley T, 2014, The Fentanyl Story, American Pain Society, The Journal of Pain, Vol 15 No 12 www.jpain.org
  12. Collin et all, 1999, Fundamentals of Anesthesia, The Association of Anaesthetists of Great Britain and Ireland, London
  13. Gupta A, Singh N, 2013, Pharmacology in Anesthesia Practice, Oxford University Press
  14. Andrea M et all,2008, Opioid Pharmacology, Pain Physician, University of Florida, www.painphysicanjournal.com
  15. Linda W, 2004, Comparison of Fentanyl with Morphine, Pharmacy and Therapeutic Commite and The Departement of Theraphy, USA
  16. Bharat C et all, 2013, Comparative Study of Two Different doses of Fentanyl Citrate 2 mcg/kg and 4 mcg/kg intravena in attenuation of hemodynamic respon during intubation, Journal of Medical Sciences, Vol 2: 2
  17. Iyer V, Russel, 1988, Induction Using Fentanyl to Suppress The Intubation Response in The Cardiac Patient: what is the optimal dose, Anesth Intensive Care, Vol. 16(4) 411-417
  18. Adachi, et all, 2002, Fentanyl Attenuates The Hemodynamic Response To Endotracheal Intubation More Than The Respons to Laryngoscopy, Anesth Analg 95(1)233-237
  19. Miller RD, 2010, Miller’s Anesthesia, 7th edition, San Fransisco, Churchill Livingstone
  20. Guntur MT, IG Ngurah, Sri Rahardjo, 2014, Optimal time of administration of fentanyl in reducing hemodynamic response in endotracheal intubation, J Med, Volume 46, No. 2: 78 – 87
  21. Barash PG, 2009, Clinical Anesthesia, 6th edition, Philadelphia, Lippincot Williams & Wilkins
  22. Brandt, Pokar, Schutte, 1983, 110 Years of Intubation Anesthesia. William MAcewen, a Pioneer of Endotracheal Intubation, 1983, Anaesthesist 32(5) 200-204
  23. Simmon S, Schleich, 2002, Airway regional anesthesia for awake fiberoptic intubation. Regional anesthesia and pain medicine
  24. Montazeri K, et all., 2011, Attenuation of the pressor response to direct laryngoscopy and tracheal intubation: oral clonidine vs oral gabapentin premedication. Journal of research in medical sciences: the official journal of Isfahan university of medical sciences
  25. Hassan, HG et all., 1991, Hemodynamic and catecholamine responses to laryngoscopy with vs without endotracheal intubation. Acta anaesthesiologica scandinavica, 35(5), 442-447
  26. Henderson J, 2005, Tracheal intubation of adult patient. In: Caldent F, Pearce A. Core topics in airway management. New York: Cambridge university press, P. 69-80
  27. Shribman AJ, Smith G, Achola KJ, 1987, Cardiovascular and Cathecolamine Responses to Laryngoscopi with and without Tracheal Intubation, Br J Anaesth, 59(3):295-9
  28. Kanci M, et all, 2011, Haemodynamic Response to Endotracheal Intubation in Coronary Artery Disease: Direct versus video Laryngoscopy, Indian Journal of Anesthesia Vol 55: 3
  29. Katzung BG, Trevor AJ, and Masters, SB, 2008, Pharmacology, 8th Edition, McGraw-Hill, Singapore
  30. seong-hoon, kim, dong-chan, han, young-jin, song, he-sun, 1998, Small-Dose Fentanyl: Optimal Time of Injection for Blunting the Circulatory Responses to Tracheal Intubation. Anesth. Analg
  31. Kautto, 1982, Attenuation of the Circulatory Response to Laryngoscopy and Intubation by Fentanyl, Acta Anaesthesiol Scand, 26 (3): 217-21

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