DOI: https://doi.org/10.14710/jai.v10i1.20718

Tatalaksana Pasien Sepsis dengan Sindroma Cushing Iatrogenik Eksogen

1SMF Anestesi dan Perawatan Intensif Pascabedah/ , Indonesia

2Rumah Sakit Pusat Jantung Nasional dan Pembuluh Darah Harapan Kita; Jakarta, Indonesia

3Departemen Anestesi dan Terapi Intensif; Fakultas Kedokteran; Universitas Indonesia/ Rumah Sakit Umum Pusat Nasional Cipto Mangunkusumo; Jakarta, Indonesia

Published: 1 Mar 2018.
Open Access Copyright 2018 JAI (Jurnal Anestesiologi Indonesia)

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Abstract

Sepsis adalah disfungsi organ mengancam nyawa akibat ketidakseimbangan respon tubuh terhadap infeksi. Kerentanan terhadap infeksi berat pada penderita penyakit autoimun maupun immunokompromais disebabkan konsumsi obat dan terapi yang dijalani. Pemberian atau penggunaan kortikosteroid dosis tinggi dan lama seperti hiperkortisolisme atau sindrom Cushing meningkatkan kerentanan terhadap infeksi Pasien imunokompromis berisiko tinggi mengalami infeksi patogen serta infeksi oportunistik oleh mikroorganisme virulen. Infeksi merupakan faktor predisposisi terjadinya peningkatan respon kompromi sistemik tubuh dalam kondisi sepsis dan syok sepsis. Kasus ini melaporkan seorang pasien berusia 24 tahun dengan sepsis akibat pneumonia yang diperberat oleh sindroma Cushing iatrogenic akibat steroid yang dikonsumsi dalam waktu lama, menyebabkan sulitnya perawatan serta prognosis yang buruk.

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Keywords: Sepsis; immunokompromais; sindroma cushing iatrogenis

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Section: Case Reports
Language : ID
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  1. Singer M, Deutschman CS, et al: The third international consensus definitions for sepsis and septic shock (sepsis-3). JAMA 2016; 315(8):801-10
  2. Vincent JL, Abraham E. The last 100 years of sepsis. Am J Respir Crit Care Med 2006;173:256-63
  3. Esper AM, Martin GS. Extending international sepsis epidemiology: the impact of organ dysfunction. Crit Care 2009;13:120
  4. Kalil CA, MS Opal. Sepsis in the Severely Immunocompromised Patient. Curr Infect Dis Rep, 2015: 1-10
  5. Silva E, Passos Rda H, Ferri MB, de Figueiredo LF. Sepsis: from bench to bedside. Clinics (Sao Paulo) 2008;63:109-20
  6. Remick DG. Pathophysiology of sepsis. Am J Pathol 2007;170:1435-44
  7. Rudiger A, Stotz M, Singer M. Cellular processes in sepsis. Swiss Med Wkly 2008;138:629-34
  8. Samuels, M.H, Cushing’s Syndrome. In: Mc Dermott MT (ed). Endocrine Secrets. 2nded. Hanley & Belfus Inc. Colorado, 1998 :139-46
  9. Sarlis, N.J., Chanock, S.J., Nieman, L.K., Cortisolemic Indices Predict Severe Infections in Cushing Syndrome due to Ectopic Production of Adrenocorticotropin. Journal of Clinical and Metabolism, 2000 : 85(1); 42-7
  10. Chiavone PA, Sens YAS. Evaluation of APACHE II system among intensive care patients at hospital. Sao Paulo Med J. 2003;121:53-7
  11. Gupta R, Arora VK. Performance evaluation of APACHE II score for an Indian patient with respiratory problems. Indian J Med Res. 2004;119:273-82
  12. Ferreira FL, Bota DP, Bross A, Vincent JL. Serial evaluation of the SOFA score to predict outcome in critically ill patients. JAMA.2001;286:1754-58
  13. Abbas AK, Lichtman AH, Pillai SHIV. Role of Infections in Autoimmunity, In: Cellular and Molecular Immunology.Philadelphia, 2010
  14. Grover S, Kate N. Assessment scales for delirium: A review, World J Psychiatr 2012 August 22; 2(4): 58-70
  15. Musher DM; Thorner AR Community-acquired pneumonia. N Engl J Med. 2014; 371(17):1619-28
  16. Fung HB, Monteagudo-Chu MO. Community-acquired pneumonia in the elderly. Am J Geriatr Pharmacother. 2010 Feb. 8(1):47-62
  17. Mandell LA, Wunderink RG, Anzueto A, Bartlett JG, Campbell GD, Dean NC, et al. Infectious Diseases Society of America/American Thoracic Society consensus guidelines on the management of community-acquired pneumonia in adults. Clin Infect Dis. 2007 Mar 1. 44 Suppl 2:S27-72
  18. Ragnarsson O, Glad CA, Bergthorsdottir R, Almqvist EG, Ekerstad E, Widell H, et al. Body composition and bone mineral density in women with Cushing's syndrome in remission and the association with common genetic variants influencing glucocorticoid sensitivity. Eur J Endocrinol. 2015 Jan. 172 (1):1-10
  19. Vincent J, Carlet J, Opal SM, eds. The Sepsis Text. New York: Kluwer Academic Publishers, 2002
  20. Bone RC, Grodzin CJ, Balk RA. Sepsis: a new hypothesis for pathogenesis of the disease process. Chest. 1997;112:235-43
  21. Kalil CA, Opal MS. Sepsis in the Severely Immunocompromised Patient, Curr Infect Dis Rep 2015: 1-10
  22. Cardoso LTQ, Grion MC, Matsuo T. Impact of delayed admission to intensive care units on mortality of critically ill patients: a cohort study. Critical Care 2011: 2-8
  23. S S Rafael, Dora JM, Weinert LS. Invasive fungal infections in endogenous Cushing’s syndrome, Infectious Disease Reports 2010; volume 2:9-10
  24. Fritz JM1, Brielmaier BD, Dubberke ER. Micafungin for the prophylaxis and treatment of Candida infections , Expert Rev Anti Infect Therapy. 2008:153-62
  25. Neto A, Marcus J, Festic SE.Ventilatory support of patients with sepsis or septic shock in resource-limited settings, Intensive Care Med 2016 42:100–103
  26. Hsiung Lee ES, Jiann Lim DT, Taculod JM. Factors associated with reintubation in an intensive care unit:A prospective observational study. Indian J Crit Care Med 2017;21:131‑7
  27. Neyra JA,Xilong Li, PhD, Escaro, FC. Cumulative Fluid Balance and Mortality in Septic Patients with or without Acute Kidney Injury and Chronic Kidney Disease, Crit Care Med. 2016 October ; 44(10): 1891–1900

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