Efek Pemberian Midazolam atau Propofol Terhadap Lama Penggunaan Ventilator Mekanik di ICU RSUP Dr. Kariadi
Pendahuluan : Sedasi di ruang intensif dapat memperbaiki outcome perawatan dan
membuat pasien lebih nyaman, namun juga berpotensi memperpanjang durasi ventilasi
mekanik dan length of stay (LOS). Obat yang saat ini sering digunakan adalah
midazolam, namun durasi kerja midazolam dapat memanjang pada pasien dengan gagal
fungsi organ. Propofol adalah obat sedasi dengan klirens tinggi dan tanpa metabolit aktif
yang dapat digunakan untuk memperpendek durasi ventilasi mekanik dan LOS pasien.
Membandingkan durasi ventilasi mekanik dan biaya sedasi pada pasien pascabedah di
ruang intensif yang disedasi menggunakan midazolam dan propofol.
Metode : Dilakukan penelitian obser vasional dengan desain cross-sectional terhadap
30 pasien pascabedah dengan ventilator di ICU yang dibagi menjadi 2 kelompok secara
acak, masing-masing kelompok terdiri dari 15 pasien. Kelompok I mendapat midazolam
bolus 0,02-0,08 mg/kg IV, dilanjutkan infus kontinyu dosis 0,04-0,2 mg/kg/jam.
Kelompok II mendapat Propofol bolus 1,5-2,5 mg/kg IV, dilanjutkan infus kontinyu dosis
5-80 μg/kg/menit. Target skor RASS adalah -1 sampai -2, yang dipantau 1 jam
pascasedasi, dilanjutkan tiap 4 jam setelahnya. Pencatatan dilakukan terhadap durasi
ventilator mekanik, rerata skor RASS, dan biaya sedasi.
Hasil : Penelitian ini menunjukan bahwa dur asi ventilasi mekanik dan biaya sedasi
pada kelompok propofol lebih rendah daripada midazolam, namun perbedaannya tidak
bermakna dengan nilai p≤0,05.
Kesimpulan : Sedasi pasien pascabedah dengan ventilator di r uang intensif dengan
propofol lebih efektif dalam mengurangi durasi ventilasi mekanik dan biaya sedasi
daripada midazolam, namun tidak berbeda bermakna.
Article Metrics:
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