Keamanan Penggunaan Propofol Auto-Coinduction Dibandingkan Dengan Midazolam Coinduction Berdasarkan Perubahan Hemodinamik Pada Induksi Anestesi Pasien Yang Dilakukan General Anestesi

*I Nyoman Yesua -  Bagian Anestesiologi dan Terapi Intensif, Fakultas Kedokteran, Universitas Airlangga/ RSUD Dr. Soetomo Surabaya, Indonesia
Puger Rahardjo -  Bagian Anestesiologi dan Terapi Intensif, Fakultas Kedokteran, Universitas Airlangga/ RSUD Dr. Soetomo Surabaya, Indonesia
Pesta Parulian Maurid Edwar -  Bagian Anestesiologi dan Terapi Intensif, Fakultas Kedokteran, Universitas Airlangga/ RSUD Dr. Soetomo Surabaya, Indonesia
Published: 1 Mar 2019.
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Section: Penelitian
Language: ID
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In Vol 11, No 1 (2019): Jurnal Anestesiologi Indonesia
Statistics: 357 257
Abstract

Latar Belakang: Pemilihan obat anestesi untuk induksi bagi seorang ahli anestesi merupakan hal yang krusial dan didasarkan atas efek farmakodinamik terhadap sistem kardiovaskular.

Tujuan: Menganalisa apakah penggunaan propofol auto-coinduction (pre-dosing propofol) dapat digunakan sebagai alternatif midazolam sebagai obat coinduction, dilihat dari segi keamanan pasien (perubahan hemodinamik yang terjadi) dan biaya yang dikeluarkan.

Metode: Penelitian eksperimental dengan desain pre-posttest single blind group ini melibatkan 52 pasien yang menjalani operasi elektif dengan anestesi umum di Kamar Operasi Gedung Bedah Pusat Terpadu (GBPT) RSUD Dr. Soetomo Surabaya pada bulan September-Oktober 2018. Dua kelompok pasien masing-masing mendapatkan midazolam 0,03 mg/KgBB (kelompok M, n=26) dan propofol 0,4 mg/KgBB (kelompok P, n=26) 2 menit sebelum induksi dengan propofol titrasi sampai hilang kontak verbal. Dosis propofol yang digunakan, tekanan darah sebelum dan sesudah dilakukan induksi serta biaya induksi dicatat.

Hasil: Rerata Arterial Pressure (MAP) pra-induksi pada kelompok M adalah 96,35 ±11,366 mmHg dan pada kelompok P 90,54 ±7.732 mmHg, sedangkan MAP pascainduksi pada kelompok M sebesar 79.96 ±9.21mmHG dan pada kelompok P adalah 73,96 ±5,03mmHg (p=0,037). Total biaya yang digunakan pada kelompok M adalah Rp. 7.890 ±1.448.89 sedangkan pada kelompok P Rp. 7.082 ±1.403.89 (p=0.047).

Kesimpulan: Terdapat perbedaan bermakna pada perubahan MAP yang disebabkan oleh penggunaan propofol auto-coinduction bila dibandingkan dengan midazolam coinduction. Tidak terdapat perbedaan signifikan penurunan tekanan darah dan nadi, serta dosis propofol yang digunakan antara kedua kelompok. Biaya induksi pada kelompok auto-coinduction propofol secara signifikan lebih rendah.

Note: This article has supplementary file(s).

Keywords
anestesi umum; keamanan hemodinamik; midazolam co-induction; obat; propofol auto-coinduction

Article Metrics:

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