Pengaruh Pemberian Ketorolak 30 mg Intravena pada Penderita dengan Anestesi Spinal Terhadap Fungsi Pembekuan Darah : Protrombin Time, Partial Tromboplastin Time with Kaolin

Tujuan: Membuktikan bahwa pemberian ketorolak 30 mg intravena pada penderita dengan spinal anestesi menyebabkan pemanjangan fungsi koagulasi (protrombin time dan partial tromboplastin time)
Metode: Merupakan penelitian eksperimental dengan randomized post test only controlled group pada 30 penderita yang akan menjalani operasi elektif dengan anestesi spinal. Penderita secara random dibagi menjadi dua kelompok, yaitu kelompok P yang mendapat ketorolak 30 mg iv dan kelompok K yang mendapat placebo ((NaCl 0,9%). Pemeriksaan PT, PTT dilakukan menjelang operasi dan 60 menit setelah pemberian ketorolak atau placebo. Hasilnya dinilai dengan menggunakan uji statistikparametric T- test, dengan derajat kemaknaan p<0,05.
Hasil: Uji Independent T-test variable PT post tindakan dan PTTK post tindakan antara kelompok P dan kelompok K menunjukkan perbedaan yang tidak bermakna (p>0,05). Uji Paired T-test, untuk variabel PT pre tindakan dan PT post tindakan pada kelompok P menunjukkan perbedaan yang tidak bermakna (p=0,237). Untuk variable PTTK pre tindakan dan PTTK post tindakan pada kelompok P menunjukkan perbedaan bermakna (p=0,029). Uji Paired T-test, untuk variabel PT pre tindakan dan PT post tindakan pada kelompok K menunjukkan perbedaan yang tidak bermakna(p=0,062). Untuk variabel PTTK pre tindakan dan PTTK post tindakan pada kelompok K menunjukkan perbedaan tidak bermakna(p=0,160).
Kesimpulan: Pemberian dosis tunggal ketorolak 30 mg intravena pada penderita dengan anestesi spinal tidak berpengaruh terhadap fungsi koagulasi jalur ekstrinsik (PT) tapi akan memperpanjang fungsi koagulasi jalur intrinsik (PTTK) namun pemanjangan ini masih dalam batas normal atau tidak nampak secara klinis.
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