Perbandingan Waktu Pemberian Atrakurium Besylate Intravena 0,5 mg/kgbb 5 Detik dan 90 Detik Terhadap Peningkatan Nadi Saat Induksi Anestesi Umum di Rumah Sakit Saiful Anwar Malang

*Suparno Adi Santika  -  Bagian/SMF Anestesi dan Terapi Intensif, Fakultas Kedokteran, Universitas Brawijaya/ RSU dr Saiful Anwar, Indonesia
Djujuk Rahmat Basuki  -  Bagian/SMF Anestesi dan Terapi Intensif, Fakultas Kedokteran, Universitas Brawijaya/ RSU dr Saiful Anwar, Indonesia
Karmini Karmini  -  Bagian/SMF Anestesi dan Terapi Intensif, Fakultas Kedokteran, Universitas Brawijaya/ RSU dr Saiful Anwar, Indonesia
Published: 1 Mar 2015.
Open Access
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Abstract

Latar Belakang : Atracurium besylate, merupakan obat pelumpuh otot nondepolarisasi kelas bisquaternary benzylisoquinolinium yang menghasilkan beberapa efek samping selama uji klinis luas di berbagai penelitian, berupa pelepasan histamin yang dikaitkan dengan refleks takikardia, hipotensi berat dan ruam pada pengamatan klinis. Beberapa kasus reaksi anafilaksis parah dilaporkan setelah injeksi atrakurium, menyebabkan komplikasi yang mengancam jiwa. Pemberian lambat injeksi Atrakurium besylate, menurunkan manifestasi refleks peningkatan nadi. Tujuan penelitian ini adalah untuk mengetahui, perbandingan waktu pemberian Atrakurium besylate intravena dapat menurunkan tingkat kejadian peningkatan nadi saat induksi anestesi umum di RSSA Malang.

Metode : Penelitian ini merupakan uji klinis tersamar tunggal, bersifat eksperimental. Pasien dengan kriteria klinis ASA I-II sejumlah 32 orang dilakukan randomisasi sederhana menjadi 2 kelompok P dan mendapatkan perlakuan pemberian Atrakurium besylate 0,5 mg/kgBB iv dalam waktu 5 detik. Kelompok lainya dilakukan pemberian Atrakurium besylate 0,5 mg/kgBB iv dalam waktu 90 detik

Hasil : Penelitian ini didapatkan, perbedaan peningkatan nadi yang bermakna secara statistik (p < 0,05), pada saat kelompok O dan P dibandingkan pada menit ke 3 (0,005) dan ke 4 (0,004), sedangkan pada menit ke 5 (0,210) tidak didapatkan perbedaan peningkatan nadi pasien

Kesimpulan :  Disimpulkan bahwa, pemberian Atrakurium besylate intravena 0,5 mg/kgBB dalam waktu 90 detik menurunkan tingkat terjadinya peningkatan nadi daripada pemberian dalam waktu 5 detik.

Keywords: Atracurium besylate; Administration; Tachycardia

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Article Info
Section: Penelitian
Language: ID
In Vol 7, No 1 (2015): Jurnal Anestesiologi Indonesia
Statistics: 2199 725
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