Perbandingan Waktu Pemberian Atrakurium Besylate Intravena 0,5 mg/kgbb 5 Detik dan 90 Detik Terhadap Peningkatan Nadi Saat Induksi Anestesi Umum di Rumah Sakit Saiful Anwar Malang

Latar Belakang : Atracurium besylate, merupakan obat pelumpuh otot nondepolarisasi kelas bisquaternary benzylisoquinolinium yang menghasilkan beberapa efek samping selama uji klinis luas di berbagai penelitian, berupa pelepasan histamin yang dikaitkan dengan refleks takikardia, hipotensi berat dan ruam pada pengamatan klinis. Beberapa kasus reaksi anafilaksis parah dilaporkan setelah injeksi atrakurium, menyebabkan komplikasi yang mengancam jiwa. Pemberian lambat injeksi Atrakurium besylate, menurunkan manifestasi refleks peningkatan nadi. Tujuan penelitian ini adalah untuk mengetahui, perbandingan waktu pemberian Atrakurium besylate intravena dapat menurunkan tingkat kejadian peningkatan nadi saat induksi anestesi umum di RSSA Malang.
Metode : Penelitian ini merupakan uji klinis tersamar tunggal, bersifat eksperimental. Pasien dengan kriteria klinis ASA I-II sejumlah 32 orang dilakukan randomisasi sederhana menjadi 2 kelompok P dan mendapatkan perlakuan pemberian Atrakurium besylate 0,5 mg/kgBB iv dalam waktu 5 detik. Kelompok lainya dilakukan pemberian Atrakurium besylate 0,5 mg/kgBB iv dalam waktu 90 detik
Hasil : Penelitian ini didapatkan, perbedaan peningkatan nadi yang bermakna secara statistik (p < 0,05), pada saat kelompok O dan P dibandingkan pada menit ke 3 (0,005) dan ke 4 (0,004), sedangkan pada menit ke 5 (0,210) tidak didapatkan perbedaan peningkatan nadi pasien
Kesimpulan : Disimpulkan bahwa, pemberian Atrakurium besylate intravena 0,5 mg/kgBB dalam waktu 90 detik menurunkan tingkat terjadinya peningkatan nadi daripada pemberian dalam waktu 5 detik.
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