DOI: https://doi.org/10.14710/jksa.22.5.206-212

Identifikasi Senyawa Aktif Ekstrak Buah Mengkudu (Morinda citrifolia L.) dan Potensinya sebagai Antioksidan

Identification of Active Compound Extracts from Noni Fruit (Morinda citrifolia L.) and Its Potential as Antioxidants

Universitas 17 Agustus 1945 Jakarta, Indonesia

Received: 13 Jul 2019; Revised: 13 Aug 2019; Accepted: 20 Aug 2019; Published: 30 Sep 2019.
Open Access Copyright 2019 Jurnal Kimia Sains dan Aplikasi under http://creativecommons.org/licenses/by-sa/4.0.

Citation Format:
Cover Image
Abstract
Antioxidants are compounds that can inhibit oxidation reactions by binding to free radicals and highly reactive molecules. One form of reactive oxygen compounds is free radicals, these compounds are formed in the body and are triggered by various factors. Noni fruits have been used by the community as a medicine for high blood pressure, beriberi, urinating, inflammation of bile, inflammation of the intestine, dysentery, constipation, spleen pain, liver pain, diabetes and lumbago. Nevertheless, research on the identification of the active compounds of noni fruit which act as antioxidants yet. This study aims to extract and fractionation of Noni fruit, determine the antioxidant activity of Noni fruit extract, and identify the types of bioactive compounds that act as antioxidants. Noni fruit was extracted used maceration technique with 96% ethanol and then fractionated using n-hexane, chloroform and ethyl acetate solvents. Antioxidant activity from the results of noni fruit fractionation was measured by the DPPH (1.1 diphenyl-2-picrylhydrachyl) method and identification of bioactive compounds was carried out by GCMS. The results showed the greatest antioxidant activity was found in chloroform fraction with a percentage of inhibition of 78.19%. For the first time this study revealed the types of bioactive compounds from noni fruit ethyl acetate fraction which act as antioxidants are n-hexadecanoic acid, squalene, pyridin-3-carboxamide, oxime, n- (2-trifluoro methyl phenyl), and beta-sitosterol
Fulltext View|Download
Keywords: Antioxidant; Bioactive; DPPH; Noni fruits (Morinda citrifolia L)

Article Metrics:

Article Info
Section: Research Articles
Language : ID
Recent articles
Kinetics of Transesterification Reaction of Soybean Oil into Biodiesel with CaO Catalyst Antibacterial Activity of Loloh (Traditional Balinese Medicine) Decoction Water and Squeeze Water of betel Leaf against Bacteria Streptococcus pyogenes causes of sore throat Optimization of Cd(II) adsorption condition by glycine-modified silica-based adsorbent using central composite design More recent articles
Most cited articles
Total Hyptolide of Indonesian Hyptis pectinata extracts in a various solvent using HPLC and UV-Vis spectroscopy and their toxicities Pengaruh Perlakuan Asam dan Kalium Permanganat terhadap Karakter Zeolit Tasik Sintesis 3-(3,4-Dimetoksi Fenil)-1-Propanol Melalui Hidroborasi Metileugenol Menggunakan H3B:Dietileter Aktivitas Antioksidan dan Antibakteri Produk Fermentasi Susu Kedelai dan Whey Tahu menggunakan Bakteri Asam Laktat Komersial Sintesis Lempung Terpilar Polikation Alumunium Sebagai Adsorben Indigo Karmina More cited articles
  1. Roja Rahimi, Shekoufeh Nikfar, Bagher Larijani, Mohammad Abdollahi, A review on the role of antioxidants in the management of diabetes and its complications, Biomedicine & Pharmacotherapy, 59, 7, (2005) 365-373 https://doi.org/10.1016/j.biopha.2005.07.002
  2. Małgorzata Nita, Andrzej Grzybowski, The Role of the Reactive Oxygen Species and Oxidative Stress in the Pathomechanism of the Age-Related Ocular Diseases and Other Pathologies of the Anterior and Posterior Eye Segments in Adults, Oxidative Medicine and Cellular Longevity, 2016, (2016) 23 https://doi.org/10.1155/2016/3164734
  3. Yulong Zhang, Ping Hu, Lijiao Lou, Jianlong Zhan, Min Fan, Dan Li, Qianwei Liao, Antioxidant Activities of Lactic Acid Bacteria for Quality Improvement of Fermented Sausage, Journal of Food Science, 82, 12, (2017) 2960-2967 https://doi.org/10.1111/1750-3841.13975
  4. Dixit Rajiv Ramesh, Sanjay C Swami, Total antioxidant capacity of some common seeds and effect of sprouting and its health benefits, International Journal of Chemical Studies, 4, 2, (2016) 25-27
  5. S. Kapila, P. R. Sinha, Antioxidative and hypocholesterolemic effect of Lactobacillus casei ssp casei (biodefensive properties of lactobacilli), Indian journal of medical sciences, 60, 9, (2006) 361-370
  6. Yiyun Liu, Haiming Chen, Wenxue Chen, Quipping Zhong, Guanfei Zhang, Weijun Chen, Beneficial Effects of Tomato Juice Fermented by Lactobacillus Plantarum and Lactobacillus Casei: Antioxidation, Antimicrobial Effect, and Volatile Profiles, Molecules, 23, 9, (2018) 2366 https://doi.org/10.3390/molecules23092366
  7. Abdul Rohman, Sugeng Riyanto, Nurul Khusna Hidayati, Aktivitas Antioksidan, Kandungan Fenolik Total, dan Flavonoid Total Daun Mengkudu (Morinda citrifolia L), agriTECH, 27, 4, (2016) 147-151 https://doi.org/10.22146/agritech.9849
  8. Sogandi Sogandi, Uji Aktivitas Antibakteri Ekstrak Etanol 96% Daun Rambai (Sonneratia Caseolaris,(L.) Engl) Terhadap Pertumbuhan Bakteri Escherichia Coli, Indonesia Natural Research Pharmaceutical Journal, 2, 1, (2017) 73-80
  9. Anjar Purba Asmara, Uji Fitokimia Senyawa Metabolit Sekunder dalam Ekstrak Metanol Bunga Turi Merah (Sesbania grandiflora L. Pers), Al Kimia, 5, 1, (2017) 48-59
  10. Direktorat Pengawasan Obat Tradisional - Departemen Kesehatan Republik Indonesia, Parameter Standar Umum Ekstrak Tumbuhan Obat, in, 2000
  11. Zeta Kuntari, Sumpono Sumpono, Nurhamidah Nurhamidah, Aktivitas Antioksidan Metabolit Sekunder Bakteri Endofit Akar Tanaman Moringa oleifera L (Kelor), ALOTROP Jurnal Pendidikan dan Ilmu Kimia, 1, 2, (2017) 80-84
  12. Domnic Maxwell Colvin, A Review on Comparison of the Extraction Methods Used in Licorice Root: Their Principle, Strength and Limitation, Medicinal & Aromatic Plants, 7, 6, (2018) 1-4 https://doi.org/10.4172/2167-0412.1000323
  13. Badan Pengawas Obat dan Makanan Republik Indonesia, Kriteria dan Tata Laksana Pendaftaran Obat Tradisional, Obat Herbal Terstandar dan Fitofarmaka, in: B.P.O.d.M.R. Indonesia (Ed.), Jakarta, 2005
  14. Louis J. Kirschenbaum, Ben Ruekberg, A Correlation of the Solubility of Water in Hydrocarbons as a Function of Temperature Based on the Corresponding Vapor Pressure of Pure Water, Chemical Sciences Journal, 2013, CSJ-101, (2013)
  15. Divya Gupta, Mukesh Kumar, Evaluation of in vitro antimicrobial potential and GC–MS analysis of Camellia sinensis and Terminalia arjuna, Biotechnology Reports, 13, (2017) 19-25 https://doi.org/10.1016/j.btre.2016.11.002
  16. Rudiyansyah, Chia Lang Lang, Gusrizal Gusrizal, Andi Hairil Alimuddin, Senyawa Antrakuinon yang Bersifat Antioksidan dari Kayu Akar Tumbuhan Mengkudu (Morinda citrifolia), Bulletin of The Indonesian Society of Natural Products Chemistry, 12, (2012) 9-13
  17. J Helan Chandra, Harini Gunasekaran, Screening of phytochemical, antimicrobial and antioxidant activity of Glycyrrhiz glabra root extract, Journal of Environmental Biology, 38, 1, (2017) 161-165
  18. Irina I. Koleva, Teris A. van Beek, Jozef P. H. Linssen, Aede de Groot, Lyuba N. Evstatieva, Screening of Plant Extracts for Antioxidant Activity: a Comparative Study on Three Testing Methods, Phytochemical Analysis, 13, 1, (2002) 8-17 https://doi.org/10.1002/pca.611
  19. Gloria Sindora, Andi Hairil Allimudin, Harlia, Identifikasi Golongan Senyawa Antraquinon pada Fraksi Kloroform Akar Kayu Mengkudu (Morinda citrifolia, L), Jurnal Kimia Khatulistiwa, 6, 1, (2017) 37-41
  20. Zhong-hui Pu, Yu-qun Zhang, Zhong-qiong Yin, Jiao Xu, Ren-yong Jia, Yang Lu, Fan Yang, Antibacterial Activity of 9-Octadecanoic Acid-Hexadecanoic Acid-Tetrahydrofuran-3,4-Diyl Ester from Neem Oil, Agricultural Sciences in China, 9, 8, (2010) 1236-1240 https://doi.org/10.1016/S1671-2927(09)60212-1
  21. Shah Ankita, Singh Tribhuwan, Vijayvergia Rekha, GC-MS Analysis of Bioactive Phytoconstituents from Rumex vesicarius L., International Research Journal of Pharmacy, 6, 4, (2015) 269-272
  22. D Sheela, F Uthayakumari, GC-MS analysis of bioactive constituents from coastal sand dune taxon-Sesuvium portulacastrum (L.), Bioscience discovery, 4, 1, (2013) 47-53
  23. Zih-Rou Huang, Yin-Ku Lin, Jia-You Fang, Biological and Pharmacological Activities of Squalene and Related Compounds: Potential Uses in Cosmetic Dermatology, Molecules, 14, 1, (2009) 540-554 https://doi.org/10.3390/molecules14010540
  24. Rohan V. Tikekar, Richard D. Ludescher, Mukund V. Karwe, Processing Stability of Squalene in Amaranth and Antioxidant Potential of Amaranth Extract, Journal of Agricultural and Food Chemistry, 56, 22, (2008) 10675-10678 https://doi.org/10.1021/jf801729m
  25. Keshav Mahajan Ghanashyam, Yashwant Mahajan Arun, Totaram Mahajan Raghunath, Efficacy of Aphrodisiac Plants towards Improvement in Semen Quality and Motility in Infertile Males, Journal of Complementary and Integrative Medicine, 9, 1, (2012) 1-12 https://doi.org/10.1515/1553-3840.1520
  26. Patil Manisha, Patil Chandrashekhar, Mahajan Raghunath, Phytochemical Investigation and Validation of Antioxidant Potential of β-Sitosterol from Tubers of Eulophia herbacea and Eulophia ochreata, International Journal of Pharmacognosy and Phytochemical Research, 10, 8, (2018) 309-316

Last update:

  1. Antidiabetes effect of Noni Fruit (Morinda citrifolia L.) on mice with Oral Glucose Tolerance Method and Streptozotocin Induction Method

    Nikeherpianti Lolok, Sahidin I., Sri Adi Sumiwi, Ahmad Muhtadi. Research Journal of Pharmacy and Technology, 2021. doi: 10.52711/0974-360X.2021.00883

Last update: 2024-11-21 18:52:32

No citation recorded.