skip to main content

The Effectiveness of Adding Red Fruit Oil (Pandanus conoideus Lamk.) into Ethanol Extract of Temulawak rhizome (Curcuma xanthorrhiza Roxb.) as Antioxidant

Department of Chemistry, Faculty of Science and Informatics, Jenderal Achmad Yani University, Indonesia

Received: 6 Dec 2019; Revised: 20 Nov 2020; Accepted: 29 Nov 2020; Published: 30 Nov 2020.
Open Access Copyright 2020 Jurnal Kimia Sains dan Aplikasi under http://creativecommons.org/licenses/by-sa/4.0.

Citation Format:
Cover Image
Abstract
Curcuma xanthorrhiza Roxb (temulawak) is a native Indonesian plant; ethnobotanically, it can facilitate breast milk, body fresheners, stomach lozenges, and seizure medications. Temulawak contains essential oils, curcuminoids, and xanthorrhizol. Curcuminoids and xanthorrhizol have potential as antioxidants. Antioxidants in the body are useful for preventing oxidation reactions caused by free radicals, both from body metabolism and external factors. Curcuminoids are difficult to dissolve in water and have a very low bioavailability. Combining curcuminoids with oil can increase the absorption of curcuminoids into the systemic system. The low solubility and bioavailability can be overcome by combining temulawak rhizome extract and red fruit oil. Pandanus conoideus Lamk (red fruit), ethnobotanically, effectively prevents blindness, intestinal worms, skin diseases, and increasing stamina. Red fruit contains vitamin C, vitamin E, flavonoids, and β-carotene, potentially as antioxidants. Each sample of Curcuma and red fruit, as well as a mixture of Curcuma and red fruit samples, were tested for their antioxidant activity using the DPPH method (1,1-diphenyl-2-picrylhydrazyl). The ethanol extract of temulawak rhizome has intense antioxidant activity because it has an IC50 of 55.21 ppm. Red fruit oil has feeble antioxidant activity because it has an IC50 of 2604.77 ppm. The 1: 1 ratio between red fruit oil and the ethanol extract of temulawak rhizome has weak antioxidant activity because it has an IC50 of only 1568.24 ppm. Meanwhile, the 1:10 ratio of red fruit oil and ethanol extract of temulawak rhizome has robust antioxidant activity because it has an IC50 of 19.85 ppm. It is concluded that the addition of oil to the ethanol extract of Curcuma can increase antioxidant activity.
Fulltext View|Download
Keywords: red fruit; temulawak; antioxidant; DPPH
Funding: Universitas Jenderal Achmad Yani

Article Metrics:

  1. I Made Dira Swantara, I Made Oka Adi Parwata, Kajian senyawa antioksidan pada rumput laut dari pantai sekitar bali, in: The excellence research Universitas Udayana 2011 Universitas Udayana, Badung, 2011
  2. Asri Werdhasari, Peran antioksidan bagi kesehatan, Jurnal Biotek Medisiana Indonesia, 3, 2, (2014), 59-68
  3. S. Sidik, M.W. Moelyono, A. Mutadi, Temulawak, Universitas Padjadjaran, Bandung, 1992
  4. Benjawan Pitasawat, Wej Choochote, Benjawan Tuetun, Pongsri Tippawangkosol, Duangta Kanjanapothi, Atchariya Jitpakdi, Duangrat Riyong, Repellency of aromatic turmeric Curcuma aromatica under laboratory and field conditions, Journal of Vector Ecology, 28, 2, (2003), 234-240
  5. Jae-Kwan Hwang, Antibacterial composition having xanthorrizol, US6696404B1, US Patents, US, 2004
  6. G. K. Jayaprakasha, L. Jaganmohan Rao, K. K. Sakariah, Antioxidant activities of curcumin, demethoxycurcumin and bisdemethoxycurcumin, Food Chemistry, 98, 4, (2006), 720-724 https://doi.org/10.1016/j.foodchem.2005.06.037
  7. Santosh S. Dhule, Patrice Penfornis, Trivia Frazier, Ryan Walker, Joshua Feldman, Grace Tan, Jibao He, Alina Alb, Vijay John, Radhika Pochampally, Curcumin-loaded γ-cyclodextrin liposomal nanoparticles as delivery vehicles for osteosarcoma, Nanomedicine: Nanotechnology, Biology and Medicine, 8, 4, (2012), 440-451 https://doi.org/10.1016/j.nano.2011.07.011
  8. A. S. Waghmare, N. D. Grampurohit, M. V. Gadhave, D. D. Gaikwad, S. L. Jadhav, Solid lipid nanoparticles—a promising drug delivery system, International Research Journal of Pharmacy, 3, 4, (2012), 100-107
  9. Harold Gordon Cave, Improved complexes and compositions containing curcumin, WO2013176555A1, Australia, 2013
  10. I Made Budi, Fendy R. Paimin, Buah merah, Penebar Swadaya, Jakarta, 2005
  11. Marlita H. Makaruku, Kajian Agronomi dan Pemanfaatan Buah Merah (Pandanus conoideus Lamk.), Jurnal Agroforestri, 3, 2, (2008), 127-132
  12. Marsden S. Blois, Antioxidant Determinations by the Use of a Stable Free Radical, Nature, 181, 4617, (1958), 1199-1200 https://doi.org/10.1038/1811199a0
  13. Irma Irawati, Perbandingan Metode Penentuan Aktivitas Antioksidan Rimpang Temulawak, undergraduate thesis, Department of Chemistry, IPB University, Bogor, 2008
  14. Dewi Anggraini Septaningsih, Latifah Kosim Darusman, Farit Mochamad Afendi, Rudi Heryanto, Liquid Chromatography Mass Spectrometry (LC-MS) Fingerprint Combined with Chemometrics for Identification of Metabolites Content and Biological Activities of Curcuma aeruginosa, Indonesian Journal of Chemistry, 18, 1, (2018), 43-52 https://doi.org/10.22146/ijc.25456
  15. Philip Molyneux, The use of the stable free radical diphenylpicryl-hydrazyl (DPPH) for estimating antioxidant activity, Songklanakarin Journal of Science and Technology (SJST), 26, 2, (2004), 211-219
  16. Mukhriani Tetti, Ekstraksi, Pemisahan Senyawa, dan Identifikasi Senyawa Aktif, Jurnal Kesehatan, 7, 2, (2014), 361-367
  17. Agus Budiyanto, Yulianingsih, Pengaruh Suhu dan Waktu Ekstraksi Terhadap Karakter Pektin dari Ampas Jeruk Siam (Citrus nobilis L), Pengaruh suhu dan waktu ekstraksi terhadap karakter pektin dari ampas jeruk siam (Citrus nobilis L.), 5, 2, (2008), 37-44

Last update:

  1. Effect of Arabica Coffee Bean Extract (Coffea arabica) as a Growth Inhibitor of Enterococcus faecalis ATCC 29212

    Trimurti Parnomo. Journal of Drug Delivery and Therapeutics, 11 (3), 2021. doi: 10.22270/jddt.v11i3.4820

Last update: 2024-11-21 15:54:37

No citation recorded.