Research Center for Vaccine and Drug, Research Organization for Health, National Research and Innovation Agency (BRIN), Jl. Raya Jakarta-Bogor Km. 46, Cibinong-Bogor, West Java 16911, Indonesia
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@article{JKSA45841, author = {Nunik Gustini and Diah Wulandari and Fauzy Rachman and Eris Septiana and Siti Rahmawati and Gita Syahputra and Martha Sari and Masteria Putra}, title = {Antioxidant and Anticancer Activities of Sand Sea Cucumber (Holothuria scabra) Extracts using Wet Rendering Extraction Method}, journal = {Jurnal Kimia Sains dan Aplikasi}, volume = {26}, number = {1}, year = {2023}, keywords = {sea cucumber, Holothuria scabra, antioxidant, anticancer, wet rendering}, abstract = { Antioxidant and anticancer activities of sand sea cucumber Holothuria scabra (dried and fresh) extracts were studied. The highest extraction yield of sea cucumber H. scabra (3.9%) was obtained using dried H. scabra at 60 o C. The highest antioxidant activity was found in fresh H. scabra extract at 60°C with an IC 50 value of 629.89 ± 0.15 µg/mL using the ABTS method, and the highest antioxidant activity by DPPH method was found in dried H. scabra extract at 70°C with an IC 50 value of 32017.18 ± 0.82 µg/mL. The best antioxidant activity based on FRAP and TBARS methods was found in fresh H. scabra extracts at 80°C, respectively. The highest total phenol and flavonoid contained in dried H. scabra extract were 317.54 ± 8.91 mg GAE/100 g sample and 247.56 ± 11.70 mg QE/100 g sample. H. scabra extracts inhibited more than 50% of the growth of the MDA-MB-231 cell line at concentrations of 25 and 50 μg/mL except for dried H. scabra extracts at 80°C. Similarly, the extracts showed the highest cytotoxic effect up to 100% at the highest concentration (100 μg/mL) except for dried H. scabra extracts at 70°C and 80°C. }, issn = {2597-9914}, pages = {1--9} doi = {10.14710/jksa.26.1.1-9}, url = {https://ejournal.undip.ac.id/index.php/ksa/article/view/45841} }
Refworks Citation Data :
Antioxidant and anticancer activities of sand sea cucumber Holothuria scabra (dried and fresh) extracts were studied. The highest extraction yield of sea cucumber H. scabra (3.9%) was obtained using dried H. scabra at 60oC. The highest antioxidant activity was found in fresh H. scabra extract at 60°C with an IC50 value of 629.89 ± 0.15 µg/mL using the ABTS method, and the highest antioxidant activity by DPPH method was found in dried H. scabra extract at 70°C with an IC50 value of 32017.18 ± 0.82 µg/mL. The best antioxidant activity based on FRAP and TBARS methods was found in fresh H. scabra extracts at 80°C, respectively. The highest total phenol and flavonoid contained in dried H. scabra extract were 317.54 ± 8.91 mg GAE/100 g sample and 247.56 ± 11.70 mg QE/100 g sample. H. scabra extracts inhibited more than 50% of the growth of the MDA-MB-231 cell line at concentrations of 25 and 50 μg/mL except for dried H. scabra extracts at 80°C. Similarly, the extracts showed the highest cytotoxic effect up to 100% at the highest concentration (100 μg/mL) except for dried H. scabra extracts at 70°C and 80°C.
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