Potential of Prenylated Flavonoid Derivatives from Jackfruit Roots (Artocarpus heterophyllus Lam.) as Liver Anticancer Candidates: In Silico Study

Richa Mardianingrum; Meylany Sity Rossy Lestary; Nur Aji; Ruswanto Ruswanto

doi:10.14710/jksa.26.2.57-63

DOI: https://doi.org/10.14710/jksa.26.2.57-63

Potential of Prenylated Flavonoid Derivatives from Jackfruit Roots (Artocarpus heterophyllus Lam.) as Liver Anticancer Candidates: In Silico Study

Richa Mardianingrum¹

, Meylany Sity Rossy Lestary¹, Nur Aji²

, Ruswanto Ruswanto³

¹Universitas Perjuangan Tasikmalaya, Tasikmalaya, Indonesia

²Department of Pharmacy, Poltekkes Kemenkes Tasikmalaya, Tasikmalaya, Indonesia

³Universitas Bakti Tunas Husada, Tasikmalaya, Indonesia

Received: 28 Nov 2022; Revised: 15 Feb 2023; Accepted: 25 Feb 2023; Published: 28 Feb 2023.

BibTex Citation Data :

@article{JKSA50551,
    author = {Richa Mardianingrum and Meylany Sity Rossy Lestary and Nur Aji and Ruswanto Ruswanto},
    title = {Potential of Prenylated Flavonoid Derivatives from Jackfruit Roots (Artocarpus heterophyllus Lam.) as Liver Anticancer Candidates: In Silico Study},
    journal = {Jurnal Kimia Sains dan Aplikasi},
  volume = {26},
    number = {2},
    year = {2023},
    keywords = {Artocarpus heterophyllus Lam.; Cycloartocarpesin; Prenylated flavonoids; Hepatocellular carcinoma; In silico},
    abstract = {Hepatocellular carcinoma (HCC), or liver cancer, is the fourth largest cancer in Indonesia, with 21,392 new cases and around 20,920 deaths. One of the standard drugs for liver cancer patients is lenvatinib, but lenvatinib has dangerous side effects such as hypertension. Previous studies reported that jackfruit root extract ( Artocarpus heterophyllus  Lam.) contains prenylated flavonoid compounds known to have anticancer activity. This study aims to find compounds that have the potential to the anticancer liver from jackfruit root by understanding the interaction between prenylated flavonoid derivative compounds against the VEGFR2 receptor (PDB ID: 3WZE) in silico. The methods include toxicity and pharmacokinetic screening, drug scanning, docking, and molecular dynamics simulation. The toxicity, pharmacokinetic, and drug scans of cycloartocarpesin are better than lenvatinib. The docking cycloartocarpesin compound showed ∆G -8.49 kcal/mol and Ki 0.59967 M lower than lenvatinib by forming the same hydrogen bond at residue Glu885. The molecular dynamics simulation of the cycloartocarpesin compound in the MM-GBSA calculation method resulted in a ∆G total  of -56.641 kcal/mol. The cycloartocarpesin compound is predicted to be used as a candidate for liver anticancer drugs because it has better stability and affinity than lenvatinib.},
   issn = {2597-9914},   pages = {57--63}  doi = {10.14710/jksa.26.2.57-63},
    url = {https://ejournal.undip.ac.id/index.php/ksa/article/view/50551}
}

Citation Format:

Abstract

Hepatocellular carcinoma (HCC), or liver cancer, is the fourth largest cancer in Indonesia, with 21,392 new cases and around 20,920 deaths. One of the standard drugs for liver cancer patients is lenvatinib, but lenvatinib has dangerous side effects such as hypertension. Previous studies reported that jackfruit root extract (Artocarpus heterophyllus Lam.) contains prenylated flavonoid compounds known to have anticancer activity. This study aims to find compounds that have the potential to the anticancer liver from jackfruit root by understanding the interaction between prenylated flavonoid derivative compounds against the VEGFR2 receptor (PDB ID: 3WZE) in silico. The methods include toxicity and pharmacokinetic screening, drug scanning, docking, and molecular dynamics simulation. The toxicity, pharmacokinetic, and drug scans of cycloartocarpesin are better than lenvatinib. The docking cycloartocarpesin compound showed ∆G -8.49 kcal/mol and Ki 0.59967 M lower than lenvatinib by forming the same hydrogen bond at residue Glu885. The molecular dynamics simulation of the cycloartocarpesin compound in the MM-GBSA calculation method resulted in a ∆G_total of -56.641 kcal/mol. The cycloartocarpesin compound is predicted to be used as a candidate for liver anticancer drugs because it has better stability and affinity than lenvatinib.

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Keywords: Artocarpus heterophyllus Lam.; Cycloartocarpesin; Prenylated flavonoids; Hepatocellular carcinoma; In silico

Funding: Universitas Perjuangan Tasikmalaya

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Section: Research Articles

Language : EN

In Vol 26, No 2 (2023): Volume 26 Issue 2 Year 2023

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