Synthesis of Molecularly Imprinted Membrane Glucose for Selective Membrane Transport

Muhammad Cholid Djunaidi; Henita Saulia Utari; Khabibi Khabibi

doi:10.14710/jksa.26.5.178-186

DOI: https://doi.org/10.14710/jksa.26.5.178-186

Synthesis of Molecularly Imprinted Membrane Glucose for Selective Membrane Transport

Muhammad Cholid Djunaidi

, Henita Saulia Utari, Khabibi Khabibi

Department of Chemistry, Faculty of Sciences and Mathematics, Diponegoro University, Semarang, Indonesia

Received: 24 Jan 2023; Revised: 3 Jul 2023; Accepted: 17 Jul 2023; Published: 31 Jul 2023.

BibTex Citation Data :

@article{JKSA52029,
    author = {Muhammad Cholid Djunaidi and Henita Saulia Utari and Khabibi Khabibi},
    title = {Synthesis of Molecularly Imprinted Membrane Glucose for Selective Membrane Transport},
    journal = {Jurnal Kimia Sains dan Aplikasi},
  volume = {26},
    number = {5},
    year = {2023},
    keywords = {imprinted membrane; polyeugenol; polysulfone; glucose transport; selectivity},
    abstract = { Molecularly Imprinted Membrane (MIM) was synthesized using polyeugenoxy acetic acid as the functional polymer, polyethylene glycol as the crosslinker agent, and polysulfone as a base membrane which was applied as a selective glucose membrane transport, and the immersion time expected to determine the transport capability of the membrane. This study aimed to determine the selectivity and transport properties of the MIM and NIM membranes. NIM was used as a control for MIM to research the selectivity test. In comparison, MIM has a template, while NIM is without a template. In this study, eugenol derivatives were synthesized through a polymerization reaction using a BF3-diethylether catalyst polymerized for 16 hours to produce polyeugenoxy acetic acid (PA). The PA was contacted with 7500 ppm glucose. PA-glucose produced an imprinted membrane, while PA produced a non-imprinted membrane. The membrane thickness was measured with a micrometer, resulting in a measurement range of 0.08–0.10 mm. The best transport result was achieved at the membrane passage of 24 hours of immersion time because the effect of membrane immersion time can increase the porosity, hydrophilicity, and membrane’s transport ability. Transport with MIM membrane shows better and more selective results than NIM. This confirms the existence of a glucose template on the MIM membrane, which causes the MIM membrane to recognize glucose and transport glucose better than fructose. This study’s advantages include learning how immersion time affects membrane production and determining how well MIM and NIM membranes transport and select glucose and fructose. Furthermore, membrane characterizations were done using FTIR to identify functional groups, SEM-EDX to analyze the shape of the membrane, and a UV-Vis spectrophotometer to analyze the membrane’s selectivity and transport capabilities. },
   issn = {2597-9914},   pages = {178--186}  doi = {10.14710/jksa.26.5.178-186},
    url = {https://ejournal.undip.ac.id/index.php/ksa/article/view/52029}
}

Citation Format:

Abstract

Molecularly Imprinted Membrane (MIM) was synthesized using polyeugenoxy acetic acid as the functional polymer, polyethylene glycol as the crosslinker agent, and polysulfone as a base membrane which was applied as a selective glucose membrane transport, and the immersion time expected to determine the transport capability of the membrane. This study aimed to determine the selectivity and transport properties of the MIM and NIM membranes. NIM was used as a control for MIM to research the selectivity test. In comparison, MIM has a template, while NIM is without a template. In this study, eugenol derivatives were synthesized through a polymerization reaction using a BF3-diethylether catalyst polymerized for 16 hours to produce polyeugenoxy acetic acid (PA). The PA was contacted with 7500 ppm glucose. PA-glucose produced an imprinted membrane, while PA produced a non-imprinted membrane. The membrane thickness was measured with a micrometer, resulting in a measurement range of 0.08–0.10 mm. The best transport result was achieved at the membrane passage of 24 hours of immersion time because the effect of membrane immersion time can increase the porosity, hydrophilicity, and membrane’s transport ability. Transport with MIM membrane shows better and more selective results than NIM. This confirms the existence of a glucose template on the MIM membrane, which causes the MIM membrane to recognize glucose and transport glucose better than fructose. This study’s advantages include learning how immersion time affects membrane production and determining how well MIM and NIM membranes transport and select glucose and fructose. Furthermore, membrane characterizations were done using FTIR to identify functional groups, SEM-EDX to analyze the shape of the membrane, and a UV-Vis spectrophotometer to analyze the membrane’s selectivity and transport capabilities.

Fulltext View|Download

Keywords: imprinted membrane; polyeugenol; polysulfone; glucose transport; selectivity

Funding: Directorate of Research and Community Service Deputy for Strengthening Research and Development Ministry of Research and Technology / National Research and Innovation Agency under contract SPK Number : 225-70 / UN7.6.1 / PP / 2021

Article Metrics:

Article Info

Section: Research Articles

Language : EN

In Vol 26, No 5 (2023): Volume 26 Issue 5 Year 2023

Recent articles

The potential of Myricitrin, a Flavonoid Compound in Eugenia polyantha from Indonesia, as an Antiviral Drug for SARS-Cov-2 through the Molecular Docking Analysis Molecular Docking of Active Compounds of Syzygium myrtifolium Walp. Leaves on Leukotriene A4 Hydrolase Receptors as Colorectal Anticancer Biosensor based on Cellulose Acetate/Glutaraldehyde Membrane Electrodes for detection of organophosphorus pesticides More recent articles

Most cited articles

Uji Aktivitas Antioksidan Senyawa Flavonoid dari Ekstrak Etanol Daun Johar (Senna siamea Lamk) Dimerisasi Metilisoeugenol dengan Katalis HCl Modifikasi Zeolit Alam Menggunakan TiO2 sebagai Fotokatalis Zat Pewarna Indigo Carmine Removal of natural organic matter for wetland saline water desalination by coagulation-pervaporation Ekstraksi dan Uji Kestabilan Zat Warna Betasianin dari Kulit Buah Naga (Hylocereus polyrhizus) serta Aplikasinya sebagai Pewarna Alami Pangan More cited articles

H. Darmokoesoemo, L. Kustyarini, M. Khasanah, H. S. Kusuma, Analysis of glucose by potentiometry using electrode carbon paste/molecularly imprinted polymer (MIP) with metacrylic acid as monomer, Rasayan Journal of Chemistry, 10, 1, (2017), 64-68 http://dx.doi.org/10.7324/RJC.2017.1011559
Yeşeren Saylan, Semra Akgönüllü, Handan Yavuz, Serhat Ünal, Adil Denizli, Molecularly imprinted polymer based sensors for medical applications, Sensors, 19, 6, (2019), 1279 https://doi.org/10.3390/s19061279
M. Cholid Djunaidi, Yayuk Astuti, Synthesis, caracterization and selectivity of moleculary imprinted polymer (MIP) glucose using polyeugenol as a functional polymer, Rasayan Journal of Chemistry, 12, 2, (2019), 809-821
Muhammad Cholid Djunaidi, I Gede Wenten, Synthesis of eugenol-based selective membrane for hemodialysis, IOP Conference Series: Materials Science and Engineering, 2019 https://doi.org/10.1088/1757-899X/509/1/012069
M. Cholid Djunaidi, Jumina Jumina, Dwi Siswanta, Mathias Ulbricht, Synthesis of Fe Ionic-Imprinted Polyeugenol Using Polyethylene Glycol Diglycidilether as Cross-Linking Agent for Sorption of Fe(III), Indonesian Journal of Chemical Science, 15, 3, (2015), 305-314 https://doi.org/10.22146/ijc.21200
M. Cholid Djunaidi, Jumina, Dwi Siswanta, Mathias Ulbricht, Synthesis of ionic imprinted polymer particles for selective membrane transport of Fe (III) using polyeugenol as the functional polymer, Oriental Journal of Chemistry, 32, 1, (2016), 77-84 http://dx.doi.org/10.13005/ojc/320107
M. Cholid Djunaidi, Jumina, Dwi Siswanta, Mathias Ulbricht, Selective transport of Fe (III) using polyeugenol as functional polymer with ionic imprinted polymer membrane method, Asian Journal of Chemistry, 27, 12, (2015), 4553-4562 https://doi.org/10.14233/ajchem.2015.19228
Peimin Fan, Bing Wang, Preparation of molecularly imprinted polymer membrane with blending trimethoprim-MIP and polysulfone and its transport properties, Korean Journal of Chemical Engineering, 26, (2009), 1813-1820 https://doi.org/10.1007/s11814-009-0256-x
Muhammad Cholid Djunaidi, Nor Basid Adiwibawa Prasetya, Arini Khoiriyah, Pardoyo Pardoyo, Abdul Haris, Nabilah Anindita Febriola, Polysulfone influence on Au selective adsorbent imprinted membrane synthesis with sulfonated polyeugenol as functional polymer, Membranes, 10, 12, (2020), 390 https://doi.org/10.3390/membranes10120390
Muhammad Cholid Djunaidi, Nabilah Anindita Febriola, Abdul Haris, Molecularly imprinted membrane for transport of urea, creatinine, and vitamin B12 as a hemodialysis candidate membrane, Open Chemistry, 19, 1, (2021), 806-817
Yan‐Qiu Song, Jing Sheng, Min Wei, Xu‐Bo Yuan, Surface modification of polysulfone membranes by low‐temperature plasma–graft poly (ethylene glycol) onto polysulfone membranes, Journal of Applied Polymer Science, 78, 5, (2000), 979-985 https://doi.org/10.1002/1097-4628(20001031)78:5%3C979::AID-APP60%3E3.0.CO;2-U
Sonia Scorrano, Lucia Mergola, Maria Pia Di Bello, Maria Rosaria Lazzoi, Giuseppe Vasapollo, Roberta Del Sole, Molecularly imprinted composite membranes for selective detection of 2-deoxyadenosine in urine samples, International Journal of Molecular Sciences, 16, 6, (2015), 13746-13759 https://doi.org/10.3390/ijms160613746
Cristina Cattò, Francesca Cappitelli, Testing anti-biofilm polymeric surfaces: Where to start?, International Journal of Molecular Sciences, 20, 15, (2019), 3794 https://doi.org/10.3390/ijms20153794
Cynthia L. Radiman, Yuliany Yuliany, Veinardi Suendo, Pengaruh Media Perendam Terhadap Permeabilitas Membran Polisulfon, Jurnal Matematika dan Sains, 7, 2, (2009), 77-83
Aazam Jalali, Abbas Shockravi, Vahid Vatanpour, Mohsen Hajibeygi, Preparation and characterization of novel microporous ultrafiltration PES membranes using synthesized hydrophilic polysulfide-amide copolymer as an additive in the casting solution, Microporous and Mesoporous Materials, 228, (2016), 1-13 https://doi.org/10.1016/j.micromeso.2016.03.024
Retno Ariadi Lusiana, Nor Basid Adiwibawa Prasetya, Khabibi Khabibi, Pengaruh Penambahan Aditif terhadap Karakterisasi Fisikokimia Membran Polisulfon, Indonesian Journal of Chemical Science, 9, 3, (2020), 194-200
S. Velu, L. Muruganandam, G. Arthanareeswaran, Preparation and performance studies on polyethersulfone ultrafiltration membranes modified with gelatin for treatment of tannery and distillery wastewater, Brazilian Journal of Chemical Engineering, 32, 1, (2015), 179-189 https://doi.org/10.1590/0104-6632.20150321s00002965
Retno Ariadi Lusiana, Diana Pratiwi Rusendi, Didik Setiyo Widodo, Abdul Haris, Ahmad Suseno, Gunawan Gunawan, Studi Sifat Fisikokimia Membran Kitosan Termodifikasi Heparin dan Polietilen Glikol (PEG), Analit: Analytical and Environmental Chemistry, 4, 2, (2019), 1-13 http://dx.doi.org/10.23960/aec.v4.i2.2019.p01-13
Afaf Sri Hartini, Nurlina Intan Syahbanu, Uji Water Uptake dan Porositas Terhadap Blend Membran Berbasis Polisulfon dan Selulosa Asetat dari Nata De Coco, Jurnal Kimia Khatulistiwa, 7, 4, 25-30
Muhammad Cholid Djunaidi, Nesti Dwi Maharani, Pardoyo, Yanuardi Raharjo, Eugenol-based molecularly imprinted membrane synthesis for glucose selective transport, AIP Conference Proceedings, 2553, (2022), 020022 https://doi.org/10.1063/5.0104444

Last update:

No citation recorded.

Last update: 2024-05-07 10:06:32

No citation recorded.

As an article writer, the author has the right to use their articles for various purposes, including use by institutions that employ authors or institutions that provide funding for research. Author rights are granted without special permission.

Author who publishes a paper at JKSA has the broad right to use their work for teaching and scientific purposes without the need to ask permission, including: used for (i) teaching in the author's class or institution, (ii) presentation at meetings or conferences and distributing copies to participants ; (iii) training conducted by the author or author's institution; (iv) distribution to colleagues for research use; (v) use in the compilation of subsequent authors' works; (vi) inclusion in a thesis or dissertation; (vi) reuse of part of the article in another work (with citation); (vii) preparation of derivative works (with citation); (viii) voluntary posting on open websites operated by authors or author institutions for scientific purposes (follow the CC BY-SA License).

Authors and readers can copy and redistribute material in any media or format, and mix, modify, and build material for any purpose but they must provide appropriate credit (provide article citation or content), providing links to the license, and indicate if there are changes.

The authors submitting a manuscript do so on the understanding that if accepted for publication, copyright of the article shall be assigned to Jurnal Kimia Sains dan Aplikasi (JKSA). Copyright encompasses rights to reproduce and deliver the article in all form and media, including reprints, photographs, microfilms and any other similar reproductions, as well as translations.

Reproduce any part of this journal, its storage in the database or its transmission by all forms or media is permitted does not need for written permission from JKSA. However, it should be cited as an honor in academic manners

JKSA and the Chemistry Department of Diponegoro University and the Editor make every effort to ensure that there are no data, opinions, or false or misleading statements published in JKSA. However, the content of the article is the sole and exclusive responsibility of each author.

The Copyright Transfer Form can be downloaded here: [Copyright Transfer Form - Indonesian] [Copyright Transfer Form - English]. The copyright form should be signed originally and send to the Editor in the form of printed letters, scanned documents sent via email or fax.

Adi Darmawan, Ph.D (Editor in Chief)

Editor in chief of Jurnal Kimia Sains dan Aplikasi (JKSA)

Chemistry Department, Faculty of Sciences and Mathematics, Diponegoro University

Jl. Prof. Soedarto, Kampus Undip Tembalang, Semarang, Central Java, Indonesia 50275
Email: jksa@live.undip.ac.id