Chemistry Education Study Program, Faculty of Teacher Training and Education, Universitas Sebelas Maret, Surakarta, Indonesia
BibTex Citation Data :
@article{JKSA68078, author = {Elfi V. H. and Sri Mulyani and Sri Dwi Ariani and Suryadi Utomo and Muhammad Wathon and Widiastuti Eko Setyowati}, title = {Green Synthesis of 4-Nitro-4’-Methoxy Chalcone by Grinding Technique and its Antibacterial Activity}, journal = {Jurnal Kimia Sains dan Aplikasi}, volume = {27}, number = {12}, year = {2024}, keywords = {grinding; chalcone; Claisen Schmidt; antibacterial}, abstract = { This research aims to synthesize 4-nitro-4’-methoxy chalcone and determine the potential of 4-nitro-4’-methoxy chalcone as an antibacterial against Staphylococcus aureus and Escherichia coli bacteria. The synthesis of 4-nitro-4’-methoxy chalcone was carried out using the grinding technique, an environmentally friendly green synthesis approach—characterization of the synthesized chalcone using FTIR, 1 H-NMR, and 13 C-NMR. The research demonstrated that 4-nitro-4’-methoxy chalcone could be synthesized via grinding techniques using 4-methoxyacetophenone, 4-nitrobenzaldehyde, and NaOH as catalysts. The synthetic process achieved higher yields and was environmentally friendly due to the absence of organic solvents. The resulting product was yellow crystalline with a yield of 54.42% and a melting point of 172°C–173°C. Antibacterial activity tests revealed that the synthesized chalcone exhibited greater inhibition against E. coli than S. aureus . This was evidenced by the clear zones formed (9.57 mm for S. aureus and 12.46 mm for E. coli ), indicating that 4-nitro-4’-methoxy chalcone possesses strong antibacterial activity. }, issn = {2597-9914}, pages = {597--602} doi = {10.14710/jksa.27.12.597-602}, url = {https://ejournal.undip.ac.id/index.php/ksa/article/view/68078} }
Refworks Citation Data :
This research aims to synthesize 4-nitro-4’-methoxy chalcone and determine the potential of 4-nitro-4’-methoxy chalcone as an antibacterial against Staphylococcus aureus and Escherichia coli bacteria. The synthesis of 4-nitro-4’-methoxy chalcone was carried out using the grinding technique, an environmentally friendly green synthesis approach—characterization of the synthesized chalcone using FTIR, 1H-NMR, and 13C-NMR. The research demonstrated that 4-nitro-4’-methoxy chalcone could be synthesized via grinding techniques using 4-methoxyacetophenone, 4-nitrobenzaldehyde, and NaOH as catalysts. The synthetic process achieved higher yields and was environmentally friendly due to the absence of organic solvents. The resulting product was yellow crystalline with a yield of 54.42% and a melting point of 172°C–173°C. Antibacterial activity tests revealed that the synthesized chalcone exhibited greater inhibition against E. coli than S. aureus. This was evidenced by the clear zones formed (9.57 mm for S. aureus and 12.46 mm for E. coli), indicating that 4-nitro-4’-methoxy chalcone possesses strong antibacterial activity.
Article Metrics:
Last update:
Last update: 2026-09-01 19:05:21
As an article writer, the author has the right to use their article for various purposes, including use by institutions that employ the author or institutions that provide funding for the research. These author rights are granted without special permission.
Authors who publish a paper in JKSA have broad rights to use their work for teaching and scientific purposes without the need to request permission, including: (i) teaching in the author's class or institution; (ii) presenting the work at meetings or conferences and distributing copies to participants; (iii) using the work in training conducted by the author or the author's institution; (iv) distributing copies to colleagues for research purposes; (v) using the work in the compilation of subsequent works by the author; (vi) including the work in a thesis or dissertation; (vii) reusing part of the article in another work, with appropriate citation; (viii) preparing derivative works, with appropriate citation; and (ix) voluntarily posting the work on open websites operated by the author or the author's institution for scientific purposes, in accordance with the CC BY-SA License.
Authors and readers may copy and redistribute the material in any medium or format, and may remix, transform, and build upon the material for any purpose, provided that they give appropriate credit by citing the article or its content, provide a link to the license, and indicate if changes were made.
The authors submitting a manuscript do so on the understanding that, if accepted for publication, the copyright of the article shall be assigned to Jurnal Kimia Sains dan Aplikasi (JKSA). Copyright encompasses the rights to reproduce and distribute the article in all forms and media, including reprints, photographs, microfilms, and any other similar reproductions, as well as translations.
Reproducing any part of this journal, storing it in a database, or transmitting it in any form or medium is permitted without written permission from JKSA. However, the original source must be properly cited in accordance with academic conventions.
JKSA, the Chemistry Department of Diponegoro University, and the Editor make every effort to ensure that no inaccurate, false, or misleading data, opinions, or statements are published in JKSA. However, the content of each article is the sole and exclusive responsibility of its authors.
The Copyright Transfer Form can be downloaded here: [Copyright Transfer Form - Indonesian] [Copyright Transfer Form - English]. The copyright form should bear the authors' original signatures and be sent to the Editor as a printed document, a scanned document sent via email, or by fax.
Prof. Adi Darmawan, Ph.D (Editor in Chief)
Editor in chief of Jurnal Kimia Sains dan Aplikasi (JKSA)
Chemistry Department, Faculty of Sciences and Mathematics, Diponegoro University
Visitor: View My Stats
Jurnal Kimia Sains dan Aplikasi is indexed in:
This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.
