DOI: https://doi.org/10.14710/jil.20.3.628-636

Pengaruh Paparan Pencemar Udara Terhadap Stres Oksidatif: Sistematik Review

1Program Studi Sanitasi Poltekkes Kemenkes Kupang, Indonesia

2Program Studi Teknologi Laboratorium Medis Poltekkes Kemenkes Kupang, Indonesia

3Program Studi Keperawatan Poltekkes Kemenkes Kupang, Indonesia

4 Program Studi Sanitasi, Politeknik Kesehatan Kemenkes Kupang, Indonesia

View all affiliations
Received: 24 Feb 2022; Revised: 13 Mar 2022; Accepted: 21 Mar 2022; Available online: 2 Apr 2022; Published: 5 Jul 2022.
Editor(s): H. Hadiyanto

Citation Format:
Abstract

Pencemaran udara mempengaruhi kualitas lingkungan dan kesehatan masyarakat.  Pencemar udara dapat menyebabkan perubahan molekul dalam tubuh sebagai penanda dini gangguan kesehatan. Tujuan penelitian ini adalah memperoleh gambaran tentang pengaruh pencemar udara terhadap stres oksidatif. Jenis penelitian adalah sistematik review dari artikel penelitian yang dilakukan sebelumnya. Penelitian dilaksanakan pada Apri-Mei 2021. Pencarian literature dilakukan melalui data base Science Direct pada periode publikasi 2017-2021.  Kata kunci yang digunakan adalah “air pollutant” OR “oxidative stress” AND “air pollution” OR “oxidative stress”.   Artikel yang diperoleh menggunakan kata kunci dan memenuhi kriteria inklusi selanjutnya dilakukan penilaian kelayakan menggunakan The JBI Critical Appraisal.  Dari menilaian kelayakan diperoleh 15 artikel dari data base Science Direct yang selanjutnya ditelaah. Hasil pdari penelusuran literature diketahui jenis pencemar udara antara lain PM2,5, NO2, Ozon, partikulat, PM10, PM2.5, NO2, dan CO, PM udara ambien, abu vulkanik, bahan bakar dan sebagainya. Paparan polutan udara dapat menyebabkan stress oksidatif dalam berbagai penanda antara lain peningkatan produksi spesies oksigen reaktif, penurunan antioksidan, 8-OHDG.  Kesimpulan dari penelitian ini bahwa pajanan pencemar udara menyebabkan perubahan pada penanda biologis stress oksidatif yang merupakan indikasi dini adanya gangguan kesehatan sebagai dampak dari pencemar udara.  Perlu upaya pengendalian pencemaran udara agar tidak menimbulkan dampak negatif pada manusia.

ABSTRACT

Air pollution had an impact on environmental quality and public health. Air pollutants could cause molecular changes in the body as an early marker of health problems. The purpose of this study was to obtain an overview of the effect of air pollutants on oxidative stress. This study was a systematic review of previous research articles. The research was carried out in April-May 2021. The literature search was carried out through the Science Direct database in the 2017-2021 publication period. The keywords used were “air pollutant” OR “oxidative stress” AND “air pollution” OR “oxidative stress”. Articles obtained using keywords and meeting the inclusion criteria were then assessed for feasibility using The JBI Critical Appraisal. From the feasibility assessment, 15 articles were obtained which were then reviewed. The results of a literature search showed that the types of air pollutants include PM2.5, NO2, Ozone, particulates, PM10, PM2.5, NO2, and CO, ambient air PM, volcanic ash, fuel and so on. Exposure to air pollutants caused oxidative stress in various markers, including increased production of reactive oxygen species, decreased antioxidants, 8-OHDG. The conclusion of this study is that exposure to air pollutants causes changes in biological markers of oxidative stress which is an early indication of health problems as a result of air pollutants. Efforts are needed to control air pollution so that it does not have a negative impact on humans.

Fulltext View|Download
Keywords: pencemar; udara; review; stress oksidatif; antioksidan
Funding: Poltekkes Kemenkes Kupang

Article Metrics:

Article Info
Section: Research Article
Language : ID
Recent articles
Proyeksi Konservasi Tanah dan Air Mitigasi Penurunan Jasa Lingkungan Tata Hidrologi DAS Hulu Brantas Analisis Korelasi Tingkat Pemahaman Masyarakat terhadap Perilaku Pemilahan dan Pengolahan Sampah di Dusun Pade Mare Lombok Utara Evaluasi Aspek Teknis Operasional Pengelolaan Persampahan di Kecamatan Putussibau Utara Kabupaten Kapuas Hulu More recent articles
Most cited articles
ANALISIS PEMANFAATAN RUANG YANG BERWAWASAN LINGKUNGAN DI KAWASAN PESISIR KOTA TEGAL Melihat Kondisi Kesetimbangan Ekologi Terumbu Karang di Pulau Sempu, Malang Menggunakan Pendekatan Luasan Koloni Karang Keras (Scleractinia) APLIKASI FITOREMEDIASI LIMBAH JAMU DAN PEMANFAATANNYA UNTUK PRODUKSI PROTEIN STUDI DAMPAK EL NINO DAN INDIAN OCEAN DIPOLE (IOD) TERHADAP CURAH HUJAN DI PANGKALPINANG Menakar Kapasitas Adaptasi Perubahan Iklim Petani Padi Sawah (Kasus Kabupaten Pasuruan Jawa Timur) More cited articles
  1. Alrashed, M., Tabassum, H., Almuhareb, N., Almutlaq, N., Alamro, W., Alanazi, S. T., Alenazi, F. K., Alahmed, L. B., Al Abudahash, M. M., & Alenzi, N. D. (2021). Assessment of DNA damage in relation to heavy metal induced oxidative stress in females with recurrent pregnancy loss (RPL). Saudi Journal of Biological Sciences, 28(9), 5403–5407. https://doi.org/10.1016/j.sjbs.2021.05.068
  2. Cáceres, L., Paz, M. L., Garcés, M., Calabró, V., Magnani, N. D., Martinefski, M., Martino Adami, P. V., Caltana, L., Tasat, D., Morelli, L., Tripodi, V., Valacchi, G., Alvarez, S., González Maglio, D., Marchini, T., & Evelson, P. (2020). NADPH oxidase and mitochondria are relevant sources of superoxide anion in the oxinflammatory response of macrophages exposed to airborne particulate matter. Ecotoxicology and Environmental Safety, 205(May). https://doi.org/10.1016/j.ecoenv.2020.111186
  3. de Oliveira Alves, N., Martins Pereira, G., Di Domenico, M., Costanzo, G., Benevenuto, S., de Oliveira Fonoff, A. M., de Souza Xavier Costa, N., Ribeiro Júnior, G., Satoru Kajitani, G., Cestari Moreno, N., Fotoran, W., Iannicelli Torres, J., de Andrade, J. B., Matera Veras, M., Artaxo, P., Menck, C. F. M., de Castro Vasconcellos, P., & Saldiva, P. (2020). Inflammation response, oxidative stress and DNA damage caused by urban air pollution exposure increase in the lack of DNA repair XPC protein. Environment International, 145. https://doi.org/10.1016/j.envint.2020.106150
  4. Feng, R., Xu, H., He, K., Wang, Z., Han, B., Lei, R., Ho, K. F., Niu, X., Sun, J., Zhang, B., Liu, P., & Shen, Z. (2021). Effects of domestic solid fuel combustion emissions on the biomarkers of homemakers in rural areas of the Fenwei Plain, China. Ecotoxicology and Environmental Safety, 214, 112104. https://doi.org/10.1016/j.ecoenv.2021.112104
  5. Ferrante, M., Fiore, M., Conti, G. O., Ledda, C., Fallico, R., Sciacca, S., Martins, H., Miranda, A., Borrego, C., Arslan, S., Aybek, A., Serrano-bernardo, F. A., Bruzzi, L., Toscano, E. H., & Rosúa-campos, J. L. (2012). AIR POLLUTION – A COMPREHENSIVE Edited by Budi Haryanto
  6. Fussell, J. C., & Kelly, F. J. (2020). Oxidative contribution of air pollution to extrinsic skin ageing. Free Radical Biology and Medicine, 151(October 2019), 111–122. https://doi.org/10.1016/j.freeradbiomed.2019.11.038
  7. Gangwar, R. S., Bevan, G. H., Palanivel, R., Das, L., & Rajagopalan, S. (2020). Oxidative stress pathways of air pollution mediated toxicity: Recent insights. Redox Biology, 34(May), 101545. https://doi.org/10.1016/j.redox.2020.101545
  8. Gao, J., Yuan, J., Wang, Q., Lei, T., Shen, X., Cui, B., Zhang, F., Ding, W., & Lu, Z. (2020). Metformin protects against PM2.5-induced lung injury and cardiac dysfunction independent of AMP-activated protein kinase α2. Redox Biology, 28(September 2019), 101345. https://doi.org/10.1016/j.redox.2019.101345
  9. Hajat, A., Hazlehurst, M. F., Golden, S. H., Merkin, S. S., Seeman, T., Szpiro, A. A., Kaufman, J. D., & Roux, A. D. (2019). The cross-sectional and longitudinal association between air pollution and salivary cortisol: Evidence from the Multi-Ethnic Study of Atherosclerosis. Environment International, 131(April), 105062. https://doi.org/10.1016/j.envint.2019.105062
  10. Hashemzadeh, B., Idani, E., Goudarzi, G., Ankali, K. A., Sakhvidi, M. J. Z., Akbar Babaei, A., Hashemzadeh, H., Vosoughi, M., Mohammadi, M. J., & Neisi, A. (2019). Effects of PM 2.5 and NO 2 on the 8-isoprostane and lung function indices of FVC and FEV 1 in students of Ahvaz city, Iran. Saudi Journal of Biological Sciences, 26(3), 473–480. https://doi.org/10.1016/j.sjbs.2016.11.008
  11. Isaevska, E., Moccia, C., Asta, F., Cibella, F., Gagliardi, L., Ronfani, L., Rusconi, F., Stazi, M. A., & Richiardi, L. (2021). Exposure to ambient air pollution in the first 1000 days of life and alterations in the DNA methylome and telomere length in children: A systematic review. Environmental Research, 193, 110504. https://doi.org/10.1016/j.envres.2020.110504
  12. Jiang, N., Wen, H., Zhou, M., Lei, T., Shen, J., Zhang, D., Wang, R., Wu, H., Jiang, S., & Li, W. (2020). Low-dose combined exposure of carboxylated black carbon and heavy metal lead induced potentiation of oxidative stress, DNA damage, inflammation, and apoptosis in BEAS-2B cells. Ecotoxicology and Environmental Safety, 206(July), 111388. https://doi.org/10.1016/j.ecoenv.2020.111388
  13. Kelly, F. J., & Fussell, J. C. (2017). Role of oxidative stress in cardiovascular disease outcomes following exposure to ambient air pollution. Free Radical Biology and Medicine, 110(January), 345–367. https://doi.org/10.1016/j.freeradbiomed.2017.06.019
  14. Kusmiyati, Keman, S., Amin, M., & Suwarno. (2018). Expression of Catalase and Malondialdehyde Levels in Silicon Dioxyde-exposed Lung Tissue of Mice Treated with Moringa oleifera Leaves Extract 323 | Publisher : Humanistic Network for Science and Technology. Health Notions, 2(3), 323–331
  15. Lee, E. Y., Oh, S. S., White, M. J., Eng, C. S., Elhawary, J. R., Borrell, L. N., Nuckton, T. J., Zeiger, A. M., Keys, K. L., Mak, A. C. Y., Hu, D., Huntsman, S., Contreras, M. G., Samedy, L. A., Goddard, P. C., Salazar, S. L., Brigino-Buenaventura, E. N., Davis, A., Meade, K. E., … Balmes, J. R. (2019). Ambient air pollution, asthma drug response, and telomere length in African American youth. Journal of Allergy and Clinical Immunology, 144(3), 839-845.e10. https://doi.org/10.1016/j.jaci.2019.06.009
  16. Miller, M. R. (2020). Oxidative stress and the cardiovascular effects of air pollution. Free Radical Biology and Medicine, 151(January), 69–87. https://doi.org/10.1016/j.freeradbiomed.2020.01.004
  17. Mudway, I. S., Kelly, F. J., & Holgate, S. T. (2020). Oxidative stress in air pollution research. Free Radical Biology and Medicine, 151(May), 2–6. https://doi.org/10.1016/j.freeradbiomed.2020.04.031
  18. Rouadi, P. W., Idriss, S. A., Naclerio, R. M., Peden, D. B., Ansotegui, I. J., Canonica, G. W., Gonzalez-Diaz, S. N., Rosario Filho, N. A., Ivancevich, J. C., Hellings, P. W., Murrieta-Aguttes, M., Zaitoun, F. H., Irani, C., Karam, M. R., & Bousquet, J. (2020). Immunopathological features of air pollution and its impact on inflammatory airway diseases (IAD). World Allergy Organization Journal, 13(10), 100467. https://doi.org/10.1016/j.waojou.2020.100467
  19. Salvi, A., Liu, H., & Salim, S. (2020). Involvement of oxidative stress and mitochondrial mechanisms in air pollution-related neurobiological impairments. Neurobiology of Stress, 12(December 2019), 100205. https://doi.org/10.1016/j.ynstr.2019.100205
  20. Thomson, E. M., Filiatreault, A., & Guénette, J. (2019). Stress hormones as potential mediators of air pollutant effects on the brain: Rapid induction of glucocorticoid-responsive genes. Environmental Research, 178(September), 108717. https://doi.org/10.1016/j.envres.2019.108717
  21. Tomašek, I., Horwell, C. J., Bisig, C., Damby, D. E., Comte, P., Czerwinski, J., Petri-Fink, A., Clift, M. J. D., Drasler, B., & Rothen-Rutishauser, B. (2018). Respiratory hazard assessment of combined exposure to complete gasoline exhaust and respirable volcanic ash in a multicellular human lung model at the air-liquid interface. Environmental Pollution, 238, 977–987. https://doi.org/10.1016/j.envpol.2018.01.115
  22. Vogel, C. F. A., Van Winkle, L. S., Esser, C., & Haarmann-Stemmann, T. (2020). The aryl hydrocarbon receptor as a target of environmental stressors – Implications for pollution mediated stress and inflammatory responses. Redox Biology, 34(February), 101530. https://doi.org/10.1016/j.redox.2020.101530
  23. Wang, X., Hart, J. E., Liu, Q., Wu, S., Nan, H., & Laden, F. (2020). Association of particulate matter air pollution with leukocyte mitochondrial DNA copy number. Environment International, 141(January), 105761. https://doi.org/10.1016/j.envint.2020.105761
  24. Xu, F., Shi, X., Qiu, X., Jiang, X., Fang, Y., Wang, J., Hu, D., & Zhu, T. (2020). Investigation of the chemical components of ambient fine particulate matter (PM2.5) associated with in vitro cellular responses to oxidative stress and inflammation. Environment International, 136(January). https://doi.org/10.1016/j.envint.2020.105475
  25. Yan, Q., Liew, Z., Uppal, K., Cui, X., Ling, C., Heck, J. E., von Ehrenstein, O. S., Wu, J., Walker, D. I., Jones, D. P., & Ritz, B. (2019). Maternal serum metabolome and traffic-related air pollution exposure in pregnancy. Environment International, 130(February), 104872. https://doi.org/10.1016/j.envint.2019.05.066
  26. Yue, W., Tong, L., Liu, X., Weng, X., Chen, X., Wang, D., Dudley, S. C., Weir, E. K., Ding, W., Lu, Z., Xu, Y., & Chen, Y. (2019). Short term Pm2.5 exposure caused a robust lung inflammation, vascular remodeling, and exacerbated transition from left ventricular failure to right ventricular hypertrophy. Redox Biology, 22(March), 101161. https://doi.org/10.1016/j.redox.2019.101161
  27. Zhang, G., Jiang, F., Chen, Q., Yang, H., Zhou, N., Sun, L., Zou, P., Yang, W., Cao, J., Zhou, Z., & Ao, L. (2020). Associations of ambient air pollutant exposure with seminal plasma MDA, sperm mtDNA copy number, and mtDNA integrity. Environment International, 136(January), 105483. https://doi.org/10.1016/j.envint.2020.105483
  28. Zhao, Y., Xue, L., Chen, Q., Kou, M., Wang, Z., Wu, S., Huang, J., & Guo, X. (2020). Cardiorespiratory responses to fine particles during ambient PM2.5 pollution waves: Findings from a randomized crossover trial in young healthy adults. Environment International, 139(February), 105590. https://doi.org/10.1016/j.envint.2020.105590

Last update:

No citation recorded.

Last update: 2024-11-20 00:34:47

No citation recorded.