Perbedaan Pemberian Midazolam dan Ketamin Terhadap PaCO2 dan HCO3 pada Pasien dengan Ventilator

Tujuan: Mengetahui perbedaan nilai PaCO2 dan HCO3 darah arteri pasien yang dirawat di URI yang menerima midazolam dibandingkan dengan ketamin.
Metode: Penelitian ini merupakan uji klinik eksperimental acak tersamar ganda pada subjek yang menggunakan ventilator di URI. Subjek (n : 28) dibagi menjadi K1 yang mendapat sedasi ketamin dan K2 yang mendapat midazolam. Sedasi diberikan selama 24 jam, dosis bervariasi, target Ramsay Score 3. Diperiksa nilai analisis gas darah pada jam ke- 0, 6 dan 24.
Hasil: Hasil perbandingan pada jam ke- 0 dan ke- 24 kelompok K1 dan K2 nilai HCO3 p=0,565 (p>0,05). Nilai PaCO2 menunjukkan kemaknaan sebesar p=0,12 (p>0,05)
Kesimpulan : Terdapat perbedaan yang tidak bermakna pada penggunaan ketamin maupun midazolam sebagai sedasi terhadap nilai PaCO2 dan HCO3 pada subjek yang menggunakan ventilator antara jam ke- 0 dan ke- 24.
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Last update: 2021-04-18 16:51:04
Last update: 2021-04-18 16:51:04
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