Chemistry Department, Faculty of Sciences and Mathematics, Diponegoro University, Indonesia
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@article{JKSA16718, author = {Dian Nopitasari and Enny Fachriyah and Pratama Wibawa}, title = {Triterpenoid dan Nanopartikel Ekstrak n-Heksana dari Rimpang Lengkuas Merah (Alpinia purpurata (Vieill.) K. Schum) Serta Uji Sitotoksisitas dengan BSLT}, journal = {Jurnal Kimia Sains dan Aplikasi}, volume = {20}, number = {3}, year = {2017}, keywords = {Triterpenoid; nanopartikel; ekstrak n-Heksana; Rimpang Lengkuas Merah; Alpinia purpurata (Vieill.) K. Schum}, abstract = {Penelitian ini bertujuan untuk mengisolasi senyawa triterpenoid dari rimpang Alpinia purpurata dan fabrikasi nanopartikel ekstrak n -heksana serta membandingkan aktivitas sitotoksik antara nanopartikel dan ekstrak n -heksana. Senyawa triterpenoid diisolasi dari ekstrak n -heksana menggunakan kromatografi kolom gravitasi dan KLT Preparatif. Metode yang digunakan untuk fabrikasi ekstrak n -heksana menjadi nanopartikel adalah sonikasi dengan menggunakan prosesor ultrasonik. Penentuan aktivitas sitotoksik ekstrak n -heksana menggunakan metode BSLT ( Brine Shrimp Lethality Test ). Hasil analisis GC-MS isolat triterpenoid memiliki berat molekul sebesar 426 g/mol diduga merupakan senyawa Lupeol. Berdasarkan analisis ukuran partikel menggunakan instrumen PSA, nanopartikel ekstrak n -heksana memiliki ukuran 278,0 nm. Hasil uji sitotoksisitas ekstrak n -heksana dan nanopartikel ekstrak n -heksana menghasilkan LC 50 berturut-turut sebesar 109,668 ppm dan 86,783 ppm. Ekstrak n-heksana dalam bentuk nanopartikel dapat meningkatkan bioaktivitas.}, issn = {2597-9914}, pages = {117--122} doi = {10.14710/jksa.20.3.117-122}, url = {https://ejournal.undip.ac.id/index.php/ksa/article/view/16718} }
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