Design New Compound of Meisoindigo Derivative as Anti Breast Cancer Based on QSAR Approach

*Agus Dwi Ananto  -  Department of Pharmacy, Faculty of Health, University of Mataram, Indonesia
Handa Muliasari  -  Department of Pharmacy, Faculty of Health, University of Mataram, Indonesia
Saprizal Hadisaputra  -  Department of Educational Chemistry, FKIP, University of Mataram, Indonesia
Received: 6 Dec 2019; Revised: 17 Jul 2020; Accepted: 6 Aug 2020; Published: 30 Sep 2020.
Open Access Copyright 2020 Jurnal Kimia Sains dan Aplikasi
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Section: 8th - International Conference of the Indonesian Chemical Society (ICICS)
Language: EN
Statistics: 130 39
Design new compounds of Meisoindigo using the QSAR approach with semiempirical methods have been successfully made with better biological activity as anti-breast cancer results. The research method used to design the new compound of meisoindigo derivatives uses the semiempirical methods. The research procedure divide into tree step, molecular modeling, QSAR equation analysis, and design of new compounds. The PM3 method was chosen as a better method because it has model results that are more representative of physicochemical aspects. The selection of the best model is made by multilinear regression statistical analysis. New compounds derived from the design are expected to bind to the Cyclin-Dependent Kinase 4 (CDK4) enzyme that helps in the cell cycle to prevent cell division. Based on the design, the compound of (E)-2-(2-oxo-1-(2-(trifluoromethyl) benzyl)indolin-3-ylidene)-N-(quinoline-7-yl) acetamide choose as a new compound with more better biological activity (log 1/IC50 = 6.992) than before (log 1/IC50 = 5.823)
Keywords: QSAR; meisoindigo; Cyclin-Dependent Kinase 4

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