skip to main content

Green Synthesis of Silver Nanoparticles using Kayu tulak Leaf (Schefflera Elliptica Harms) Infusion as a Bio-reductant and Its Antibacterial Activity

Program Studi Teknologi Laboratorium Medik, Universitas Bali Internasional, Denpasar, Bali, Indonesia

Received: 18 Feb 2022; Revised: 18 May 2022; Accepted: 11 Jul 2022; Published: 31 Jul 2022.
Open Access Copyright 2022 Jurnal Kimia Sains dan Aplikasi under http://creativecommons.org/licenses/by-sa/4.0.

Citation Format:
Cover Image
Abstract

Metal nanoparticles and exploration of green synthesis can be applied to lung tissue therapy, cancer, and even vaccines. Additionally, due to the rise in microbial resistance or the demand for novel antibiotics, the use of NPs as an antibacterial agent has expanded. Meanwhile, using methods to produce metal nanoparticles based on the abundance of biodiversity as a green-reducing agent will be safer. In the present study, Kayu tulak leaves extract served as the green-reducing agent. The synthesized silver nanoparticles were characterized using a UV-Vis spectrophotometer, PSA (Particle Size Analyzer), and TEM (Transmission Electron Microscope). The results showed that the silver nanoparticles synthesized using Kayu tulak leaf extract at concentrations of AgNO3 1 and 2 mM had absorbance peaks at 436.5 nm and 467 nm, respectively. The average particle size distributions of the two silver nanoparticles were 88.2 and 16.9 nm, respectively. The characterization of silver nanoparticles using TEM obtained a mixture of spherical, hexagonal, and triangular shapes. The silver nanoparticles synthesized using Kayu tulak as a bio-reductant exhibited antibacterial activity. At AgNO3 solutions of 1 and 2 mM, silver nanoparticles showed antibacterial activity against Escherichia coli with inhibition zone diameters of 6.39 ± 0.30 mm and 8.28 ± 0.19 mm (moderate inhibition), while against Staphylococcus aureus were 4.30 ± 0.24 mm (weak inhibition) and 6.39 ± 0.27 mm (moderate inhibition).

Fulltext View|Download
Keywords: Silver nanoparticles; Kayu tulak leaf; bio-reductant; Escherichia coli; Staphylococcus aureus
Funding: Bali International University

Article Metrics:

  1. A. J. Thorley, T. D. Tetley, New perspectives in nanomedicine, Pharmacology & Therapeutics, 140, 2, (2013), 176-185 https://doi.org/10.1016/j.pharmthera.2013.06.008
  2. Deborah M. Aruguete, Bojeong Kim, Michael F. Hochella, Yanjun Ma, Yingwen Cheng, Andy Hoegh, Jie Liu, Amy Pruden, Antimicrobial nanotechnology: its potential for the effective management of microbial drug resistance and implications for research needs in microbial nanotoxicology, Environmental Science: Processes & Impacts, 15, 1, (2013), 93-102 https://doi.org/10.1039/C2EM30692A
  3. Robert Y. Pelgrift, Adam J. Friedman, Nanotechnology as a therapeutic tool to combat microbial resistance, Advanced Drug Delivery Reviews, 65, 13-14, (2013), 1803-1815 https://doi.org/10.1016/j.addr.2013.07.011
  4. Justin T. Seil, Thomas J. Webster, Antimicrobial applications of nanotechnology: methods and literature, International Journal of Nanomedicine, 7, (2012), 2767–2781 https://doi.org/10.2147%2FIJN.S24805
  5. Leena Loomba, Tiziano Scarabelli, Metallic nanoparticles and their medicinal potential. Part I: gold and silver colloids, Therapeutic Delivery, 4, 7, (2013), 859-873 https://doi.org/10.4155/tde.13.55
  6. Carolina Alves Dos Santos, Marcelo Martins Seckler, Avinash P. Ingle, Indarchand Gupta, Stefania Galdiero, Massimiliano Galdiero, Aniket Gade, Mahendra Rai, Silver nanoparticles: therapeutical uses, toxicity, and safety issues, Journal of Pharmaceutical Sciences, 103, 7, (2014), 1931-1944 https://doi.org/10.1002/jps.24001
  7. Debjani Nath, Pratyusha Banerjee, Green nanotechnology–a new hope for medical biology, Environmental Toxicology and Pharmacology, 36, 3, (2013), 997-1014 https://doi.org/10.1016/j.etap.2013.09.002
  8. M. U. Sharief, Senthil Kumar, P. G. Diwakar, TVRS Sharma, Traditional phytotherapy among karens of middle Andaman, Indian Journal of Traditional Knowledge, 4, 4, (2005), 429-436
  9. S. S. Handa, D. D. Rakesh, K. Vasisht, Compendium of Medicinal and Aromatic Plants Volume II - Asia, 2006
  10. Christophe Wiart, Medicinal plants of Asia and the Pacific, CRC press, 2006
  11. Deepa R. Hebbar, M. S. Nalini, Evaluation of phytochemicals, total phenolics and antioxidant activities of Schefflera spp. (Araliaceae) from southern India, Journal of Pharmacognosy and Phytochemistry, 2, 5, (2014), 10-14
  12. R. S. Purwantoro, Andria Agusta, Praptiwi, Aktivitas Antibakteri Ekstrak Daun Schefflera elliptica (Blume) Harms, Prosiding Seminar Nasional HUT Kebun raya Cibodas Ke-159, Bogor, 2012
  13. Maryati Maryati, Ratna Sorayya Fauzia, Triastuti Rahayu, Uji Aktivitas Antibakteri Minyak Atsiri Aun Kemangi (Ocimum Basilicum L.) Terhadap Staphylococcus aureus dan Escherichia coli, Sains dan Teknologi, 8, 1, (2007), 30-38
  14. Nyoman Wendri, Ni Nyoman Rupiasih, Made Sumadiyasa, Biosintesis Nanopartikel Perak Menggunakan Ekstrak Daun Sambiloto: Optimasi Proses Dan Karakterisasi, Jurnal Sains Materi Indonesia, 18, 4, (2017), 162-166 http://dx.doi.org/10.17146/jsmi.2017.18.4.4125
  15. Annisaa Siti Zulaicha, Iwan Syahjoko Saputra, Indah Puspita Sari, M Alvien Ghifari, Yoki Yulizar, Yogi Nopiandi Permana, Sudirman Sudirman, Green Synthesis Nanopartikel Perak (AgNPs) Menggunakan Bioreduktor Alami Ekstrak Daun Ilalang (Imperata cylindrica L), Rafflesia Journal of Natural and Applied Sciences, 1, 1, (2021), 11-19
  16. Dewi Mustika Rahim, Netti Herawati, Hasri Hasri, Sintesis Nanopartikel Perak Menggunakan Bioreduktor Ekstrak Daun Teh Hijau (Camellia Sinensis) dengan Iradiasi Microwave, Chemica: Jurnal Ilmiah Kimia dan Pendidikan Kimia, 22, 2, (2020), 45-55 https://doi.org/10.35580/chemica.v21i1.14835
  17. Tiwi Prasetyaningtyas, Agung Tri Prasetya, Nuni Widiarti, Sintesis Nanopartikel Perak Termodifikasi Kitosan dengan Bioreduktor Ekstrak Daun Kemangi (Ocimum basilicum L.) dan Uji Aktivitasnya sebagai Antibakteri, Indonesian Journal of Chemical Science, 9, 1, (2020), 37-43
  18. Fitriyanti La Tapa, Edi Suryanto, Lidya Irma Momuat, Biosintesis Nanopartikel Perak Menggunakan Ekstrak Empelur Batang Sagu Baruk (Arenga microcarpha) dan Aktivitas Antioksidannya, Chemistry Progress, 9, 1, (2019), 8-13
  19. Asmita J. Gavhane, P. Padmanabhan, Suresh P. Kamble, Suresh N. Jangle, Synthesis of silver nanoparticles using extract of neem leaf and triphala and evaluation of their antimicrobial activities, International Journal of Pharma and Bio Sciences, 3, 3, (2012), 88-100
  20. G. Alagumuthu, R. Kirubha, Green synthesis of silver nanoparticles using Cissus quadrangularis plant extract and their antibacterial activity, International Journal of Nanomaterials and Biostructures, 2, 3, (2012), 30-33
  21. Herbert Chiguvare, Opeoluwa O. Oyedeji, Reuben Matewu, Olukayode Aremu, Idris A. Oyemitan, Adebola O. Oyedeji, Benedicta N. Nkeh-Chungag, Sandile P. Songca, Sneha Mohan, Oluwatobi S. Oluwafemi, Synthesis of silver nanoparticles using Buchu plant extracts and their analgesic properties, Molecules, 21, 6, (2016), 774 https://doi.org/10.3390/molecules21060774
  22. R. Irwan, Muhammad Zakir, Prastawa Budi, Pengaruh Konsentrasi AgNO3 dan Suhu Sintesis terhadap Surface Plasmon Resonance (SPR) Nanopartikel Perak, Indonesian Journal of Chemical Research, 4, 1, (2016), 356-361
  23. Athiah Masykuroh, Nita Abna, Uji Aktivitas Antioksidan Nanopartikel Perak (NPP) Hasil Biosintesis Menggunakan Ekstrak Kulit Buah Jeruk Kunci Citrus microcarpa Bunge, Bioma: Jurnal Biologi Makassar, 7, 2, (2022), 51-64
  24. Fujiana Abd Karim, Robert Tungadi, Nur Ain Thomas, Biosintesis Nanopartikel Perak Ekstrak Etanol 96% Daun Kelor (Moringa oleifera) dan Uji Aktivitasnya Sebagai Antioksidan, Indonesian Journal of Pharmaceutical Education, 2, 1, (2022), 32-41 https://doi.org/10.37311/ijpe.v2i1.11725
  25. Siti Nikmatin, Akhirudin Maddu, Setyo Purwanto, Tieneke Mandang, Aris Purwanto, Analisa struktur mikro pemanfaatan limbah kulit rotan menjadi nanopartikel selulosa sebagai pengganti serat sintetis, Jurnal Biofisika, 7, 1, (2011), 41-49
  26. R. Bhuvaneswari, R. John Xavier, M. Arumugam, Facile synthesis of multifunctional silver nanoparticles using mangrove plant Excoecaria agallocha L. for its antibacterial, antioxidant and cytotoxic effects, Journal of Parasitic Diseases, 41, 1, (2017), 180-187
  27. https://doi.org/10.1007/s12639-016-0773-6
  28. Preetha Devaraj, Prachi Kumari, Chirom Aarti, Arun Renganathan, Synthesis and characterization of silver nanoparticles using cannonball leaves and their cytotoxic activity against MCF-7 cell line, Journal of Nanotechnology, 2013, 598328, (2013), 1-5 https://doi.org/10.1155/2013/598328
  29. D Sudrajat Susanto, R Ruga, Studi kandungan bahan aktif tumbuhan meranti merah (Shorea leprosula Miq) sebagai sumber senyawa antibakteri, Mulawarmnan Scientifie, 11, 2, (2012), 181-190
  30. Kaiyuan Zheng, Magdiel Inggrid Setyawati, David Tai Leong, Jianping Xie, Antimicrobial silver nanomaterials, Coordination Chemistry Reviews, 357, (2018), 1-17 https://doi.org/10.1016/j.ccr.2017.11.019

Last update:

No citation recorded.

Last update: 2024-04-24 20:39:08

No citation recorded.