DOI: https://doi.org/10.14710/jksa.26.10.381-390

Fabrication and Characterization of Chitosan-Polyvinyl Pyrolidone K-30 for Creatinine Transport Membranes

Chemistry Department, Faculty of Sciences and Mathematics, Diponegoro University, Jl. Prof. Soedarto, SH., Tembalang, Semarang, Indonesia

Received: 11 Nov 2023; Revised: 29 Nov 2023; Accepted: 1 Dec 2023; Published: 23 Dec 2023.
Open Access Copyright 2023 Jurnal Kimia Sains dan Aplikasi under http://creativecommons.org/licenses/by-sa/4.0.

Citation Format:
Cover Image
Abstract
The investigation of membrane-based hemodialysis is an interesting study due to its efficacy in eliminating metabolic waste compounds, such as creatinine, from the body. However, not all membrane types exhibit optimal transport capabilities, necessitating modifications. In this study, we conducted modifications on chitosan (CS) membranes by incorporating polyvinyl pyrrolidone K-30 (PVP K-30) and assessing their physicochemical characteristics. The modified membrane underwent characterization and subsequent evaluation of its transport capabilities. The primary objective of this research is to design a membrane composed of chitosan and PVP K-30 with enhanced creatinine transport capabilities. The study commenced with the fabrication of CS membranes combined with CS-PVP, involving six variations of CS and PVP K-30 with volume ratios of 5:0, 4:1, 3:2, 1:1, 2:3, and 4:1. The resulting solution was then printed into a flat sheet membrane. All completed membranes underwent comprehensive characterization, including tests for functional groups using Fourier Transform Infrared (FTIR), membrane weight and thickness, porosity, water absorption, swelling, hydrophilicity, pH resistance, and biodegradation. In the final phase, the membrane was utilized in the creatinine transport process. FTIR analysis of the CS-PVP K-30 membrane revealed O-H and N-H group spectra at wave numbers 3363.06 cm-1 and 1587.17 cm-1, indicating hydrogen bonding between the two polymers. Characterization tests demonstrated that the CS-PVP membrane exhibited increased porosity, water absorption, swelling, and hydrophilicity. In the creatinine transport test, the CS-PVP membrane demonstrated enhanced creatinine transport ability compared to the CS membrane. The highest clearance value for creatinine was observed in the CS-PVP5 membrane, with an increase in the amount of PVP K-30 correlating with an elevated creatinine clearance value. The creatinine clearance values for the CS membrane, CS-PVP1, CS-PVP2, CS-PVP3, CS-PVP4, and CS-PVP5 were 0.30, 0.36, 0.37, 0.39, 0.42, and 0.46 mg/dL, respectively.
Fulltext View|Download
Keywords: Hydrophilicity; Chitosan; Creatinine; Membrane; PVP; Transport

Article Metrics:

Article Info
Section: Research Articles
Language : EN
Recent articles
Synthesis and Characterization of Fe-doped Hydroxyapatite/ZnO Nanocomposites Using the Coprecipitation Method from Processed Limestone Fabrication and Characterization of Chitosan-Polyvinyl Pyrolidone K-30 for Creatinine Transport Membranes Rosella Petal Extract (Hibiscus sabdariffa Linn.) as a Reducing Agent in Silver Nanoparticle Synthesis and Its Antibacterial Activity More recent articles
Most cited articles
Sintesis Silika Kristalin Menggunakan Surfaktan Cetiltrimetilamonium Bromida (CTAB) dan Trimetilamonium Klorida (TMACl) sebagai Pencetak Pori Utilization of Rice Husk Cellulose as a Magnetic Nanoparticle Biocomposite Fiber Source for the Absorption of Manganese (Mn2+) Ions in Peat Water Pemanfaatan Karbon Aktif Serbuk Gergaji Kayu Jati untuk Menurunkan Chemical Oxygen Demand (COD) Limbah Cair Industri Tekstil Sintesis Bahan Hibrida Amino-Silika dari Abu Sekam Padi Melalui Proses Sol-Gel Molecular Docking of Interaction between E-Cadherin Protein and Conformational Structure of Cyclic Peptide ADTC3 (Ac-CADTPC-NH2) Simulated on 20 ns More cited articles
  1. Retno Ariadi Lusiana, Ginanjar Argo Pambudi, Fitra Nilla Sari, Didik Setiyo Widodo, Khabibi Khabibi, Sri Isdadiyanto, Grafting of Heparin on Blend Membrane of Citric Acid Cross-linked Chitosan/Polyethylene Glycol-Poly Vinyl Alcohol (PVA-PEG), Indonesian Journal of Chemistry, 19, 1, (2019), 151-159 https://doi.org/10.22146/ijc.30861
  2. Noresah Said, Woei Jye Lau, Yeek-Chia Ho, Soo Kun Lim, Muhammad Nidzhom Zainol Abidin, Ahmad Fauzi Ismail, A Review of Commercial Developments and Recent Laboratory Research of Dialyzers and Membranes for Hemodialysis Application, Membranes, 11, 10, (2021), 767 https://doi.org/10.3390/membranes11100767
  3. Paul L. Kimmel, Depression in patients with chronic renal disease: What we know and what we need to know, Journal of Psychosomatic Research, 53, 4, (2002), 951-956 https://doi.org/10.1016/S0022-3999(02)00310-0
  4. Xufeng Yu, Lingdi Shen, Yadong Zhu, Xiong Li, Yin Yang, Xuefen Wang, Meifang Zhu, Benjamin S. Hsiao, High performance thin-film nanofibrous composite hemodialysis membranes with efficient middle-molecule uremic toxin removal, Journal of Membrane Science, 523, (2017), 173-184 https://doi.org/10.1016/j.memsci.2016.09.057
  5. Arash Mollahosseini, Amira Abdelrasoul, Novel insights in hemodialysis: Most recent theories on membrane hemocompatibility improvement, Biomedical Engineering Advances, 3, (2022), 100034 https://doi.org/10.1016/j.bea.2022.100034
  6. Shamo Zokhrab Tapdigov, The bonding nature of the chemical interaction between trypsin and chitosan based carriers in immobilization process depend on entrapped method: A review, International Journal of Biological Macromolecules, 183, (2021), 1676-1696 https://doi.org/10.1016/j.ijbiomac.2021.05.059
  7. S. Islam, M. A. Rahman Bhuiyan, M. N. Islam, Chitin and Chitosan: Structure, Properties and Applications in Biomedical Engineering, Journal of Polymers and the Environment, 25, (2017), 854-866 https://doi.org/10.1007/s10924-016-0865-5
  8. O. S. Serbanescu, S. I. Voicu, V. K. Thakur, Polysulfone functionalized membranes: Properties and challenges, Materials Today Chemistry, 17, (2020), 100302 https://doi.org/10.1016/j.mtchem.2020.100302
  9. Meng Zhang, Guohui Wang, Dong Wang, Yuqi Zheng, Yanxin Li, Wenqiao Meng, Xin Zhang, Feifan Du, Shaoxiang Lee, Ag@MOF-loaded chitosan nanoparticle and polyvinyl alcohol/sodium alginate/chitosan bilayer dressing for wound healing applications, International Journal of Biological Macromolecules, 175, (2021), 481-494 https://doi.org/10.1016/j.ijbiomac.2021.02.045
  10. Shijie Kou, Linda M. Peters, Michael R. Mucalo, Chitosan: A review of sources and preparation methods, International Journal of Biological Macromolecules, 169, (2021), 85-94 https://doi.org/10.1016/j.ijbiomac.2020.12.005
  11. Saiful, Lidiya Mardiyana, Rahmi, Khairi Suhud, Yanuardi Raharjo, Chitosan-starch cross-linked citric acid as adsorptive hemodialysis membrane, Materials Today: Proceedings, 65, (2022), 2986-2991 https://doi.org/10.1016/j.matpr.2022.03.575
  12. R. Poonguzhali, S. Khaleel Basha, V. Sugantha Kumari, Fabrication of asymmetric nanostarch reinforced Chitosan/PVP membrane and its evaluation as an antibacterial patch for in vivo wound healing application, International Journal of Biological Macromolecules, 114, (2018), 204-213 https://doi.org/10.1016/j.ijbiomac.2018.03.092
  13. Nasrul Arahman, Sri Mulyati, Afrillia Fahrina, Syawaliah Muchtar, Mukramah Yusuf, Ryosuke Takagi, Hideto Matsuyama, Nik Abdul Hadi Nordin, Muhammad Roil Bilad, Improving Water Permeability of Hydrophilic PVDF Membrane Prepared via Blending with Organic and Inorganic Additives for Humic Acid Separation, Molecules, 24, 22, (2019), 4099 https://doi.org/10.3390/molecules24224099
  14. Muhammad Irfan, Masooma Irfan, Syed Mazhar Shah, Nadeem Baig, Tawfik A. Saleh, Mahmood Ahmed, Gul Naz, Naeem Akhtar, Nawshad Muhammad, Ani Idris, Hemodialysis performance and anticoagulant activities of PVP-k25 and carboxylic-multiwall nanotube composite blended Polyethersulfone membrane, Materials Science and Engineering: C, 103, (2019), 109769 https://doi.org/10.1016/j.msec.2019.109769
  15. K. Lewandowska, Surface properties of chitosan composites with poly(N-vinylpyrrolidone) and montmorillonite, Polymer Science, Series A, 59, (2017), 215-222 https://doi.org/10.1134/S0965545X17020043
  16. R. Poonguzhali, S. Khaleel Basha, V. Sugantha Kumari, Synthesis and characterization of chitosan/poly (vinylpyrrolidone) biocomposite for biomedical application, Polymer Bulletin, 74, (2017), 2185-2201 https://doi.org/10.1007/s00289-016-1831-z
  17. R. H. Sizílio, J. G. Galvão, G. G. G. Trindade, L. T. S. Pina, L. N. Andrade, J. K. M. C. Gonsalves, A. A. M. Lira, M. V. Chaud, T. F. R. Alves, M. L. P. M. Arguelho, R. S. Nunes, Chitosan/pvp-based mucoadhesive membranes as a promising delivery system of betamethasone-17-valerate for aphthous stomatitis, Carbohydrate Polymers, 190, (2018), 339-345 https://doi.org/10.1016/j.carbpol.2018.02.079
  18. Hossein Rahmani, Seyed Heydar Mahmoudi Najafi, Alireza Ashori, Marzieh Arab Fashapoyeh, Farzaneh Aziz Mohseni, Sara Torkaman, Preparation of chitosan-based composites with urethane cross linkage and evaluation of their properties for using as wound healing dressing, Carbohydrate Polymers, 230, (2020), 115606 https://doi.org/10.1016/j.carbpol.2019.115606
  19. Qiu Gen Zhang, Wen Wei Hu, Ai Mei Zhu, Qing Lin Liu, UV-crosslinked chitosan/polyvinylpyrrolidone blended membranes for pervaporation, RSC Advances, 3, (2013), 1855-1861 https://doi.org/10.1039/C2RA21827E
  20. Hasan Muhtar, Adi Darmawan, Fabrication of negatively charged nanofiltration membrane of modified polystyrene intercalated graphene oxide for pervaporation desalination, Chemical Engineering Journal, 475, (2023), 146095 https://doi.org/10.1016/j.cej.2023.146095
  21. Retno Ariadi Lusiana, Vivi Dia Ahmad Sangkota, Sri Juari Santosa, Chitosan succinate/PVA-PEG Membrane: Preparation, Characterization and Permeation Ability Test on Creatinine, Jurnal Kimia Sains dan Aplikasi, 21, 2, (2018), 80-84 https://doi.org/10.14710/jksa.21.2.80-84
  22. Retno Ariadi Lusiana, Dian Tri Pratama, Hasan Muhtar, Facile modification of polyvinylidene fluoride membrane for enhancing dialysis performance: sulfonation, adding polyethylene glycol and tuning coagulation bath temperature, Journal of Macromolecular Science, Part A, (2023), 1-12 https://doi.org/10.1080/10601325.2023.2287044
  23. Shih-Hsien Wang, Peter R. Griffiths, Resolution enhancement of diffuse reflectance i.r. spectra of coals by Fourier self-deconvolution: 1. C-H stretching and bending modes, Fuel, 64, 2, (1985), 229-236 https://doi.org/10.1016/0016-2361(85)90223-6
  24. Mohammed S. Al Mogbel, Mohamed T. Elabbasy, Rasha S. Mohamed, A. E. Ghoniem, M. F. H. Abd El-Kader, A. A. Menazea, Improvement in antibacterial activity of Poly Vinyl Pyrrolidone/Chitosan incorporated by graphene oxide NPs via laser ablation, Journal of Polymer Research, 28, (2021), 474 https://doi.org/10.1007/s10965-021-02838-x
  25. Qianzhu Li, Dongzhi Yang, Guiping Ma, Qiang Xu, Xiangmei Chen, Fengmin Lu, Jun Nie, Synthesis and characterization of chitosan-based hydrogels, International Journal of Biological Macromolecules, 44, 2, (2009), 121-127 https://doi.org/10.1016/j.ijbiomac.2008.11.001
  26. Saima Sultana, Nafees Ahmad, Syed M. Faisal, M. Owais, Suhail Sabir, Synthesis, characterisation and potential applications of polyaniline/chitosan-Ag-nano-biocomposite, IET Nanobiotechnology, 11, 7, (2017), 835-842 https://doi.org/10.1049/iet-nbt.2016.0215
  27. Mohammed Eddya, Bouazza Tbib, Khalil El-Hami, A comparison of chitosan properties after extraction from shrimp shells by diluted and concentrated acids, Heliyon, 6, 2, (2020), E03486 https://doi.org/10.1016/j.heliyon.2020.e03486
  28. Ritesh Kumar, Indrani Mishra, Gulshan Kumar, Synthesis and Evaluation of Mechanical Property of Chitosan/PVP Blend Through Nanoindentation-A Nanoscale Study, Journal of Polymers and the Environment, 29, (2021), 3770-3778 https://doi.org/10.1007/s10924-021-02143-0
  29. Adi Darmawan, Anjalya Figo Nur Sabarina, Damar Nurwahyu Bima, Hasan Muhtar, Christina Wahyu Kartikowati, Teguh Endah Saraswati, New design of graphene oxide on macroporous nylon assisted polyvinyl alcohol with Zn (II) cross-linker for pervaporation desalination, Chemical Engineering Research and Design, 195, (2023), 54-64 https://doi.org/10.1016/j.cherd.2023.05.029
  30. B. Chakrabarty, A. K. Ghoshal, M. K. Purkait, Preparation, characterization and performance studies of polysulfone membranes using PVP as an additive, Journal of Membrane Science, 315, 1, (2008), 36-47 https://doi.org/10.1016/j.memsci.2008.02.027
  31. M. O. Mavukkandy, M. R. Bilad, J. Kujawa, S. Al-Gharabli, H. A. Arafat, On the effect of fumed silica particles on the structure, properties and application of PVDF membranes, Separation and Purification Technology, 187, (2017), 365-373 https://doi.org/10.1016/j.seppur.2017.06.077
  32. David Aili, Mikkel Rykær Kraglund, Joe Tavacoli, Christodoulos Chatzichristodoulou, Jens Oluf Jensen, Polysulfone-polyvinylpyrrolidone blend membranes as electrolytes in alkaline water electrolysis, Journal of Membrane Science, 598, (2020), 117674 https://doi.org/10.1016/j.memsci.2019.117674
  33. Xiaorui Ren, Huanhuan Li, Ke Liu, Hongyi Lu, Jingshuai Yang, Ronghuan He, Preparation and Investigation of Reinforced PVP Blend Membranes for High Temperature Polymer Electrolyte Membranes, Fibers and Polymers, 19, 12, (2018), 2449-2457 https://doi.org/10.1007/s12221-018-8361-2
  34. Caiqin Qin, Huirong Li, Qi Xiao, Yi Liu, Juncheng Zhu, Yumin Du, Water-solubility of chitosan and its antimicrobial activity, Carbohydrate Polymers, 63, 3, (2006), 367-374 https://doi.org/10.1016/j.carbpol.2005.09.023
  35. Yang Liu, Chuang Lang, Yaping Ding, Siyu Sun, Guangwei Sun, Chitosan with enhanced deprotonation for accelerated thermosensitive gelation with β-glycerophosphate, European Polymer Journal, 196, (2023), 112229 https://doi.org/10.1016/j.eurpolymj.2023.112229
  36. Jen-Taut Yeh, Chin-Lai Chen, K. S. Huang, Y. H. Nien, J. L. Chen, P. Z. Huang, Synthesis, characterization, and application of PVP/chitosan blended polymers, Journal of Applied Polymer Science, 101, 2, (2006), 885-891 https://doi.org/10.1002/app.23517
  37. Cristiana M. P. Yoshida, Enio Nazaré Oliveira Junior, Telma Teixeira Franco, Chitosan tailor-made films: the effects of additives on barrier and mechanical properties, Packaging Technology and Science, 22, 3, (2009), 161-170 https://doi.org/10.1002/pts.839
  38. Mohtada Sadrzadeh, Subir Bhattacharjee, Rational design of phase inversion membranes by tailoring thermodynamics and kinetics of casting solution using polymer additives, Journal of Membrane Science, 441, (2013), 31-44 https://doi.org/10.1016/j.memsci.2013.04.009

Last update:

No citation recorded.

Last update: 2024-11-24 19:22:25

No citation recorded.