DOI: https://doi.org/10.14710/jai.v0i0.46154

Sindroma Kardiorenal

Departemen Anestesiologi dan Terapi Intensif, Fakultas Kedokteran, Universitas Indonesia, Jakarta, Indonesia

Published: 30 Nov 2022.
Open Access Copyright 2021 JAI (Jurnal Anestesiologi Indonesia)

Citation Format:
Abstract

Cardiorenal syndrome (CRS) atau sindroma kardiorenal merupakan suatu kondisi dimana terjadi penyakit ginjal dan penyakit jantung secara bersamaan yang progresifitasnya terjadi dengan cepat. Pada kasus dimana penyakit jantung merupakan penyakit primer, yang terjadi adalah gangguan dinamika kardioavaskular, aktivasi neurohormonal dan faktor inflamasi yang terlibat dalam awal-mulanya perburukan fungsi ginjal dan penyakit ginjal yang progresif.

Sepsis adalah “respons sistemik terhadap infeksi yang telah terdokumenetasi atau masih dicurigai dan terjadi disfungsi satu organ”; terdiri dari hipotermia/hipertermia, takikardia, takipnea, infeksi, dan disfungsi organ akhir akibat hipoperfusi. Sepsis yang lebih modern didasari konsep SIRS, sebuah istilah yang mendeskripsikan kompleks imun sebagai respons infeksi dan digunakan untuk menggambarkan ciri klinis yang berkaitan dengan respons tersebut. Penggunaan klinis SIRS menggambarkan kekacauan laju nafas, frekuensi denyut jantung, temperature, dan jumlah leukosit. Jika ada 2 dari 4 kriteria di bawah ini, SIRS bisa ditegakkan: nafas > 20 kali per menit atau PaCo2 <32 mmHg, frekuensi nadi >90 kali per menit, suhu >38o C atau <36o C, dan leukosit >12,000/mm3 atau <4,000/mm3.

CRS sepsis adalah disfungsi renal dan kardiak yang terjadi bersamaan dalam sebuah kondisi sistemik primer yang mempengaruhi kedua organ. “Tuntutan iskemik” jantung didasarkan pada alasan meningkatnya kebutuhan oksigen berkaitan dengan respons sepsis (misalnya takikardia, peningkatan curah jantung) yang mengarah kepada cedera iskemik. Disfungsi renal dapat dilihat selama sepsis berat dan merupakan bagian dari gambaran klinis syok septik dan kegagalan multi organ.

Fulltext View|Download
Keywords: disfungsi renal; sepsis; sindroma kardiorenal; SIRS; syok septik

Article Metrics:

Article Info
Section: Literature Reviews
Language : ID
Recent articles
Perbandingan Rasio Lingkar Leher Terhadap Jarak Tiromental dengan Skor Mallampati dan Jarak Tiromental Sebagai Prediktor Kesulitan Visualisasi Laring pada Pasien Bedah Elektif Di RSUPN Cipto Mangunkusumo Pengaruh Jenis Kelamin, Usia, dan Data Antropometrik terhadap Landmark Blok Popliteal Pengaruh Melatonin terhadap Kadar Leukosit Tikus Wistar Model Luka Bakar dalam Kurun Waktu Dua Hari Seorang Wanita 19 tahun G1P0A0 Hamil 31 Minggu dengan Eklamsia Tata Laksana Pasien Kritis pada Sumber Daya Terbatas Seksio Sesarea pada Wanita G2P1A0 Hamil Aterm dengan Confirmed COVID-19 Disertai Diabetes Mellitus Dalam Terapi Insulin dan HIV Positif Enhanced Recovery After Cesarean Surgery (ERACS): Analisis Berbasis Bukti Sindroma Kardiorenal More recent articles
Most cited articles
Patofisiologi Penyakit Jantung Koroner Midazolam Intravena Dosis Rendah Tidak Mempengaruhi Nitric Oxide Intraperitoneal Mencit Balb/C Yang Terpapar Lipopolisakarida More cited articles
  1. Berbari, A.E. Links between Chronic Kidney Disease & Cardiovascular Disease:A Bidirectional Relationship. Cardiorenal Syndrome 2010;3-12
  2. Schrier RW. Cardiorenal versus renocardiac syndrome: is there a difference? Nat Clin Pract Nephrol 2007; 3:637
  3. C. Ronco, “Cardiorenal syndromes: definition and classifica¬tion,” Contributions to Nephrology, vol. 164, pp. 33–38, 2010
  4. Haldeman GA: Hospitalization of patients with heart failure: National Hospital Discharge Survey, 1985 to 1995. Am Heart J 1999;137:352–360
  5. Fonarow GC, Gattis Stough W, Abraham WT, et al: Characteristics, treatments and outcomes of patients with preserved systolic function hospitalized for heart failure. J Am Coll Cardiol 2007;50:768–777
  6. Jose P, Skali H, Anavekar N, et al: Increase in creatinine and cardiovascular risk in patients with systolic dysfunction after myocardial infarction. J Am Soc Nephrol 2006;17:2886– 2891
  7. Haase M, Mueller C, Damman K, Murray P: Cardiorenal Syndrome Type 1 in Acute Decompensated Heart Failure: Workgroup Statements from the Eleventh Consensus Conference of the Acute Dialysis Quality Initiative (ADQI), 2013
  8. Hillege HL, Nitsch D, Pfeffer MA, et al: Renal function as a predictor of outcome in a broad spectrum of patients with heart failure. Circulation 2006;113:671–678
  9. Liang KV, Williams AW, Greene EL, Redfield MM: Acute decompensated heart failure and the cardio-renal syndrome. Crit Care Med 2008;36(suppl):S75–S88
  10. Bone RC, Balk RA, Cerra FB, Dellinger RP, Fein AM, Knaus WA, et al. Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. The ACCP/SCCM Consensus Conference Committee. American College of Chest Physicians/Society of Critical Care Medicine. Chest. 1992;101(6):1644-55
  11. American College of Chest Physicians/Society of Critical Care Medicine Consensus Conference: definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. Crit Care Med. 1992;20(6):864-74
  12. Geroulanos S, Douka ET. Historical Perspective of the word “sepsis”. Intensive Care Med. 2006;32(12):2077
  13. Liang KV, Williams AW, Greene EL, Redfield MM: Acute decompensated heart failure and the cardio-renal syndrome. Crit Care Med 2008;36(suppl):S75–S88
  14. Hong T, Chang C, Ko W,Lin C, Liu H, Chw L, et al. biomarkers of early sepsis may be correlated with outcome. J Transl Med. 2014;12:146
  15. Simon L, Gauvin F, Amre D, Saint Louis P, Lacroix J. Serum procalcitonin and C-reactive protein levels as markers of bacterial infection: a systematic review and meta-analysis. Clin Infect Dis. 2004;39:206-17
  16. Sunden-Cullberg J, Norrby-Teglund A, Rouhiainen A, Rauvala H, Herman G, Tracey K, et al. Persistent elevation of high mobility group box-1 protein (HMGB-1) in patients with severe sepsis and septic shock. Crit Care Med. 2005;33;564-73
  17. Narvaez-Rivera R, Rendon A, Salinas-Carmona M. Rossa-Taraco A. Soluble RAGE as a severity marker in community acquired pneumonia associated sepsis. BMC Infect Dis. 2012;12;15
  18. Jeong S, Song Y, Kim C, Kim H, Ku N, Han S, et al. Measurement of plasma sTREM-1 in patients with severe sepsis receiving early goal directed therapy and evaluation of its usefulness. Shock. 2012;37:574-8
  19. Uchino S, Bellomo R, Goldsmith D, Bates S: An assessment of the RIFLE criteria for ARF in hospitalized patients. Crit Care Med 2006; 34:1913–1917
  20. Jose P, Skali H, Anavekar N, et al: Increase in creatinine and cardiovascular risk in patients with systolic dysfunction after myocardial infarction. J Am Soc Nephrol 2006;17:2886– 2891
  21. Sarnak MJ, Levey AS, Schoolwerth AC, et al: Kidney disease as a risk factor for devel¬opment of cardiovascular disease: a state¬ment from the American Heart Association Councils on Kidney in Cardiovascular Disease, High Blood Pressure Research, Clinical Cardiology, and Epidemiology and Prevention. Hypertension 2003;42:1050– 1065
  22. Kumar A, Paladugu B, Mensing J, Kumar A, Parrillo JE: Nitric oxide-dependent and inde¬pendent mechanisms are involved in TNF-alpha induced depression of cardiac myocyte contractility. Am J Physiol Regul Integr Comp Physiol 2007;292:R1900–R1906
  23. Gomez H, Ince C, De Backer D, Pickkers P, Payen D, Hotchkiss J, et al. A unified theory of sepsis-induced acute kidney injury:inflammation, microcirculatory dysfunction, bioenergetics, and the tubular cell adaptation to injury. Shock. 2014;41(1):3-11
  24. Lorente L, Iceta R, Martin MM, Lopez-Gallardo E, Sole-Violan J, B;anquer J, et al. Survival and mithocondrial function in septic patients according to mithochondrial DNA haplogroup. Crit Care, 2012;16(1):R10
  25. Hong T, Chang C, Ko W,Lin C, Liu H, Chw L, et al. biomarkers of early sepsis may be correlated with outcome. J Transl Med. 2014;12:146
  26. Pierrakos C, Vincent J. Sepsis biomarkers: a review. Crit Care. 2010;14:R15
  27. Howard PA, Dunn MI: Aggressive diuresis for severe heart failure in the elderly. Chest 2001;119:807–610
  28. Butler J, Forman DE, Abraham WT, et al: Relationship between heart failure treatment and development of worsening renal func¬tion among hospitalized patients. Am Heart Journal 2004;147:331–339
  29. Palazzuoli A, Silverberg DS, Iovine F, et al: Effects of beta-erythropoietin treatment of left ventricular remodelling, systolic func¬tion, and B-type natriuretic peptide levels in patients with the cardio-renal anemia syn¬drome. Am Heart J 2007;154:e9–e15
  30. John J, Woodward DB, Wang Y, Yan SB, Fisher D, Kinasewitz GT, et al. Troponin-I as a prognosticator of mortality in severe sepsis patients. J Crit Care. 2010;25(2):270-5

Last update:

No citation recorded.

Last update: 2024-11-03 21:50:54

No citation recorded.