DOI: https://doi.org/10.14710/jksa.23.12.424-431

Synthesis of the BEAC4ND4 Ionophore from p-t-Butylcalix[4]arene Carboxylic Acid

1Department of Chemistry, Halu Oleo University, Indonesia

2Department of Chemistry Education, Faculty of Teacher Training and Education, Halu Oleo University, Indonesia

3Department of Chemistry, Faculty of Mathematics and Natural Sciences, Hasanuddin University, Indonesia

4 Study Program of Tadris Biology, Faculty of Tarbiyah and Teacher Training, Institut Agama Islam Negeri IAIN Kendari, Indonesia

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Received: 27 May 2020; Revised: 9 Nov 2020; Accepted: 29 Dec 2020; Published: 31 Jan 2021.
Open Access Copyright 2020 Jurnal Kimia Sains dan Aplikasi under http://creativecommons.org/licenses/by-sa/4.0.

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Abstract
The BEAC4ND4 ionophore has been successfully synthesized from p-t-butylcalix[4]arene carboxylic acid. The BEAC4ND4 ionophore was obtained in two steps of the synthesis reaction. The first step is the chlorination reaction of p-t-butylcalix[4]arene carboxylic acid with thionyl chloride in dry benzene solvent. The chlorination reaction product is p-t-butylcalix[4]arene acyl chloride in the form of the light brown viscous liquid with a yield of 78.25% and TLC (SiO2, CH3OH: CH2Cl2 = 1: 1 v/v, Rf = 0.65). The second step is the amidation reaction of ethyl 2-aminoacetate with p-t-butylcalix[4]arene acyl chloride in dry tetrahydrofuran solvent. The product of the amidation reaction is p-t-butylcalix[4]arene ethylesteramide or the BEAC4ND4 ionophore in the form of a white solid with the yield of 75.22%, a melting point of 314-316°C, and TLC (SiO2, CH3OH: CH2Cl2 = 1: 1 v/v, Rf = 0.75).
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Keywords: BEAC4ND4 ionophore; chlorination; amidation; calix[4]arene; carboxylic acid
Funding: Halu Oleo University

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Section: Research Articles
Language : EN
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Last update: 2024-11-19 14:50:56

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