DOI: https://doi.org/10.14710/jksa.27.4.189-196

Optimization of Chitosan-Carboxymethyl Chitosan Membrane Modification with PVA to Increase Creatinine and Urea Permeation Efficiency

Chemistry Department, Faculty of Sciences and Mathematics, Diponegoro University, Jl. Prof. Soedarto, SH., Tembalang, Semarang, Indonesia

Received: 25 Mar 2024; Revised: 20 Apr 2024; Accepted: 23 Apr 2024; Published: 30 Apr 2024.
Open Access Copyright 2024 Jurnal Kimia Sains dan Aplikasi under http://creativecommons.org/licenses/by-sa/4.0.

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Abstract
Polyvinyl alcohol (PVA) modified chitosan-carboxymethyl chitosan (CMC) membrane has been successfully fabricated and used as a dialysis membrane. This research aims to examine the manufacturing process, characterization, and dialysis performance of CMC and PVA-modified chitosan membranes. The membrane used the phase inversion method in acetic acid solvent with 5 CS:CMC: PVA dope compositions. Based on FTIR data, the modification process did not produce new spectra. Furthermore, the interaction produces a membrane with higher physical characteristics in terms of porosity, swelling, water uptake, hydrophilicity, and pH resistance values, which increase by 1.5–115%. Meanwhile, chitosan modification makes the membrane structure different from the original, requiring a longer degradation time. The modification also increased the permeation ability of urea by 17–65% and creatinine permeation by 20–62%. Membranes have the ability to be used more than once.
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Keywords: Membrane; Chitosan; Carboxymethyl chitosan; Polyvinyl alcohol; Permeation
Funding: Faculty of Sciences and Mathematics, Diponegoro University under contract 40.E2/UN7.F8/PP/II/2023

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Section: Research Articles
Language : EN
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